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Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland


Title: Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland
Author: Quirk, Sigríður Júlía   orcid.org/0000-0002-8254-9720
Haraldsson, Gunnsteinn   orcid.org/0000-0002-9897-0384
Erlendsdóttir, Helga
Hjálmarsdóttir, Martha Ásdís   orcid.org/0000-0002-9764-9943
van Tonder, Andries J.
Hrafnkelsson, Birgir   orcid.org/0000-0003-1864-9652
Sigurdsson, Samuel   orcid.org/0000-0001-7517-6973
Bentley, Stephen D.
Haraldsson, Ásgeir   orcid.org/0000-0001-5364-7877
Brueggemann, Angela B.
... 1 more authors Show all authors
Date: 2018-09-26
Language: English
University/Institute: Háskóli Íslands
University of Iceland
School: Heilbrigðisvísindasvið (HÍ)
School of Health Sciences (UI)
Verkfræði- og náttúruvísindasvið (HÍ)
School of Engineering and Natural Sciences (UI)
Department: Læknadeild (HÍ)
Faculty of Medicine (UI)
Lífvísindasetur (HÍ)
Biomedical Center (UI)
Raunvísindadeild (HÍ)
Faculty of Physical Sciences (UI)
Series: Journal of Clinical Microbiology;56(12)
ISSN: 0095-1137
1098-660X (eISSN)
DOI: 10.1128/JCM.01046-18
Subject: Streptococcus pneumoniae; Carriage; Epidemiology; Molecular epidemiology; Otitis media; Pneumococcus; Vaccination; Vaccine; Pneumókokkar; Eyrnabólga; Bólusetningar; Bóluefni; Faraldsfræði
URI: https://hdl.handle.net/20.500.11815/1221

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Citation:

Quirk, S. J., Haraldsson, G., Erlendsdóttir, H., Hjálmarsdóttir, M. Á., van Tonder, A. J., Hrafnkelsson, B., . . . Kristinsson, K. G. (2018). Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland. Journal of Clinical Microbiology, 56(12), e01046-01018. doi:10.1128/jcm.01046-18

Abstract:

Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from children in Iceland. Pneumococci were collected between 2009 and 2017 from the nasopharynges of healthy children attending 15 day care centers and from the middle ears (MEs) of children with acute otitis media from the greater Reykjavik capital area. Isolates were serotyped and tested for antimicrobial susceptibility. Whole-genome sequencing (WGS) was performed on alternate isolates from 2009 to 2014, and serotypes and multilocus sequence types (STs) were extracted from the WGS data. Two study periods were defined: 2009 to 2011 (PreVac) and 2012 to 2017 (PostVac). The overall nasopharyngeal carriage rate was similar between the two periods (67.3% PreVac and 61.5% PostVac, P = 0.090). Vaccine-type (VT) pneumococci decreased and nonvaccine-type (NVT) pneumococci (serotypes 6C, 15A, 15B/C, 21, 22F, 23A, 23B, 35F, and 35B) significantly increased in different age strata post-PCV introduction. The total number of pneumococci recovered from ME samples significantly decreased as did the proportion that were VTs, although NVT pneumococci (6C, 15B/C, 23A, and 23B) increased significantly. Most serotype 6C pneumococci were multidrug resistant (MDR). Serotype 19F was the predominant serotype associated with MEs, and it significantly decreased post-PCV introduction: these isolates were predominantly MDR and of the Taiwan19F-14 PMEN lineage. Overall, the nasopharyngeal carriage rate remained constant and the number of ME-associated pneumococci decreased significantly post-PCV introduction; however, there was a concomitant and statistically significant shift from VTs to NVTs in both collections of pneumococci.

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