Opin vísindi

Browsing by Subject "Drug Discovery"

Browsing by Subject "Drug Discovery"

Sort by: Order: Results:

  • Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
  • Kallab, Martin; Schuetzenberger, Kornelia; Hommer, Nikolaus; Schäfer, Bhavapriya Jasmin; Schmidl, Doreen; Bergmeister, Helga; Zeitlinger, Markus; Tan, Aimin; Jansook, Phatsawee; Loftsson, Þorsteinn; Stefánsson, Einar; Garhöfer, Gerhard (2021-05-18)
    The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in ...
  • Kulkarni, Amogh; Soni, Isha; Kelkar, Dhanashree S.; Dharmaraja, Allimuthu T.; Sankar, Rathinam K.; Beniwal, Gaurav; Rajendran, Abinaya; Tamhankar, Sharvari; Chopra, Sidharth; Kamat, Siddhesh S.; Chakrapani, Harinath (American Chemical Society (ACS), 2019-06-26)
    The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S. aureus) infections has underscored a need to develop new therapies to address this epidemic. Chemoproteomics is valuable in identifying targets for new drugs in ...
  • Eiríksdóttir, Heiðrún; Stefánsson, Magnús Örn; Einarsson, Hjörleifur (2021)
    The demand for novel sources of marine oils, which contain polyunsaturated fatty acids (PUFAs), has increased due to the realization of the importance of PUFAs, e.g., docosahexaenoic acid (DHA), in the human diet. However, the natural supply is limited. ...
  • Castejón, Natalia; Þórarinsdóttir, Kristín Anna; Einarsdóttir, Ragnhildur; Kristbergsson, Kristberg; Marteinsdóttir, Guðrún (2021-11-25)
    A growing concern for overall health is driving a global market of natural ingredients not only in the food industry but also in the cosmetic field. In this study, a screening on potential cosmetic applications of aqueous extracts from three Icelandic ...
  • Drobnjak, Tijana; Meiri, Hamutal; Mandalá, Maurizio; Huppertz, Berthold; Gizurarson, Sveinbjorn (Dove Medical Press Ltd., 2018-07)
    Introduction: Human placental protein 13 (PP13) is a galectin predominantly expressed by the placenta. Low serum concentrations of PP13 in early pregnancy indicate a higher risk of developing preeclampsia. Methods: The pharmacokinetic disposition ...
  • Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit (2021-03-03)
    T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel ...