Opin vísindi

Browsing by Author "Steingrimsson, Eirikur"

Browsing by Author "Steingrimsson, Eirikur"

Sort by: Order: Results:

  • Ngeow, Kao Chin; Friedrichsen, Hans J.; Li, Linxin; Zeng, Zhiqiang; Andrews, Sarah; Volpon, Laurent; Brunsdon, Hannah; Berridge, Georgina; Picaud, Sarah; Fischer, Roman; Lisle, Richard; Knapp, Stefan; Filippakopoulos, Panagis; Knowles, Helen; Steingrimsson, Eirikur; Borden, Katherine L. B.; Patton, E. Elizabeth; Goding, Colin R. (Proceedings of the National Academy of Sciences, 2018-08-27)
    The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective ...
  • Pallares, Luisa F; Ledevin, Ronan; Pantalacci, Sophie; Turner, Leslie M; Steingrimsson, Eirikur; Renaud, Sabrina (eLife Sciences Organisation, Ltd., 2017-11-01)
    Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the ...
  • García-Llorca, Andrea; Gudmundsdottir Aspelund, Snaefridur; Ogmundsdottir, Margret H; Steingrimsson, Eirikur; Eysteinsson, Thor (Springer Science and Business Media LLC, 2019-10-28)
    Mutations in the microphthalmia-associated transcription factor (Mitf) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and degeneration. We examined retinal and RPE structure and function in 3 month old mice homo- or heterozygous ...
  • Möller, Katrin; Sigurbjornsdottir, Sara; Arnþórsson, Ásgeir O.; Pogenberg, Vivian; Dilshat, Ramile; Fock, Valerie; Brynjólfsdóttir, Sólveig Hlín; Bindesboll, Christian; Bessadóttir, Margrét; Ögmundsdóttir, Helga M.; Simonsen, Anne; Larue, Lionel; Wilmanns, Matthias; Thorsson, Vésteinn; Steingrimsson, Eirikur; Ogmundsdottir, Margret H (Springer Science and Business Media LLC, 2019-01-31)
    The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in ...
  • Zhang, T.; Zhou, Q.; Ogmundsdottir, Margret H; Möller, Katrin; Siddaway, R.; Larue, L.; Hsing, M.; Kong, S. W.; Goding, C. R.; Palsson, Arnar; Steingrimsson, Eirikur; Pignoni, F. (The Company of Biologists, 2015-06-19)
    The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we ...
  • Atacho, Diahann A. M.; Reynisson, Hallur; Pétursdóttir, Anna Þóra; Eysteinsson, Thor; Steingrimsson, Eirikur; Petersen, Petur Henry (Society for Neuroscience, 2020-03)
    Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (Mitf) plays a central role in intrinsic plasticity of olfactory bulb ...
  • Ogmundsdottir, Margret H; Fock, Valerie; Sooman, L.; Pogenberg, V.; Dilshat, R.; Bindesbøll, C.; Ögmundsdóttir, Helga M.; Simonsen, A.; Wilmanns, M.; Steingrimsson, Eirikur (Springer Science and Business Media LLC, 2018-09-26)
    Autophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing ...