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Deep Learning Techniques to Diagnose Lung Cancer
(2022-11) Wang, Lulu; Department of Engineering
Medical imaging tools are essential in early-stage lung cancer diagnostics and the monitoring of lung cancer during treatment. Various medical imaging modalities, such as chest X-ray, magnetic resonance imaging, positron emission tomography, computed tomography, and molecular imaging techniques, have been extensively studied for lung cancer detection. These techniques have some limitations, including not classifying cancer images automatically, which is unsuitable for patients with other pathologies. It is urgently necessary to develop a sensitive and accurate approach to the early diagnosis of lung cancer. Deep learning is one of the fastest-growing topics in medical imaging, with rapidly emerging applications spanning medical image-based and textural data modalities. With the help of deep learning-based medical imaging tools, clinicians can detect and classify lung nodules more accurately and quickly. This paper presents the recent development of deep learning-based imaging techniques for early lung cancer detection.
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Artificial intelligence techniques in liver cancer
(2024) Wang, Lulu; Fatemi, Mostafa; Alizad, Azra; Department of Engineering
Hepatocellular Carcinoma (HCC), the most common primary liver cancer, is a significant contributor to worldwide cancer-related deaths. Various medical imaging techniques, including computed tomography, magnetic resonance imaging, and ultrasound, play a crucial role in accurately evaluating HCC and formulating effective treatment plans. Artificial Intelligence (AI) technologies have demonstrated potential in supporting physicians by providing more accurate and consistent medical diagnoses. Recent advancements have led to the development of AI-based multi-modal prediction systems. These systems integrate medical imaging with other modalities, such as electronic health record reports and clinical parameters, to enhance the accuracy of predicting biological characteristics and prognosis, including those associated with HCC. These multi-modal prediction systems pave the way for predicting the response to transarterial chemoembolization and microvascular invasion treatments and can assist clinicians in identifying the optimal patients with HCC who could benefit from interventional therapy. This paper provides an overview of the latest AI-based medical imaging models developed for diagnosing and predicting HCC. It also explores the challenges and potential future directions related to the clinical application of AI techniques.
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Acoustic radiation force based ultrasound elasticity imaging for biomedical applications
(2018-07-12) Wang, Lulu; Department of Engineering
Pathological changes in biological tissue are related to the changes in mechanical properties of biological tissue. Conventional medical screening tools such as ultrasound, magnetic resonance imaging or computed tomography have failed to produce the elastic properties of biological tissues directly. Ultrasound elasticity imaging (UEI) has been proposed as a promising imaging tool to map the elastic parameters of soft tissues for the clinical diagnosis of various diseases include prostate, liver, breast, and thyroid gland. Existing UEI-based approaches can be classified into three groups: internal physiologic excitation, external excitation, and acoustic radiation force (ARF) excitation methods. Among these methods, ARF has become one of the most popular techniques for the clinical diagnosis and treatment of disease. This paper provides comprehensive information on the recently developed ARF-based UEI techniques and instruments for biomedical applications. The mechanical properties of soft tissue, ARF and displacement estimation methods, working principle and implementation instruments for each ARF-based UEI method are discussed.
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Trawl-door shape optimization by space-mapping-corrected CFD models and kriging surrogates
(2016) Jonsson, Ingi M.; Leifsson, Leifur; Koziel, Slawomir; Tesfahunegn, Yonatan A.; Bekasiewicz, Adrian; Department of Engineering
Trawl-doors are a large part of the fluid flow resistance of trawlers fishing gear and has considerable effect on the fuel consumption. A key factor in reducing that consumption is by implementing computational models in the design process. This study presents a robust two dimensional computational fluid dynamics models that is able to capture the nonlinear flow past multi-element hydrofoils. Efficient optimization algorithms are applied to the design of trawl-doors using problem formulation that captures true characteristics of the design space where lift-to-drag ratio is maximized. Four design variables are used in the optimization process to control the fluid flow angle of attack, as well as position and orientation of a leading-edge slat. The optimization process involves both multi-point space mapping, and mixed modeling techniques that utilize space mapping to create a physics-based surrogate model. The results demonstrate that lift-to-drag maximization is more appropriate than lift-constraint drag minimization in this case and that local search using multi-point space mapping can yield satisfactory design at low computational cost. By using global search with mixed modeling a solution with higher quality is obtained, but at a higher computational cost than local search.
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Surrogate-based airfoil design with space mapping and adjoint sensitivity
(2015) Tesfahunegn, Yonatan A.; Koziel, Slawomir; Leifsson, Leifur; Bekasiewicz, Adrian; Department of Engineering
This paper presents a space mapping algorithm for airfoil shape optimization enhanced with adjoint sensitivities. The surrogate-based algorithm utilizes low-cost derivative information obtained through adjoint sensitivities to improve the space mapping matching between a high-fidelity airfoil model, evaluated through expensive CFD simulations, and its fast surrogate. Here, the airfoil surrogate model is constructed though low-fidelity CFD simulations. As a result, the design process can be performed at a low computational cost in terms of the number of high-fidelity CFD simulations. The adjoint sensitivities are also exploited to speed up the surrogate optimization process. Our method is applied to a constrained drag minimization problem in two-dimensional inviscid transonic flow. The problem is solved for several low-fidelity model termination criteria. The results show that when compared with direct gradient-based optimization with adjoint sensitivities, the proposed approach requires 49-78% less computational cost while still obtaining a comparable airfoil design.

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