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Functional Brain Dysconnectivity in Parkinson's Disease : A 5-Year Longitudinal Study
(2022-07) Yassine, Sahar; Gschwandtner, Ute; Auffret, Manon; Achard, Sophie; Verin, Marc; Fuhr, Peter; Hassan, Mahmoud
Background: Tracking longitudinal functional brain dysconnectivity in Parkinson's disease (PD) is a key element to decoding the underlying physiopathology and understanding PD progression. Objectives: The objectives of this follow-up study were to explore, for the first time, the longitudinal changes in the functional brain networks of PD patients over 5 years and to associate them with their cognitive performance and the lateralization of motor symptoms. Methods: We used a 5-year longitudinal cohort of PD patients (n = 35) who completed motor and non-motor assessments and sequent resting state (RS) high-density electroencephalography (HD-EEG) recordings at three timepoints: baseline (BL), 3 years follow-up (3YFU) and 5 years follow-up (5YFU). We assessed disruptions in frequency-dependent functional networks over the course of the disease and explored their relation to clinical symptomatology. Results: In contrast with HC (n = 32), PD patients showed a gradual connectivity impairment in α2 (10-13 Hz) and β (13–30 Hz) frequency bands. The deterioration in the global cognitive assessment was strongly correlated with the disconnected networks. These disconnected networks were also associated with the lateralization of motor symptoms, revealing a dominance of the right hemisphere in terms of impaired connections in the left-affected PD patients in contrast to dominance of the left hemisphere in the right-affected PD patients. Conclusions: Taken together, our findings suggest that with disease progression, dysconnectivity in the brain networks in PD can reflect the deterioration of global cognitive deficits and the lateralization of motor symptoms. RS HD-EEG may be an early biomarker of PD motor and non-motor progression.
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Anxious and status signaling : Examining the link between attachment style and status consumption and the mediating role of materialistic values
(2022-05) Gasiorowska, Agata; Folwarczny, Michał; Otterbring, Tobias; Department of Business and Economics
Attachment theory has recently been recognized as a potentially fruitful avenue for studying consumer behavior. However, few studies have examined the relationship between attachment styles and consumer preferences. Based on literature suggesting that individuals with an anxious attachment style have a particularly strong need for attention, we conducted two studies with a total sample of over 2000 participants, which tested and found that anxiously attached consumers displayed a higher propensity to purchase status-signaling goods than their counterparts with secure attachment styles. This effect was mediated by materialistic values, such that participants with an anxious attachment style reported the highest materialistic values. Additionally, we found mixed evidence for the relationship between an avoidant attachment style, materialism, and status consumption. Together, these findings highlight the importance of attachment theory in the study of status consumption and offer potential implications for research on social status and related research areas.
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Faster Exploration of Some Temporal Graphs
(Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing, 2022-04-01) Adamson, Duncan; Gusev, Vladimir V.; Malyshev, Dmitriy; Zamaraev, Viktor; Aspnes, James; Michail, Othon
A temporal graph G = (G1, G2,..., GT ) is a graph represented by a sequence of T graphs over a common set of vertices, such that at the ith time step only the edge set Ei is active. The temporal graph exploration problem asks for a shortest temporal walk on some temporal graph visiting every vertex. We show that temporal graphs with n vertices can be explored in O(kn1.5 log n) days if the underlying graph has treewidth k and in O(n1.75 log n) days if the underlying graph is planar. Furthermore, we show that any temporal graph whose underlying graph is a cycle with k chords can be explored in at most 6kn days. Finally, we demonstrate that there are temporal realisations of sub cubic planar graphs that cannot be explored faster than in Ω(n log n) days. All these improve best known results in the literature.
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Improving adherence to a web-based cognitive-behavioural therapy program for social anxiety with group sessions : A randomised control trial
(2022-04) Sigurðardóttir, Signý; Helgadóttir, Fjóla Dögg; Menzies, Rachel E.; Sighvatsson, Magnús Blöndahl; Menzies, Ross G.
Individuals with social anxiety disorder (SAD) commonly receive non-evidence based, ineffective treatments. Cognitive behaviour therapy (CBT) has been demonstrated to be the gold standard treatment for treating SAD. Scalable web-based CBT programs ensure evidence-based treatment procedures, but low treatment adherence remains problematic. This study aimed to test whether adding group sessions to a fully automated web-based CBT program, Overcome Social Anxiety (OSA), would increase treatment adherence. A total of 69 participants were provided access to a web-based program, and randomly allocated to three conditions: 1) An experimental condition involving an addition of three online group psychoeducation sessions; 2) a placebo condition involving an addition of three online progressive muscle relaxation (PMR) group sessions, or 3) a control condition where participants did not receive group sessions. Adherence was operationalised as number of OSA modules completed. Treatment adherence significantly differed between the conditions. On average, participants assigned to the placebo condition completed significantly more of the program compared to those in the control condition. Further, all conditions produced a significant improvement in BFNE and QOLS. No significant difference in treatment efficacy was found between groups on the SIAS, BFNE or QOLS. The current results indicate PMR can improve treatment adherence for scalable social anxiety interventions.
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Pharmacological and non-pharmacological interventions for adults with ADHD : Protocol for a systematic review and network meta-analysis
(2022-03-11) Cortese, Samuele; Del Giovane, Cinzia; Chamberlain, Samuel; Philipsen, Alexandra; Young, Susan; Bilbow, Andrea; Cipriani, Andrea
Introduction It is unclear how pharmacological and non-pharmacological interventions compare with each other in terms of efficacy and tolerability for core symptoms and additional problems in adults with attention-deficit/hyperactivity disorder (ADHD). We aim to conduct the first network meta-analysis (NMA) comparing pharmacological and non-pharmacological interventions (or their combinations) in adults with ADHD. Methods and analysis We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for NMAs. We will search a broad set of electronic databases/registries and contact drug companies and experts in the field to retrieve published and unpublished randomised controlled trials (RCTs) (parallel or cross-over) of medications (either licensed or unlicensed) and any non-pharmacological intervention in adults (≥18 years) with ADHD. Primary outcomes will be: (1) change in severity of ADHD core symptoms, and (2) acceptability (all-cause discontinuation). Secondary outcomes will include tolerability (drop-out due to side effects) and change in the severity of emotional dysregulation, executive dysfunctions and quality of life. The risk of bias in each individual RCT included in the NMA will be assessed using the Cochrane Risk of Bias tool-version 2. We will evaluate the transitivity assumption comparing the distribution of possible effect modifiers across treatment comparisons. We will perform Bayesian NMA for each outcome with random-effects model in OpenBUGS. Pooled estimates of NMA will be obtained using the Markov Chains Monte Carlo method. We will judge the credibility in the evidence derived from the NMA using the CINeMA tool (which includes assessment of publication bias). We will conduct a series of sensitivity analyses to assess the robustness of the findings. Ethics and dissemination As this is the protocol for an aggregate-data level NMA, ethical approval will not be required. Results will be disseminated at national/international conferences and in peer-reviewed journals. PROSPERO registration number CRD42021265576.

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