Most enzymes are homodimers or higher order multimers. Cold‐active alkaline phosphatase from Vibrio splendidus (VAP) transitions into a dimer with very low activity under mild denaturation conditions. The desire to understand why this dimer fails to ...

Protein quaternary structures are fundament for life. Proteins have evolved towards large assemblies of subunits needed for the execution of complex chemistry, for building structural components or for compartmentalization. Most oligomeric enzymes ...