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Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study

Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study


Title: Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study
Author: Teitsdóttir, Unnur Diljá   orcid.org/0000-0003-2723-2242
Arnardóttir, Erna Sif
Björnsdóttir, Erla
Gíslason, Þórarinn
Petersen, Petur Henry   orcid.org/0000-0001-6622-3002
Date: 2018-10-11
Language: English
Scope: 1101-1109
University/Institute: Háskóli Íslands
University of Iceland
Háskólinn í Reykjavík
Reykjavik University
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Lífvísindasetur (HÍ)
Biomedical Center (UI)
Series: Sleep and Breathing;22(4)
ISSN: 1520-9512
1522-1709 (eISSN)
DOI: 10.1007/s11325-018-1731-6
Subject: Obstructive sleep apnea; Positive airway pressure; Obesity; Chitinase-3-like protein 1; Chitotriosidase; Kæfisvefn; Offita
URI: https://hdl.handle.net/20.500.11815/1270

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Citation:

Teitsdottir, U. D., Arnardottir, E. S., Bjornsdottir, E., Gislason, T., & Petersen, P. H. (2018). Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study. Sleep and Breathing, 22(4), 1101-1109. doi:10.1007/s11325-018-1731-6

Abstract:

Purpose The inflammatory markers chitinase-3-like protein 1 (CHI3L1) and chitotriosidase (CHIT1) have both been associated with cardiovascular complications. The aim of this preliminary observational study was to assess the roles and interaction of obstructive sleep apnea (OSA) severity and body mass index (BMI) with plasma CHI3L1 levels and CHIT1 activity in patients with moderate to severe OSA. The second aim was to assess the roles and interaction of positive airway pressure (PAP) treatment and BMI on the expression of the same proteins. Methods The study included 97 OSA patients with an apnea–hypopnea index (AHI) ≥ 15 and full usage of PAP treatment after 4 months. Plasma CHI3L1 levels and CHIT1 activity were measured before and after treatment. Results Multiple linear regression analysis demonstrated an independent association of BMI on CHI3L1 levels (p < 0.05) but not on CHIT1 activity. The OSA severity markers (AHI and oxygen desaturation index) did not independently or in interaction with BMI levels associate with CHI3L1 levels or with CHIT1 activity (p > 0.05). A two-way repeated measures ANOVA revealed a significant interaction between PAP treatment effect (before vs. after) and BMI groups (< 35 kg/m2 vs. ≥ 35 kg/m2 ) on CHI3L1 levels (p = 0.03) but not on CHIT1 activity (p = 0.98). Conclusions Obesity independently associated with CHI3L1 levels. Association between OSA severity and CHI3L1 levels or CHIT1 activity (independent of or dependent on obesity level) could not be confirmed. Howe

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