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Browsing by Subject "MITF"

Browsing by Subject "MITF"

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  • Ngeow, Kao Chin; Friedrichsen, Hans J.; Li, Linxin; Zeng, Zhiqiang; Andrews, Sarah; Volpon, Laurent; Brunsdon, Hannah; Berridge, Georgina; Picaud, Sarah; Fischer, Roman; Lisle, Richard; Knapp, Stefan; Filippakopoulos, Panagis; Knowles, Helen; Steingrimsson, Eirikur; Borden, Katherine L. B.; Patton, E. Elizabeth; Goding, Colin R. (Proceedings of the National Academy of Sciences, 2018-08-27)
    The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective ...
  • Ballesteros Álvarez, Josué A (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-01-10)
    The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to a larger family of basic helix-loop-helix leucine zipper transcription factors that are able to bind DNA and regulate gene expression. MITF is crucial for melanocyte development and has been ...
  • Remina, Dilixiati (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-03)
    The pigment producing melanocytes are derived from the neural crest cells and form precursor cells called melanoblasts. These cells proliferate and migrate to their destination in skin, hair and other organs where they differentiate into melanocytes ...