Opin vísindi

Browsing by Subject "Hematology"

Browsing by Subject "Hematology"

Sort by: Order: Results:

  • Icon
    Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes 
    Anastasopoulou, Stavroula; Nielsen, Rikke Linnemann; Als-Nielsen, Bodil; Banerjee, Joanna; Eriksson, Mats A.; Helenius, Marianne; Heyman, Mats M.; Johannsdottir, Inga Maria; Jónsson, Ólafur Gísli; MacGregor, Stuart; Mateos, Marion K.; Mayoh, Chelsea; Mikkel, Sirje; Myrberg, Ida Hed; Niinimäki, Riitta; Schmiegelow, Kjeld; Taskinen, Mervi; Vaitkeviciene, Goda; Warnqvist, Anna; Wolthers, Benjamin; Harila-Saari, Arja; Ranta, Susanna (2022-10)
    Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic ...
  • Icon
    Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol 
    Egnell, Christina; Närhinen, Hanna; Merker, Andrea; Jónsson, Ólafur Gísli; Lepik, Kristi; Niinimäki, Riitta; Schmiegelow, Kjeld; Stabell, Niklas; Klug Albertsen, Birgitte; Vaitkeviciene, Goda; Ranta, Susanna; Harila-Saari, Arja (2022-12)
    Objectives: Children with acute lymphoblastic leukemia (ALL) have a tendency to gain weight during treatment. As overweight and obesity associate with health problems, prophylactic interventions are warranted. Therefore, it is important to identify the ...
  • Icon
    Characteristics of white blood cell count in acute lymphoblastic leukemia : A COST LEGEND phenotype-genotype study 
    Helenius, Marianne; Vaitkeviciene, Goda; Abrahamsson, Jonas; Jónsson, Ólafur Gisli; Lund, Bendik; Harila-Saari, Arja; Vettenranta, Kim; Mikkel, Sirje; Stanulla, Martin; Lopez-Lopez, Elixabet; Waanders, Esmé; Madsen, Hans O; Marquart, Hanne Vibeke; Modvig, Signe; Gupta, Ramneek; Schmiegelow, Kjeld; Nielsen, Rikke Linnemann (2022-03-22)
    Background: White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome variants, is poorly understood. ...
  • Icon
    Correction : Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies (Blood Cancer Journal, (2021), 11, 5, (94), 10.1038/s41408-021-00480-w) 
    Rögnvaldsson, Sæmundur; Löve, Þorvarður Jón; Þorsteinsdóttir, Sigrún; Reed, Elín Ruth; Óskarsson, Jón Þórir; Pétursdóttir, Íris; Sigurðardóttir, Guðrún Ásta; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni Agnar; Sigurðardóttir, Margrét; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Þórðardóttir, Ásdís Rósa; Eyþórsson, Elías Sæbjörn; Jónsson, Ásbjörn; Björnsson, Andri Steinþór; Gunnarsson, Gunnar Þór; Pálsson, Runólfur; Indriðason, Ólafur Skúli; Gíslason, Gauti Kjartan; Ólafsson, Andri; Hákonardóttir, Guðlaug Katrín; Brinkhuis, Manje; Halldórsdóttir, Sara Lovísa; Ásgeirsdóttir, Tinna Laufey; Steingrímsdóttir, Hlíf; Danielsen, Ragnar; Wessman, Inga Dröfn; Kampanis, Petros; Hultcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Kristinsson, Sigurður Yngvi (2023-03-20)
    In this article the author name Malin Hultcrantz was incorrectly written as Malin Hulcrantz. The original article has been corrected.
  • Icon
    Defining new reference intervals for serum free light chains in individuals with chronic kidney disease : Results of the iStopMM study 
    Long, Þórir Einarsson; Indriðason, Ólafur Skúli; Pálsson, Runólfur; Rögnvaldsson, Sæmundur; Löve, Þorvarður Jón; Thorsteinsdóttir, Sigrún; Sverrisdóttir, Ingigerður S; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni Agnar; Sigurðardóttir, Margrét; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Thordardottir, Asdis Rosa; Eyþórsson, Elías Sæbjörn; Jónsson, Ásbjörn; Gíslason, Gauti Kjartan; Ólafsson, Andri; Steingrímsdóttir, Hlíf; Hultcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Kristinsson, Sigurður Yngvi (2022-09-14)
    Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish a reference interval for FLCs in persons with chronic kidney disease (CKD). A total of 75422 ...
  • Icon
    Fractures and survival in multiple myeloma : results from a population-based study 
    Thorsteinsdottir, Sigrun; Gislason, Gauti; Aspelund, Thor; Sverrisdottir, Ingigerdur; Landgren, Ola; Turesson, Ingemar; Björkholm, Magnus; Kristinsson, Sigurður Yngvi (2020-04-01)
    Multiple myeloma causes lytic bone lesions and fractures. The impact of fractures on multiple myeloma (MM) survival is unclear. The aim of this study was to evaluate the effect of fractures on survival in MM using data from MM patients diagnosed in ...
  • Icon
    Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia 
    Karlsson, Lene; Nyvold, Charlotte Guldborg; Soboli, Anastasia; Johansson, Pegah; Palmqvist, Lars; Tierens, Anne; Hasle, Henrik; Lausen, Birgitte; Jónsson, Ólafur Gísli; Jürgensen, Gitte Wulff; Ebbesen, Lene Hyldahl; Abrahamsson, Jonas; Fogelstrand, Linda (2022-12)
    Introduction: Analysis of measurable residual disease (MRD) is increasingly being implemented in the clinical care of children and adults with acute myeloid leukaemia (AML). However, MRD methodologies differ and discordances in results lead to difficulties ...
  • Icon
    Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial 
    Norén-Nyström, Ulrika; Andersen, Mette K; Barbany, Gisela; Dirse, Vaidas; Eilert-Olsen, Martine; Engvall, Marie; Harila-Saari, Arja; Heyman, Mats; Hovland, Randi; Häikiö, Satu; Jónsson, Jón Jóhannes; Karhu, Ritva; Kjeldsen, Eigil; Norberg, Anna; Preiss, Birgitte S; Pulkkinen, Kati; Quist-Paulsen, Petter; Räsänen, Hannele; Schmiegelow, Kjeld; Seitsonen, Anne; Sjögren, Helene; Tammur, Pille; Johansson, Bertil (2023-05-04)
  • Icon
    Germline variants at SOHLH2 influence multiple myeloma risk 
    Duran-Lozano, Laura; Thorleifsson, Gudmar; Lopez de Lapuente Portilla, Aitzkoa; Niroula, Abhishek; Went, Molly; Thodberg, Malte; Pertesi, Maroulio; Ajore, Ram; Cafaro, Caterina; Olason, Pall I.; Stefansdottir, Lilja; Bragi Walters, G.; Halldorsson, Gisli H.; Turesson, Ingemar; Kaiser, Martin F.; Weinhold, Niels; Abildgaard, Niels; Andersen, Niels Frost; Mellqvist, Ulf Henrik; Waage, Anders; Juul-Vangsted, Annette; Thorsteinsdottir, Unnur; Hansson, Markus; Houlston, Richard; Rafnar, Thorunn; Stefansson, Kari; Nilsson, Björn (2021-04)
    Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a genome-wide association study ...
  • Icon
    Iceland screens, treats, or prevents multiple myeloma (iStopMM) : a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies 
    Rögnvaldsson, Sæmundur; Love, Thorvardur Jon; Thorsteinsdottir, Sigrun; Reed, Elín Ruth; Óskarsson, Jón Þórir; Pétursdóttir, Íris; Sigurðardóttir, Guðrún Ásta; Viðarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni A.; Þorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Þórðardóttir, Ásdís Rósa; Eyþórsson, Elías; Jónsson, Ásbjörn; Björnsson, Andri S.; Gunnarsson, Gunnar Þór; Pálsson, Runólfur; Indriðason, Ólafur Skúli; Gíslason, Gauti Kjartan; Ólafsson, Andri; Hákonardóttir, Guðlaug Katrín; Brinkhuis, Manje; Halldórsdóttir, Sara Lovísa; Ásgeirsdóttir, Tinna Laufey; Steingrímsdóttir, Hlíf; Danielsen, Ragnar; Dröfn Wessman, Inga; Kampanis, Petros; Hulcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Kristinsson, Sigurður Yngvi (2021-05-17)
    Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma ...
  • Icon
    Monoclonal gammopathy of undetermined significance and COVID-19 : a population-based cohort study 
    Rögnvaldsson, Sæmundur; Eythorsson, Elias; Thorsteinsdottir, Sigrun; Vidarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni Agnar; Sigurdardottir, Margret; Thorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Runólfsdóttir, Hrafnhildur L.; Helgason, Dadi; Emilsdóttir, Arna Rut; Ágústsson, Arnar Snær; Björnsson, Aron Hjalti; Kristjánsdóttir, Gudrún; Thordardottir, Asdis Rosa; Indridason, Olafur Skuli; Jónsson, Ásbjörn; Gislason, Gauti Kjartan; Olafsson, Andri; Steingrímsdóttir, Hlíf; Kampanis, Petros; Hultcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Palsson, Runolfur; Love, Thorvarður Jon; Kristinsson, Sigurdur Yngvi (2021-12-01)
    Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of ...
  • Icon
    Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer 
    OlympiA Clinical Trial Steering Committee and Investigators (2022-12-01)
    Background: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in ...
  • Icon
    Peripheral neuropathy and monoclonal gammopathy of undetermined significance : A population-based study including 15,351 cases and 58,619 matched controls 
    Rögnvaldsson, Sæmundur; Steingrímsson, Vilhjálmur; Turesson, Ingemar; Björkholm, Magnus; Landgren, Ola; Kristinsson, Sigurður Yngvi (2020-11)
  • Icon
    Recommendations for in vitro evaluation of blood components collected, prepared and stored in non-DEHP medical devices 
    Klei, Thomas R L; Begue, Stephane; Lotens, Anaïs; Sigurjónsson, Ólafur Eysteinn; Wiltshire, Michael D; George, Chloë; van den Burg, Peter J M; Evans, Ryan; Larsson, Linda; Thomas, Stephen; Najdovski, Tome; Handke, Wiebke; Eronen, Juha; Mallas, Birte; de Korte, Dirk (2023-02)
    BACKGROUND AND OBJECTIVES: DEHP, di(2-ethylhexyl) phthalate, is the most common member of the class of ortho-phthalates, which are used as plasticizers. The Medical Device Regulation has restricted the use of phthalates in medical devices. Also DEHP ...
  • Icon
    Replacement of traditional prothrombin time monitoring with the new Fiix prothrombin time increases the efficacy of warfarin without increasing bleeding. A review article 
    Önundarson, Páll Torfi; Palsson, Ragnar; Witt, Daniel M.; Gudmundsdottir, Brynja R. (2021-10-15)
    The antithrombotic effect of vitamin K antagonists (VKA) depends on controlled lowering of the activity of factors (F) II and X whereas reductions in FVII and FIX play little role. PT-INR based monitoring, however, is highly influenced by FVII, which ...