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Fletta eftir efnisorði "Genetic Predisposition to Disease"

Fletta eftir efnisorði "Genetic Predisposition to Disease"

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    Sequence variants associated with BMI affect disease risk through BMI itself 
    Einarsson, Gudmundur; Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Zink, Florian; Helgason, Hannes; Olafsdottir, Thorhildur; Rognvaldsson, Solvi; Tragante, Vinicius; Ulfarsson, Magnus O; Sveinbjornsson, Gardar; Snaebjarnarson, Audunn S; Einarsson, Hafsteinn; Ægisdóttir, Hildur Margrét; Jonsdottir, Gudrun A; Helgadottir, Anna; Gretarsdottir, Solveig; Styrkarsdottir, Unnur; Arnason, Hannes K; Bjarnason, Ragnar Grímur; Sigurdsson, Emil; Arnar, Davíð Ottó; Björnsson, Einar Stefán; Pálsson, Runólfur; Bjornsdottir, Gyda; Stefansson, Hreinn; Thorgeirsson, Thorgeir; Sulem, Patrick; Þorsteinsdóttir, Unnur; Holm, Hilma; Gudbjartsson, Daniel F; Stefánsson, Kári (2024-11-12)
    Mendelian Randomization studies indicate that BMI contributes to various diseases, but it's unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence variants is mediated through BMI or ...
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    Sequence variants influencing the regulation of serum IgG subclass levels 
    Ólafsdóttir, Þórunn Ásta; Thorleifsson, Gudmar; Lopez de Lapuente Portilla, Aitzkoa; Jonsson, Stefan; Stefánsdóttir, Lilja; Niroula, Abhishek; Jonasdottir, Aslaug; Eggertsson, Hannes P.; Halldórsson, Gísli Hreinn; Thorlacius, Gudny E.; Arnthorsson, Asgeir O.; Björnsdóttir, Unnur Steina; Asselbergs, Folkert W.; Bentlage, Arthur E.H.; Eyjolfsson, Gudmundur I.; Gudmundsdottir, Steinunn; Gunnarsdottir, Kristbjorg; Halldórsson, Bjarni Vilhjálmur; Holm, Hilma; Lúðvíksson, Björn Rúnar; Melsted, Páll; Norddahl, Gudmundur L.; Ólafsson, Ísleifur; Saevarsdottir, Saedis; Sigurdardottir, Olof; Sigurdsson, Asgeir; Temming, Robin; Önundarson, Páll Torfi; Þorsteinsdóttir, Unnur; Vidarsson, Gestur; Sulem, Patrick; Gudbjartsson, Daniel F.; Jónsdóttir, Ingileif; Nilsson, Björn; Stefánsson, Kári (2024-12)
    Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on ...