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The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study

The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study


Title: The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study
Author: Abd ElHafeez, Samar
Noordzij, Marlies
Kramer, Anneke
Bell, Samira
Savoye, Emilie
Abad Diez, José Maria
Lundgren, Torbjörn
Reisæter, Anna Varberg
Kerschbaum, Julia
Santiuste de Pablos, Carmen
... 7 more authors Show all authors
Date: 2021-01
Language: English
Scope: 11
University/Institute: Landspitali - The National University Hospital of Iceland
Department: Office of Division of Clinical Services I
Faculty of Medicine
Series: Transplant International; 34(1)
ISSN: 0934-0874
DOI: https://doi.org/10.1111/tri.13759
Subject: Líffæragjafir; Nýru; Lifun (heilbrigðismál); Lífslíkur; donor source; graft survival; kidney transplantation; living donation; patient survival; Transplantation
URI: https://hdl.handle.net/20.500.11815/2740

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Citation:

Abd ElHafeez , S , Noordzij , M , Kramer , A , Bell , S , Savoye , E , Abad Diez , J M , Lundgren , T , Reisæter , A V , Kerschbaum , J , Santiuste de Pablos , C , Ortiz , F , Collart , F , Pálsson , R , Arici , M , Heaf , J G , Massy , Z A & Jager , K J 2021 , ' The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study ' , Transplant International , vol. 34 , no. 1 , pp. 76-86 . https://doi.org/10.1111/tri.13759

Abstract:

In this study we aimed to compare patient and graft survival of kidney transplant recipients who received a kidney from a living-related donor (LRD) or living-unrelated donor (LUD). Adult patients in the ERA-EDTA Registry who received their first kidney transplant in 1998–2017 were included. Ten-year patient and graft survival were compared between LRD and LUD transplants using Cox regression analysis. In total, 14 370 patients received a kidney from a living donor. Of those, 9212 (64.1%) grafts were from a LRD, 5063 (35.2%) from a LUD and for 95 (0.7%), the donor type was unknown. Unadjusted five-year risks of death and graft failure (including death as event) were lower for LRD transplants than for LUD grafts: 4.2% (95% confidence interval [CI]: 3.7–4.6) and 10.8% (95% CI: 10.1–11.5) versus 6.5% (95% CI: 5.7–7.4) and 12.2% (95% CI: 11.2–13.3), respectively. However, after adjusting for potential confounders, associations disappeared with hazard ratios of 0.99 (95% CI: 0.87–1.13) for patient survival and 1.03 (95% CI: 0.94–1.14) for graft survival. Unadjusted risk of death-censored graft failure was similar, but after adjustment, it was higher for LUD transplants (1.19; 95% CI: 1.04–1.35). In conclusion, patient and graft survival of LRD and LUD kidney transplant recipients was similar, whereas death-censored graft failure was higher in LUD. These findings confirm the importance of both living kidney donor types.

Description:

The ERA‐EDTA Registry is funded by the European Renal Association‐European Dialysis and Transplant Association (ERA‐EDTA). This article was written by S. Abd ElHafeez, M. Noordzij, A. Kramer, S. Bell, E. Savoye, J.M. Abad Diez, T. Lundgren, A.V. Reisæter, J. Kerschbaum, C. Santiuste de Pablos, F. Ortiz, F. Collart, R. Palsson, M. Arici, J.G. Heaf, Z.A. Massy and K.J. Jager on behalf of the ERA‐EDTA Registry which is an official body of the ERA‐EDTA (European Renal Association – European Dialysis and Transplant Association). Publisher Copyright: © 2020 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT

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