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Fletta eftir efnisorði "Húðkrabbamein"

Fletta eftir efnisorði "Húðkrabbamein"

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    BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export 
    Ngeow, Kao Chin; Friedrichsen, Hans J.; Li, Linxin; Zeng, Zhiqiang; Andrews, Sarah; Volpon, Laurent; Brunsdon, Hannah; Berridge, Georgina; Picaud, Sarah; Fischer, Roman; Lisle, Richard; Knapp, Stefan; Filippakopoulos, Panagis; Knowles, Helen; Steingrimsson, Eirikur; Borden, Katherine L. B.; Patton, E. Elizabeth; Goding, Colin R. (Proceedings of the National Academy of Sciences, 2018-08-27)
    The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective ...
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    BRN2 is a non-canonical melanoma tumor-suppressor 
    Hamm, Michael; Sohier, Pierre; Petit, Valérie; Raymond, Jérémy H.; Delmas, Véronique; Le Coz, Madeleine; Gesbert, Franck; Kenny, Colin; Aktary, Zackie; Pouteaux, Marie; Rambow, Florian; Sarasin, Alain; Charoenchon, Nisamanee; Bellacosa, Alfonso; Sanchez-del-Campo, Luis; Mosteo, Laura; Lauss, Martin; Meijer, Dies; Steingrímsson, Eiríkur; Jönsson, Göran B.; Cornell, Robert A.; Davidson, Irwin; Goding, Colin R.; Larue, Lionel (2021-06-17)
    While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
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    Geothermal areas and cancer 
    Kristbjornsdottir, Adalbjorg (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
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    Incidence of cancer among licenced commercial pilots flying North Atlantic routes 
    Guðmundsdóttir, Eva María; Hrafnkelsson, Jón; Rafnsson, Vilhjalmur (Springer Nature, 2017-08-16)
    Background: To evaluate cancer incidence among licenced commercial pilots in association with cosmic radiation. Methods: Cohort study where ionizing radiation dose of cosmic radiation was estimated from airline data and software program and cancer ...
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    MITF has a central role in regulating starvation-induced autophagy in melanoma 
    Möller, Katrin; Sigurbjornsdottir, Sara; Arnþórsson, Ásgeir O.; Pogenberg, Vivian; Dilshat, Ramile; Fock, Valerie; Brynjólfsdóttir, Sólveig Hlín; Bindesboll, Christian; Bessadóttir, Margrét; Ögmundsdóttir, Helga M.; Simonsen, Anne; Larue, Lionel; Wilmanns, Matthias; Thorsson, Vésteinn; Steingrimsson, Eirikur; Ogmundsdottir, Margret H (Springer Science and Business Media LLC, 2019-01-31)
    The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in ...
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    A network of bHLHZip transcription factors in melanoma: Interactions of MITF, TFEB and TFE3 
    Ballesteros Álvarez, Josué A (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-01-10)
    The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to a larger family of basic helix-loop-helix leucine zipper transcription factors that are able to bind DNA and regulate gene expression. MITF is crucial for melanocyte development and has been ...
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    The role of MITF in regulating transcriptional cell states in melanoma 
    Remina, Dilixiati (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-03)
    The pigment producing melanocytes are derived from the neural crest cells and form precursor cells called melanoblasts. These cells proliferate and migrate to their destination in skin, hair and other organs where they differentiate into melanocytes ...