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Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds

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dc.contributor Landbúnaðarháskóli Íslands
dc.contributor Agricultural University of Iceland
dc.contributor.author Xu, Song-Song
dc.contributor.author Gao, Lei
dc.contributor.author Xie, Xing-Long
dc.contributor.author Ren, Yan-Ling
dc.contributor.author Shen, Zhi-Qiang
dc.contributor.author Wang, Feng
dc.contributor.author Shen, Min
dc.contributor.author Eythorsdottir, Emma
dc.contributor.author Hallsson, Jon
dc.contributor.author Kiseleva, Tatyana
dc.contributor.author Kantanen, Juha
dc.contributor.author Li, Meng-Hua
dc.date.accessioned 2019-09-24T11:13:48Z
dc.date.available 2019-09-24T11:13:48Z
dc.date.issued 2018-04-10
dc.identifier.citation Xu, S. S., Gao, L., Xie, X. L., Ren, Y. L., Shen, Z. Q., Wang, F., ... & Kantanen, J. (2018). Genome-wide association analyses highlight the potential for different genetic mechanisms for litter size among sheep breeds. Frontiers in genetics, 9, 118.
dc.identifier.issn 1664-8021
dc.identifier.uri https://hdl.handle.net/20.500.11815/1260
dc.description Author Contributions: M-HL conceived and designed the project. FW, Z-QS, Y-LR, MS, EE, JH, JK, and TK collected the samples. X-LX extracted the DNA. JK provided help in Beadchip genotyping. S-SX and LG analyzed the data. S-SX wrote the paper with contributions from M-HL. All authors reviewed and approved the final manuscript.
dc.description.abstract Reproduction is an important trait in sheep breeding as well as in other livestock. However, despite its importance the genetic mechanisms of litter size in domestic sheep (Ovis aries) are still poorly understood. To explore genetic mechanisms underlying the variation in litter size, we conducted multiple independent genome-wide association studies in five sheep breeds of high prolificacy (Wadi, Hu, Icelandic, Finnsheep, and Romanov) and one low prolificacy (Texel) using the Ovine Infinium HD BeadChip, respectively. We identified different sets of candidate genes associated with litter size in different breeds: BMPR1B, FBN1, and MMP2 in Wadi; GRIA2, SMAD1, and CTNNB1 in Hu; NCOA1 in Icelandic; INHBB, NF1, FLT1, PTGS2, and PLCB3 in Finnsheep; ESR2 in Romanov and ESR1, GHR, ETS1, MMP15, FLI1, and SPP1 in Texel. Further annotation of genes and bioinformatics analyses revealed that different biological pathways could be involved in the variation in litter size of females: hormone secretion (FSH and LH) in Wadi and Hu, placenta and embryonic lethality in Icelandic, folliculogenesis and LH signaling in Finnsheep, ovulation and preovulatory follicle maturation in Romanov, and estrogen and follicular growth in Texel. Taken together, our results provide new insights into the genetic mechanisms underlying the prolificacy trait in sheep and other mammals, suggesting targets for selection where the aim is to increase prolificacy in breeding projects.
dc.description.sponsorship This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 91731309 and 31661143014), the Taishan Scholars Program of Shandong Province (No. ts201511085), the National Transgenic Breeding Project of China (2014ZX0800952B), the Academy of Finland (Grant No. 250633), and the Climate Genomics for Farm Animal Adaptation (ClimGen) Project.
dc.format.extent 118
dc.language.iso en
dc.publisher Frontiers Media SA
dc.relation.ispartofseries Frontiers in Genetics;9
dc.rights info:eu-repo/semantics/openAccess
dc.subject Sheep
dc.subject Genome-wide association studies
dc.subject Prolificacy
dc.subject Sauðfé
dc.subject Erfðarannsóknir
dc.title Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds
dc.type info:eu-repo/semantics/article
dcterms.license Frontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified.
dc.description.version Peer Reviewed
dc.identifier.journal Frontiers in Genetics
dc.identifier.doi 10.3389/fgene.2018.00118
dc.relation.url http://journal.frontiersin.org/article/10.3389/fgene.2018.00118/full
dc.contributor.department Auðlinda- og umhverfisdeild (LBHÍ)
dc.contributor.department Faculty of Natural Resources and Environmental Sciences (AUI)

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