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    The association of degree of polypharmacy before and after among hospitalised internal medicine patients and clinical outcomes : a retrospective, population-based cohort study 
    Jónsdóttir, Freyja; Blöndal, Anna Bryndís; Guðmundsson, Aðalsteinn; Bates, Ian; Stevenson, Jennifer Mary; Sigurðsson, Martin Ingi (2024-03-28)
    Objectives To determine the prevalence and incidence of polypharmacy/hyperpolypharmacy and which medications are most prescribed to patients with varying burden of polypharmacy. Design Retrospective, population-based cohort study. Setting Iceland. ...
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    Association of Dietary Patterns With Testicular Function in Young Danish Men 
    Nassan, Feiby L.; Jensen, Tina K.; Priskorn, Lærke; Halldorsson, Thorhallur; Chavarro, Jorge E.; Jørgensen, Niels (American Medical Association (AMA), 2020-02-21)
    Importance: Diet may play a role in testicular function, but data on how adherence to different diet patterns influences human testicular function are scarce. Objective: To determine whether adherence to specific dietary patterns is associated with ...
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    Association of Dual Decline in Memory and Gait Speed With Risk for Dementia Among Adults Older Than 60 Years 
    Tian, Qu; Resnick, Susan M.; Mielke, Michelle M.; Yaffe, Kristine; Launer, Lenore J.; Jónsson, Pálmi V.; Grande, Giulia; Welmer, Anna-Karin; Laukka, Erika J.; Bandinelli, Stefania; Cherubini, Antonio; Rosano, Caterina; Kritchevsky, Stephen B.; Simonsick, Eleanor M.; Studenski, Stephanie A.; Ferrucci, Luigi (American Medical Association (AMA), 2020-02-21)
    Importance: Dual decline in both memory and gait speed may characterize a group of older individuals at high risk for future dementia. Objective: To assess the risk of dementia in older persons who experience parallel declines in memory and gait speed ...
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    Association of eGFR and mortality with use of a joint model : results of a nationwide study in Iceland 
    Jónsson, Arnar Jan; Lund, Sigrún Helga; Eriksen, Bjørn O; Pálsson, Runólfur; Indriðason, Ólafur Skúli (2023-09-29)
    OBJECTIVES: Prior studies on the association of estimated glomerular filtration rate (eGFR) and mortality have failed to include methods to account for repeated eGFR determinations. The aim of this study was to estimate the association between eGFR and ...
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    Association of energy and protein intakes with length of stay, readmission and mortality in hospitalised patients with chronic obstructive pulmonary disease 
    Ingadottir, Arora Ros; Beck, Anne M.; Baldwin, Christine; Weekes, C. Elizabeth; Geirsdottir, Olof; Ramel, Alfons; Gislason, Thorarinn; Gunnarsdottir, Ingibjorg (Cambridge University Press (CUP), 2018-03-06)
    Low energy and protein intakes have been associated with an increased risk of malnutrition in outpatients with chronic obstructive pulmonary disease (COPD). We aimed to assess the energy and protein intakes of hospitalised COPD patients according to ...
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    Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis 
    Chen, Hao Yu; Cairns, Benjamin J.; Small, Aeron M.; Burr, Hannah A.; Ambikkumar, Athithan; Martinsson, Andreas; Thériault, Sébastien; Munter, Hans Markus; Steffen, Brian; Zhang, Richard; Levinson, Rebecca T.; Shaffer, Christian M.; Rong, Jian; Sonestedt, Emily; Dufresne, Line; Ljungberg, Johan; Näslund, Ulf; Johansson, Bengt; Ranatunga, Dilrini K.; Whitmer, Rachel A.; Budoff, Matthew J.; Nguyen, Albert; Vasan, Ramachandran S.; Larson, Martin G.; Harris, William S.; Damrauer, Scott M.; Stark, Ken D.; Boekholdt, S. Matthijs; Wareham, Nicholas J.; Pibarot, Philippe; Arsenault, Benoit J.; Mathieu, Patrick; Gudnason, Vilmundur; O’Donnell, Christopher J.; Rotter, Jerome I.; Tsai, Michael Y.; Post, Wendy S.; Clarke, Robert; Söderberg, Stefan; Bossé, Yohan; Wells, Quinn S.; Smith, J. Gustav; Rader, Daniel J.; Lathrop, Mark; Engert, James C.; Thanassoulis, George (American Medical Association (AMA), 2020-06-01)
    Importance: Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets. Objective: To identify novel genetic loci and pathways associated with AS. Design, Setting, and Participants: ...
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    Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis : results from the SWEFOT trial population 
    for the SWEFOT study group (2019-09-03)
    Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and ...
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    Association of Genetically Predicted Lipid Levels With the Extent of Coronary Atherosclerosis in Icelandic Adults 
    Björnsson, Eyþór; Þorleifsson, Guðmar; Helgadóttir, Anna; Gudnason, Thorarinn; Gudbjartsson, Tomas; Andersen, Karl; Grétarsdóttir, Sólveig; Ólafsson, Ísleifur; Tragante, Vinicius; Ólafsson, Ólafur Hreiðar; Jónsdóttir, Birna; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Thorgeirsson, Gudmundur; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Holm, Hilma; Stefansson, Kari (American Medical Association (AMA), 2020-01-01)
    Importance: Genetic studies have evaluated the influence of blood lipid levels on the risk of coronary artery disease (CAD), but less is known about how they are associated with the extent of coronary atherosclerosis. Objective: To estimate the ...
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    Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions 
    Teitsdóttir, Unnur Diljá; Jónsdóttir, María K.; Lund, Sigrún H.; Darreh-Shori, Taher; Snædal, Jón; Petersen, Pétur H. (Springer Science and Business Media LLC, 2020-08-04)
    Background: Neuroinflammation has gained increasing attention as a potential contributing factor in the onset and progression of Alzheimer's disease (AD). The objective of this study was to examine the association of selected cerebrospinal fluid (CSF) ...
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    The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study 
    Abd ElHafeez, Samar; Noordzij, Marlies; Kramer, Anneke; Bell, Samira; Savoye, Emilie; Abad Diez, José Maria; Lundgren, Torbjörn; Reisæter, Anna Varberg; Kerschbaum, Julia; Santiuste de Pablos, Carmen; Ortiz, Fernanda; Collart, Frederic; Pálsson, Runólfur; Arici, Mustafa; Heaf, James G.; Massy, Ziad A.; Jager, Kitty J. (2020-10-06)
    In this study we aimed to compare patient and graft survival of kidney transplant recipients who received a kidney from a living-related donor (LRD) or living-unrelated donor (LUD). Adult patients in the ERA-EDTA Registry who received their first kidney ...
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    Association of low-frequency and rare coding variants with information processing speed 
    Bressler, Jan; Davies, Gail; Smith, Albert Vernon; Saba, Yasaman; Bis, Joshua C.; Jian, Xueqiu; Hayward, Caroline; Yanek, Lisa; Smith, Jennifer A.; Mirza, Saira S.; Wang, Ruiqi; Adams, Hieab H.H.; Becker, Diane; Boerwinkle, Eric; Campbell, Archie; Cox, Simon R.; Eiríksdóttir, Guðný; Fawns-Ritchie, Chloe; Gottesman, Rebecca F.; Grove, Megan L.; Guo, Xiuqing; Hofer, Edith; Kardia, Sharon L.R.; Knol, Maria J.; Koini, Marisa; Lopez, Oscar L.; Marioni, Riccardo E.; Nyquist, Paul; Pattie, Alison; Polasek, Ozren; Porteous, David J.; Rudan, Igor; Satizabal, Claudia L.; Schmidt, Helena; Schmidt, Reinhold; Sidney, Stephen; Simino, Jeannette; Smith, Blair H.; Turner, Stephen T.; van der Lee, Sven J.; Ware, Erin B.; Whitmer, Rachel A.; Yaffe, Kristine; Yang, Qiong; Zhao, Wei; Guðnason, Vilmundur G.; Launer, Lenore J.; Fitzpatrick, Annette L.; Psaty, Bruce M.; Fornage, Myriam; Arfan Ikram, M.; van Duijn, Cornelia M.; Seshadri, Sudha; Mosley, Thomas H.; Deary, Ian J. (2021-12-04)
    Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare ...
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    Association of Maternal Autoimmune Diseases with Risk of Mental Disorders in Offspring in Denmark 
    He, Hua; Yu, Yongfu; Liew, Zeyan; Gissler, Mika; László, Krisztina D.; Valdimarsdóttir, Unnur Anna; Zhang, Jun; Li, Fei; Li, Jiong (2022-04-01)
    Importance: Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring during childhood, but little is known about how maternal autoimmune diseases during pregnancy are associated with mental ...
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    Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. 
    Jakubowska, A; Rozkrut, D; Antoniou, A; Hamann, U; Scott, R J; McGuffog, L; Healy, S; Sinilnikova, O M; Rennert, G; Lejbkowicz, F; Flugelman, A; Andrulis, I L; Glendon, G; Ozcelik, H; Thomassen, M; Paligo, M; Aretini, P; Kantala, J; Aroer, B; von Wachenfeldt, A; Liljegren, A; Loman, N; Herbst, K; Kristoffersson, U; Rosenquist, R; Karlsson, P; Stenmark-Askmalm, M; Melin, B; Nathanson, K L; Domchek, S M; Byrski, T; Huzarski, T; Gronwald, J; Menkiszak, J; Cybulski, C; Serrano, P; Osorio, A; Cajal, T R; Tsitlaidou, M; Benítez, J; Gilbert, M; Rookus, M; Aalfs, C M; Kluijt, I; Boessenkool-Pape, J L; Meijers-Heijboer, H E J; Oosterwijk, J C; van Asperen, C J; Blok, M J; Nelen, M R; van den Ouweland, A M W; Seynaeve, C; van der Luijt, R B; Devilee, P; Easton, D F; Peock, S; Frost, D; Platte, R; Ellis, S D; Fineberg, E; Evans, D G; Lalloo, F; Eeles, R; Jacobs, C; Adlard, J; Davidson, R; Eccles, D; Cole, T; Cook, J; Godwin, A; Bove, B; Stoppa-Lyonnet, D; Caux-Moncoutier, V; Belotti, M; Tirapo, C; Mazoyer, S; Barjhoux, L; Boutry-Kryza, N; Pujol, P; Coupier, I; Peyrat, J-P; Vennin, P; Muller, D; Fricker, J-P; Venat-Bouvet, L; Jóhannsson, Óskar Þór; Isaacs, C; Schmutzler, R; Wappenschmidt, B; Meindl, A; Arnold, N; Varon-Mateeva, R; Niederacher, D; Sutter, C; Deissler, H; Preisler-Adams, S; Simard, J; Soucy, P; Durocher, F; Chenevix-Trench, G; Beesley, J; Chen, X; Rebbeck, T; Couch, F; Wang, X; Lindor, N; Fredericksen, Z; Pankratz, V S; Peterlongo, P; Bonanni, B; Fortuzzi, S; Peissel, B; Szabo, C; Mai, P L; Loud, J T; Lubinski, J (2012-06-05)
    The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), ...
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    Association of Prenatal Exposure to Antiseizure Medication with Risk of Autism and Intellectual Disability 
    Bjørk, Marte Helene; Zoega, Helga; Leinonen, Maarit K.; Cohen, Jacqueline M.; Dreier, Julie Werenberg; Furu, Kari; Gilhus, Nils Erik; Gissler, Mika; Hálfdánarson, Óskar; Igland, Jannicke; Sun, Yuelian; Tomson, Torbjörn; Alvestad, Silje; Christensen, Jakob (2022-07-01)
    Importance: Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to AMSs is uncertain. Objective: To determine whether children exposed prenatally ...
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    Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study 
    BOLD Collaborative Research Group (2023-01)
    BACKGROUND: Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study. METHODS: ...
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    Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 
    Spiliopoulou, Athina; Colombo, Marco; Plant, Darren; Nair, Nisha; Cui, Jing; Coenen, Marieke J.H.; Ikari, Katsunori; Yamanaka, Hisashi; Saevarsdottir, Saedis; Padyukov, Leonid; Bridges, S. Louis; Kimberly, Robert P.; Okada, Yukinori; Van Riel, Piet L.C.M.; Wolbink, Gertjan; Van Der Horst-Bruinsma, Irene E.; De Vries, Niek; Tak, Paul P.; Ohmura, Koichiro; Canhão, Helena; Guchelaar, Henk Jan; Huizinga, Tom W.J.; Criswell, Lindsey A.; Raychaudhuri, Soumya; Weinblatt, Michael E.; Wilson, Anthony G.; Mariette, Xavier; Isaacs, John D.; Morgan, Ann W.; Pitzalis, Costantino; Barton, Anne; Mckeigue, Paul (2019-08-01)
    Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these ...
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    The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life : results from the Burden of Obstructive Lung Disease (BOLD) study 
    Knox-Brown, Ben; Patel, Jaymini; Potts, James; Ahmed, Rana; Aquart-Stewart, Althea; Barbara, Cristina; Buist, A. Sonia; Cherkaski, Hamid Hacene; Denguezli, Meriam; Elbiaze, Mohammed; Erhabor, Gregory E.; Franssen, Frits M.E.; Al Ghobain, Mohammed; Gíslason, Þórarinn; Janson, Christer; Kocabaş, Ali; Mannino, David; Marks, Guy; Mortimer, Kevin; Nafees, Asaad Ahmed; Obaseki, Daniel; Paraguas, Stefanni Nonna M.; Loh, Li Cher; Rashid, Abdul; Salvi, Sundeep; Seemungal, Terence; Studnicka, Michael; Tan, Wan C.; Wouters, Emiel F.M.; Abozid, Hazim; Mueller, Alexander; Burney, Peter; Amaral, Andre F.S. (2023-05-23)
    Background: Spirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown. Methods: Using data from the ...
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    Association of stress-related disorders with subsequent risk of all-cause and cause-specific mortality : A population-based and sibling-controlled cohort study 
    Tian, Fan; Shen, Qing; Hu, Yihan; Ye, Weimin; Valdimarsdóttir, Unnur A.; Song, Huan; Fang, Fang (2022-07)
    Background: Prior research provides suggestive evidence on an association between stress-related disorders and mortality. No previous study has however addressed the role of familial confounding on such association. Methods: We conducted a nationwide ...
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    Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations 
    Daya, Michelle; Bjarnadóttir, Hrafnhildur (Springer Science and Business Media LLC, 2019-02-20)
    Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true ...
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    Associations between antimicrobial susceptibility/resistance of Neisseria gonorrhoeae isolates in European Union/European Economic Area and patients’ gender, sexual orientation and anatomical site of infection, 2009–2016 
    on behalf of The Euro-GASP Network (2021-03-18)
    BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, nationally and internationally, is a serious threat to the management and control of gonorrhoea. Limited and conflicting data regarding the epidemiological ...