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Browsing by Author "Haraldsson, Ásgeir"

Browsing by Author "Haraldsson, Ásgeir"

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  • Hjálmarsdóttir, Martha Ásdís; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Haraldsson, Ásgeir; Kristinsson, Karl G. (Public Library of Science (PLoS), 2017-01-26)
    Background Information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. The aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (ME), lower respiratory ...
  • Levy, Marína Rós; Thors, Valtýr Stefánsson; Elínardóttir, Sigríður Haralds; Möller, Alma D.; Haraldsson, Ásgeir (2021-09-30)
    Background Global death rate in children has been declining during the last decades worldwide, especially in high income countries. This has been attributed to several factors, including improved prenatal and perinatal care, immunisations, infection ...
  • Sveinsdóttir, Hildigunnur; Björnsdóttir, Jana Birta; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; Hrafnkelsson, Birgir; Haraldsson, Ásgeir; Kristinsson, Karl G.; Haraldsson, Gunnsteinn (American Society for Microbiology, 2019-05-08)
    Vaccinations with the 10-valent pneumococcal conjugated vaccine (PHiD-CV) started in Iceland in 2011. Protein D (PD) from H. influenzae, which is coded for by the hpd gene, is used as a conjugate in the vaccine and may provide protection against ...
  • Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; van Tonder, Andries J.; Hrafnkelsson, Birgir; Sigurdsson, Samuel; Bentley, Stephen D.; Haraldsson, Ásgeir; Brueggemann, Angela B.; Kristinsson, Karl G. (American Society for Microbiology, 2018-09-26)
    Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from ...
  • van Tonder, Andries J.; Bray, James E.; Jolley, Keith A.; Jansen van Rensburg, Melissa; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Maiden, Martin; Bentley, Stephen D.; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl G.; Brueggemann, Angela B. (Frontiers Media SA, 2019-02-25)
    Understanding the structure of a bacterial population is essential in order to understand bacterial evolution. Estimating the core genome (those genes common to all, or nearly all, strains of a species) is a key component of such analyses. The size and ...
  • Bæringsdóttir, Birta; Erlendsdóttir, Helga; Björnsdóttir, Erla Soffía; Martins, Elisabete R.; Ramirez, Mário; Haraldsson, Ásgeir; Þórkelsson, Þórður (2021-09-23)
    Introduction. Group B streptococcus (GBS) is a leading cause of invasive neonatal infections. These have been divided into early-onset disease (EOD; <7 days) and late-onset disease (LOD; 7–89 days), with different GBS clonal complexes (CCs) associated ...
  • Harrison, Stephanie C.; Tsilifis, Christo; Slatter, Mary A.; Nademi, Zohreh; Worth, Austen; Veys, Paul; Ponsford, Mark J.; Jolles, Stephen; Al-Herz, Waleed; Flood, Terence; Cant, Andrew J.; Doffinger, Rainer; Barcenas-Morales, Gabriela; Carpenter, Ben; Hough, Rachael; Haraldsson, Ásgeir; Heimall, Jennifer; Grimbacher, Bodo; Abinun, Mario; Gennery, Andrew R. (2021-02-01)
    Autosomal dominant hyper-IgE syndrome caused by dominant-negative loss-of-function mutations in signal transducer and activator of transcription factor 3 (STAT3) (STAT3-HIES) is a rare primary immunodeficiency with multisystem pathology. The quality ...
  • Arnadottir, Gudny; Norðdahl, Guðmundur L.; Gudmundsdottir, Steinunn; Ágústsdóttir, Arna B.; Sigurðsson, Snævar; Jensson, Brynjar Örn; Bjarnadóttir, Kristbjörg; Theodórs, Fannar; Benonisdottir, Stefania; Ívarsdóttir, Erna V.; Oddsson, Asmundur; Kristjánsson, Ragnar P.; Sulem, Gerald; Alexandersson, Kristján F.; Júlíusdóttir, Þórhildur; Guðmundsson, Kjartan R.; Sæmundsdóttir, Jóna; Jónasdóttir, Aðalbjörg; Jónasdóttir, Áslaug; Sigurðsson, Ásgeir; Manzanillo, Paolo; Guðjónsson, Sigurjón Axel; Thorisson, Gudmundur A.; Magnússon, Ólafur Þ.; Másson, Gísli; Örvar, Kjartan B.; Holm, Hilma; Björnsson, Sigurður; Arngrimsson, Reynir; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Haraldsson, Ásgeir; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2018-10-25)
    Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are recognized to cause chronic granulomatous disease (CGD), a severe primary immunodeficiency. Here we describe how deficiency of CYBC1, a previously uncharacterized protein ...
  • Eyþórsson, Elías; Sigurdsson, Samuel; Hrafnkelsson, Birgir; Erlendsdóttir, Helga; Haraldsson, Ásgeir; Kristinsson, Karl G. (Springer Science and Business Media LLC, 2018-10-04)
    Background: Antimicrobial resistance is a public-health threat and antimicrobial consumption is the main contributor. The ten-valent pneumococcal conjugate vaccine (PHiD-CV10) was introduced into the Icelandic vaccination program in 2011. The aim ...
  • Sigurdsson, Samuel; Eyþórsson, Elías; Erlendsdóttir, Helga; Hrafnkelsson, Birgir; Kristinsson, Karl G.; Haraldsson, Ásgeir (Elsevier BV, 2020-03-10)
    Introduction: Pneumococcus is an important respiratory pathogen. The 10-valent pneumococcal vaccine (PHiD-CV) was introduced into the Icelandic vaccination programme in 2011. The aim was to estimate the impact of PHiD-CV on paediatric hospitalisations ...
  • Eyþórsson, Elías; Sigurdsson, Samuel; Erlendsdóttir, Helga; Hrafnkelsson, Birgir; Kristinsson, Karl G.; Haraldsson, Ásgeir (Wiley, 2019-01-22)
    Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland. Methods: This population-based observational cohort study followed 11 consecutive ...
  • Sigurdsson, Samuel; Erlendsdóttir, Helga; Quirk, Sigríður Júlía; Kristjánsson, Júlíus; Hauksson, Kristján; Andrésdóttir, Birta Dögg Ingudóttir; Jónsson, Arnar Jan; Halldórsson, Kolbeinn Hans; Saemundsson, Arni; Ólason, Óli Hilmar; Hrafnkelsson, Birgir; Kristinsson, Karl G.; Haraldsson, Ásgeir (Elsevier BV, 2017-09)
    Background Since the introduction of pneumococcal conjugate vaccines, vaccine type pneumococcal carriage and disease has decreased world-wide. The aim was to monitor changes in the nasopharyngeal carriage of pneumococci, the distribution of serotypes ...
  • Hjálmarsdóttir, Martha Ásdís; Haraldsson, Gunnsteinn Ægir; Quirk, Sigríður Júlía; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl Gústaf (2020)
    Background Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of acute otitis media. The 10-valent protein conjugated pneumococcal vaccine (PHiD-CV) ...