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Fletta eftir titli tímarits "Molecular Psychiatry"

Fletta eftir titli tímarits "Molecular Psychiatry"

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    Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders 
    Andlauer, Till F. M.; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2019-11-11)
    Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is ...
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    Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia 
    Sønderby, Ida E; Ulfarsson, Magnus; Walters, G. Bragi; Stefansson, Kari (Springer Science and Business Media LLC, 2018-10-03)
    Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes ...
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    A polygenic resilience score moderates the genetic risk for schizophrenia 
    Hess, Jonathan L.; Sigurdsson, Engilbert; Stefansson, Hreinn; Stefansson, Kari (Springer Science and Business Media LLC, 2019-09-06)
    Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants ...