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Browsing by Author "Steingrimsson, Eirikur"

Browsing by Author "Steingrimsson, Eirikur"

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  • Ngeow, Kao Chin; Friedrichsen, Hans J.; Li, Linxin; Zeng, Zhiqiang; Andrews, Sarah; Volpon, Laurent; Brunsdon, Hannah; Berridge, Georgina; Picaud, Sarah; Fischer, Roman; Lisle, Richard; Knapp, Stefan; Filippakopoulos, Panagis; Knowles, Helen; Steingrimsson, Eirikur; Borden, Katherine L. B.; Patton, E. Elizabeth; Goding, Colin R. (Proceedings of the National Academy of Sciences, 2018-08-27)
    The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial posttranslational modification of key lineage-specific transcription factors would be an effective ...
  • Pallares, Luisa F; Ledevin, Ronan; Pantalacci, Sophie; Turner, Leslie M; Steingrimsson, Eirikur; Renaud, Sabrina (eLife Sciences Organisation, Ltd., 2017-11-01)
    Numerous loci of large effect have been shown to underlie phenotypic variation between species. However, loci with subtle effects are presumably more frequently involved in microevolutionary processes but have rarely been discovered. We explore the ...
  • Ogmundsdottir, Margret H; Fock, V.; Sooman, L.; Pogenberg, V.; Dilshat, R.; Bindesbøll, C.; Ogmundsdottir, H. M.; Simonsen, A.; Wilmanns, M.; Steingrimsson, Eirikur (Springer Science and Business Media LLC, 2018-09-26)
    Autophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing ...