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The Effects of Light Therapy on Cognitive Function and Stress in Women With Breast Cancer Before Systemic Treatment
(2025-11) Aspelund, Snaefridur Gudmundsdottir; Halldorsdottir, Thorhildur; Agustsson, Gudjon; Tobin, Hannah Ros Sigurdardottir; Wu, Lisa M.; Amidi, Ali; Johannsdottir, Kamilla R.; Lutgendorf, Susan K.; Telles, Rachel; Daly, Huldis Franksdottir; Sigurdardottir, Kristin; Figueiro, Mariana G.; Redd, William H.; Valdimarsdottir, Heiddis B.; Baldursdottir, Birna; Department of Psychology
Background: Cancer-related cognitive impairment (CRCI), for example, impairments in reaction time, processing speed, memory and executive function, may be associated with breast cancer (BC) surgery which can disrupt biological and psychological stress markers. Evidence suggests that light therapy may ameliorate cognitive impairment and stress. In this double-blind, randomized controlled trial, we investigated the efficacy of light therapy on mitigating the impact of BC surgery on CRCI in a national Icelandic cohort of women with BC. Methods: Participants were randomly allocated to receive circadian-effective blue light (BL, N = 60) or circadian-ineffective dim light (DL, N = 57) for 4 weeks after surgery. The primary outcome was overall cognitive performance (assessed via global composite score), and secondary outcomes were specific cognitive domains, cognitive complaints, psychological (depressive symptoms, overall cancer-related stress and its symptoms: hyperarousal, avoidance, and intrusive thoughts) and biological (cortisol and α-amylase) stress markers. Linear regression and path analyses within structural equation modeling frameworks were conducted, adjusted for baseline cognitive performance, age, education, subsequent cancer treatment, cancer stage, and treatment credibility. Results: No group differences were found in overall cognitive performance or in specific cognitive domains, except for a non-significant trend for faster reaction times in the BL group (p < 0.11). Additionally, the BL group reported significantly fewer cognitive complaints compared with the DL group (p < 0.05), as well as a non-significant trend for less intrusive thoughts (p < 0.11). No group differences were observed in the biological stress markers. Conclusion: Overall, these findings suggest that light therapy may help mitigate the adverse effects associated with BC surgery on CRCI and intrusive thoughts, although further research is warranted. Trial Registration: NCT04418856.
Verk
Multimodality in Media Retrieval
(Association for Computing Machinery, Inc, 2024-06-07) Pegia, Maria Eirini; Department of Computer Science
The quest for retrieving relevant media for a given query is well-studied and has various applications. Modern publicly available media collections provide diverse modalities of the same objects, which can enhance search. Our research delves into enhancing media retrieval by effectively representing and querying multimodal data. In the retrieval methods’ ranking procedure, we examine efficiency through techniques like approximate nearest neighbor (ANN) indexing and high-performance computing (HPC). Our method, MuseHash, is proposed for single media object retrieval and is applied to images and 3D objects, outperforming existing methods on diverse datasets. Moreover, it significantly reduces execution times with ANN and HPC. Future plans include considering multimodality in the video retrieval domain.
Verk
3DMSE : An Interactive 3D Media Search Engine
(Association for Computing Machinery, Inc, 2024-06-07) Pegia, Maria Eirini; Georgalis, Dimitris; Pantelidis, Nick; Jónsson, Björn Þór; Moumtzidou, Anastasia; Diplaris, Sotiris; Gialampoukidis, Ilias; Vrochidis, Stefanos; Kompatsiaris, Ioannis; Department of Computer Science
We present the 3D Media Search Engine (3DMSE), which is designed to facilitate the exploration and retrieval of 3D models and images. 3DMSE incorporates unimodal, cross-modal and multimodal retrieval, using any combinations of mesh, point-cloud and multi-image representations. The 3DMSE system is built on the recently proposed MuseHash approach for multimodal representation, and offers a user-friendly web interface that enables formulating queries, presenting search results, and visualising 3D information in an accessible manner.
Verk
Time after time : failure to identify and support females with ADHD – a Swedish population register study
(2024-06) Skoglund, Charlotte; Sundström Poromaa, Inger; Leksell, Daniel; Ekholm Selling, Katarina; Cars, Thomas; Giacobini, Maibritt; Young, Susan; Kopp Kallner, Helena
Background: Attention deficit hyperactivity disorder (ADHD) is associated with risk taking and negative health-related outcomes across the lifespan. Due to delay in referral and diagnostics, young females with ADHD may not be identified, nor appropriately supported by adequate interventions. Methods: A total of 85,330 individuals with ADHD, all of whom were residents in Stockholm County between January 01, 2011, and December 31, 2021, were included as participants in this population-based, cross-sectional cohort study. Population controls (n = 426,626) were matched by age, sex, and socioeconomic status (SES). Data was obtained from Regional Healthcare Data Warehouse of Region Stockholm (VAL) in Stockholm County. Exposure was ADHD-index, defined as the first record of either ICD-10 F90 diagnosis and/or ATC-code for stimulant or non-stimulant ADHD-medication during the study period. Primary outcome was age at ADHD-index. Secondary outcome measures were psychiatric comorbidity, pharmacological treatment, and health care utilization, prior to and after ADHD-index. Results: Females were older at ADHD-index (23.5 years, SD 13.8) compared to males (19.6 years, SD 13.9, 95% CI of difference 3.74–4.11). Overall, females with ADHD showed higher rates of psychiatric comorbidity, pharmacological treatment, and health care utilization, compared to males with ADHD and female controls. Conclusions: Females with ADHD receive diagnosis and treatment for ADHD approximately 4 years later than males. They have a higher burden of comorbid psychiatric conditions and health care utilization, compared to males with ADHD and female controls, both prior to and after ADHD-index. To prevent long-term adverse consequences for females with ADHD, methods, and tools for early diagnosis and treatments that mitigate personal suffering and societal burden are warranted.
Verk
Nocturnal oxygen resaturation parameters are associated with cardiorespiratory comorbidities
(2024-06) Howarth, Timothy P.; Sillanmäki, Saara; Karhu, Tuomas; Rissanen, Marika; Islind, Anna Sigridur; Hrubos-Strøm, Harald; de Chazal, Philip; Huovila, Juuso; Kainulainen, Samu; Leppänen, Timo; Department of Computer Science
Background: There are strong associations between oxygen desaturations and cardiovascular outcomes. Additionally, oxygen resaturation rates are linked to excessive daytime sleepiness independent of oxygen desaturation severity. No studies have yet looked at the independent effects of comorbidities or medications on resaturation parameters. Methods: The Sleep Heart Health Study data was utilised to derive oxygen saturation parameters from 5804 participants. Participants with a history of comorbidities or medication usage were compared against healthy participants with no comorbidity/medication history. Results: 4293 participants (50.4% female, median age 64 years) were included in the analysis. Females recorded significantly faster resaturation rates (mean 0.61%/s) than males (mean 0.57%/s, p < 0.001), regardless of comorbidities. After adjusting for demographics, sleep parameters, and desaturation parameters, resaturation rate was reduced with hypertension (-0.09 (95% CI -0.16, -0.03)), myocardial infarction (-0.13 (95% CI -0.21, -0.04)) and heart failure (-0.19 (95% CI -0.33, -0.05)), or when using anti-hypertensives (-0.10 (95% CI -0.17, -0.03)), mental health medications (-0.18 (95% CI -0.27, -0.08)) or anticoagulants (-0.41 (95% CI -0.56, -0.26)). Desaturation to Resaturation ratio for duration was decreased with mental health (-0.21 (95% CI -0.34, -0.08)) or diabetic medications (-0.24 (95% CI -0.41, -0.07)), and desaturation to resaturation ratio for area decreased with heart failure (-0.25 (95% CI -0.42, -0.08)). Conclusions: Comorbidities and medications significantly affect nocturnal resaturation parameters, independent of desaturation parameters. However, the causal relationship remains unclear. Further research can enhance our knowledge and develop more precise and safer interventions for individuals affected by certain comorbidities.

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