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Brain ventricle parcellation using a deep neural network: Application to patients with ventriculomegaly

Shao, Muhan; Han, Shuo; Carass, Aaron; Li, Xiang; Blitz, Ari M.; Shin, Jaehoon; Prince, Jerry L.; Ellingsen, Lotta María (Elsevier BV, 2019)

Numerous brain disorders are associated with ventriculomegaly, including both neuro-degenerative diseases and cerebrospinal fluid disorders. Detailed evaluation of the ventricular system is important for these conditions to help understand the pathogenesis ...
Incidence of Brain Infarcts, Cognitive Change, and Risk of Dementia in the General Population : The AGES-Reykjavik Study (Age Gene/Environment Susceptibility-Reykjavik Study)

Sigurdsson, Sigurdur; Aspelund, Thor; Kjartansson, Ólafur; Gudmundsson, Elias Freyr; Jónsdóttir, María Kristín; Eiríksdóttir, Guðný; Jónsson, Pálmi V; van Buchem, Mark A.; Guðnason, Vilmundur G; Launer, Lenore J. (2017-09)

BACKGROUND AND PURPOSE: The differentiation of brain infarcts by region is important because their cause and clinical implications may differ. Information on the incidence of these lesions and association with cognition and dementia from longitudinal ...
Lifestyle and 25-hydroxyvitamin D, and its associations with cognitive function among Icelandic older adults: AGES-Reykjavik study

Eymundsdóttir, Hrafnhildur (University of Iceland, School of Health Sciences, Food Science and Nutrition, 2020-06)

Aims: The aim of this thesis was to evaluate lifestyle factors and the associations with cognitive function and the development of dementia among older adults with special considerations for vitamin D, physical activity and body mass index. Additionally, ...
Maintaining or letting go of couplehood : Perspectives of older male spousal dementia caregivers

Stefánsdóttir, Olga Ásrún; Munkejord, Mai Camilla; Sveinbjarnardóttir, Eydís Kristín (2021-09-26)

Despite the negative implications for their own health, spouses continue to support each other and maintain their couplehood for as long as possible, including when one of them develops a severe illness. However, with some exceptions, the experiences ...
Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Activity for the Treatment of Neurodegenerative Disorders

Kowal, Natalia Magdalena; Indurthi, Dinesh; Ahring, Philip; Chebib, Mary; Olafsdottir, Elin Soffia; Balle, Thomas (MDPI AG, 2019-01-27)

Neurodegenerative disorders, including Alzheimer’s disease, belong to the group of the most difficult and challenging conditions with very limited treatment options. Attempts to find new drugs in most cases fail at the clinical stage. New tactics to ...
Retinal oxygen metabolism in patients with mild cognitive impairment

Ólafsdóttir, Ólöf Birna; Sævarsdóttir, Hrafnhildur Sif; Hardarson, Sveinn Hakon; Hannesdóttir, Kristín Hanna; Traustadóttir, Valgerður Dóra; Karlsson, Róbert Arnar; Einarsdóttir, Anna Bryndís; Jónsdóttir, Katrin Diljá; Stefánsson, Einar; Snædal, Jon (Elsevier BV, 2018)

Introduction We have previously reported that retinal vessel oxygen saturation is increased in mild-to-moderate dementia of Alzheimer's type when compared with healthy individuals. Mild cognitive impairment (MCI) is the predementia stage of the disease. ...
Twenty-seven-year time trends in dementia incidence in Europe and the United States : The Alzheimer Cohorts Consortium

Wolters, Frank J.; Chibnik, Lori B.; Waziry, Reem; Anderson, Roy; Berr, Claudine; Beiser, Alexa; Bis, Joshua C.; Blacker, Deborah; Bos, Daniel; Brayne, Carol; Dartigues, Jean François; Darweesh, Sirwan K.L.; Davis-Plourde, Kendra L.; de Wolf, Frank; Debette, Stephanie; Dufouil, Carole; Fornage, Myriam; Goudsmit, Jaap; Grasset, Leslie; Guðnason, Vilmundur G.; Hadjichrysanthou, Christoforos; Helmer, Catherine; Ikram, M. Arfan; Ikram, M. Kamran; Joas, Erik; Kern, Silke; Kuller, Lewis H.; Launer, Lenore; Lopez, Oscar L.; Matthews, Fiona E.; McRae-McKee, Kevin; Meirelles, Osorio; Mosley, Thomas H.; Pase, Matthew P.; Psaty, Bruce M.; Satizabal, Claudia L.; Seshadri, Sudha; Skoog, Ingmar; Stephan, Blossom C.M.; Wetterberg, Hanna; Wong, Mei Mei; Zettergren, Anna; Hofman, Albert (2020-08-04)

OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the ...

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