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Browsing by Author "Sigurðsson, Stefán"

Browsing by Author "Sigurðsson, Stefán"

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    CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer 
    Stefansson, Olafur; Hermanowicz, Stefan; van der Horst, Jasper; Hilmarsdóttir, Hólmfríður; Staszczak, Zuzanna; Jónasson, Jón Gunnlaugur; Tryggvadottir, Laufey; Guðjónsson, Þorkell; Sigurðsson, Stefán (Springer Nature, 2017-07-05)
    Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ...
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    Northern lights assay: a versatile method for comprehensive detection of DNA damage 
    Guðmundsson, Bjarki; Þormar, Hans G; Sigurðsson, Albert; Dankers, Wendy; Steinarsdóttir, Margrét; Hermanowicz, Stefan; Sigurðsson, Stefán; Ólafsson, Davið; Halldorsdottir, Anna; Meyn, Stephen; Jonsson, Jon J. (Oxford University Press (OUP), 2018-07-24)
    DNA damage assays have various limitations in types of lesions detected, sensitivity, specificity and samples that can be analyzed. The Northern Lights Assay (NLA) is based on 2D Strandness-Dependent Electrophoresis (2D-SDE), a technique that separates ...