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An electroencephalography connectome predictive model of major depressive disorder severity
(2022-12) Kabbara, Aya; Robert, Gabriel; Khalil, Mohamad; Verin, Marc; Benquet, Pascal; Hassan, Mahmoud
Emerging evidence showed that major depressive disorder (MDD) is associated with disruptions of brain structural and functional networks, rather than impairment of isolated brain region. Thus, connectome-based models capable of predicting the depression severity at the individual level can be clinically useful. Here, we applied a machine-learning approach to predict the severity of depression using resting-state networks derived from source-reconstructed Electroencephalography (EEG) signals. Using regression models and three independent EEG datasets (N = 328), we tested whether resting state functional connectivity could predict individual depression score. On the first dataset, results showed that individuals scores could be reasonably predicted (r = 0.6, p = 4 × 10–18) using intrinsic functional connectivity in the EEG alpha band (8–13 Hz). In particular, the brain regions which contributed the most to the predictive network belong to the default mode network. We further tested the predictive potential of the established model by conducting two external validations on (N1 = 53, N2 = 154). Results showed statistically significant correlations between the predicted and the measured depression scale scores (r1 = 0.52, r2 = 0.44, p < 0.001). These findings lay the foundation for developing a generalizable and scientifically interpretable EEG network-based markers that can ultimately support clinicians in a biologically-based characterization of MDD.
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A hybrid numerical/machine learning model development to improve the bimetal performance in the electric circuit breakers
(2022-12) Mallah, Abdul Rahman; Aljuraid, Nawaf; Alawi, Omer A.; Yaseen, Zaher Mundher; Singh, Kamaljeet; Ataki, Adel; Department of Engineering
Bimetals are widely used as a thermal tripping mechanism inside the miniature circuit breakers (MCBs) products when an overload current passes through the circuit for a certain period. Experimental, numerical, and, recently artificial intelligence methods are widely used in designing electric components. However, developing the bimetal for MCB products somewhat differs from developing other conductor items since they are strongly related to the electrical, mechanical, and thermal performance of the MCB. The conventional experimental and numerical approaches are time-consuming processes that cannot be easily utilized in optimizing the product's performance within the development lead time. In this study, a simple, fast, robust, and accurate novel methodology has been introduced to predict the temperature rise of the bimetal and other related performance characteristics. The numerical model has been built on the time-based finite difference method to frame the theoretical thermal model of the bimetal. Then, the numerical model has been consolidated by the machine learning (ML) model to take advantage of the experiments to provide an accurate, fast and reliable model finally. The novel model agrees well with the experimental tests, where the maximum error does not exceed 8%. The model has been used to redesign the bimetal of a 32 A MCB product and significantly reduce the maximum temperature by 24 °C. The novel model is promising since it considerably reduces the required design time, provides accurate predictions, and helps to optimize the performance of the circuit breaker products.
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The dynamic evolution of the Lahendong geothermal system in North-Sulawesi, Indonesia
(2022-11) Suherlina, Lily; Newson, Juliet; Kamah, Yustin; Brehme, Maren
This study uses an integrated approach to characterize the dynamic evolution of the power-producing high-enthalpy geothermal system of Lahendong, North-Sulawesi, Indonesia. Lahendong has two primary reservoirs, the southern and the northern, which have been utilised for electricity production for more than twenty years. The main focus of this study is the characterisation of heat and mass flows in the system with respect to geological structures and permeability distribution. Also, it delineates how the geothermal system has evolved and the spatial variation of the response resulting from prolonged utilization of the reservoirs. This research implemented geological structure analysis on recent surface fault mapping and pre-existing fault studies from literature. Further, the study analysed well data comprising well pressure, enthalpy, drilling program reviews and tracer tests. Hydrochemical investigation compiled new and old surface and subsurface hydrochemical evolution in both the temporal and spatial domain. The results confirm several fault trends in the study area: NE-SW and NW-SE are the major striking directions, while E-W and N-S are less dominant. The most apparent trends are NE-SW striking strike-slip faults, NW-SE thrust faults and N-S and E-W striking normal faults. The faults compartmentalize the reservoir. A comparison of the southern and the northern reservoir shows that the southern one is more controlled by faults; both reservoirs rely on fractures as permeability provider and are controlled by shallow hydrogeology, as derived from the integrated analysis of transient well data. Geochemical analysis shows that the reservoir fluids have generally a higher eelectrical conductivity and are closer to fluid-rock equilibrium, probably due to boiling, compared to spring waters. Spring waters have generally become more acidic, which is an expected result of reservoir boiling and increased steam input to near-surface waters. The spatial distribution of changes shows a permeability evolution over time and also the role of structural permeability in response to changing reservoir conditions. Observing and recording reservoir data is highly important to understand the reservoir response to production and ensure the long-term sustainability of the system. Additionally, the data is critical for making a major difference in the reservoir management strategy.
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Crustal response to inflation imaged by mapping of subsurface faults, slip directions, and stress changes during the 1993–1998 unrest in Hengill, SW-Iceland
(2022-11) Blanck, Hanna; Vogfjörd, Kristín S.; Geirsson, Halldór; Hjörleifsdóttir, Vala; Department of Engineering
Between 1993 and 1998, the Hengill volcanic region in southwest Iceland was subject to a significant volcano-tectonic event which caused a total of 8 cm uplift and induced >90 thousand earthquakes, most of magnitude smaller than 2 ML and a small intrusion has been proposed as its cause. In this paper, we study fault activation around the uplift center to analyze whether the Coulomb stress change induced by such an intrusion would cause the observed crustal response. The locations of a subset of 12,000 micro-earthquakes are significantly improved by a double-difference relocation algorithm and the use of cross-correlation of waveforms to refine phase arrival times. The vast majority of seismic activity is scattered, but twenty-five (25) rectangular prisms, consisting of 11 to 363 earthquakes and 200 to 3000 m long, were identified and are interpreted as faults. Most of these faults are sub-vertical (within 5° from vertical) and only two faults dip at angles of 62° and 65°, respectively. Focal mechanism analysis of individual events was applied to estimate slip direction on these faults. Simulation of the Coulomb stress changes reveals that the stress changes would have been able to induce the observed fault movement on 22 of 25 faults. Discrepancies on the remaining faults are likely caused by uncertainties in the rake directions. Our results emphasize that the seismicity caused by a volume change in the crust is controlled by the interplay between the local stress field and the induced stresses.
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What does current science tell us about the accuracy, reliability, and completeness of intoxicated witnesses? A case example of the murder of a prime minister
(2022-10-28) Hildebrand Karlén, Malin; de Bejczy, Andrea; Anckarsäter, Henrik; Guðjónsson, Gísli
Generally, the testimony of intoxicated witnesses has been considered relatively unreliable, but recent research has nuanced the knowledge base regarding these vulnerable witnesses. Purpose: To demonstrate the application of recent research findings regarding intoxicated witnesses to the statements made by a key witness to the murder of Olof Palme, Sweden's prime minister, in 1986. An additional purpose was to illustrate the use of a nuanced calculation of blood alcohol concentration (BAC) for researchers. Methods: The Palme murder has been debated since the crime was committed and no one has yet been sentenced. One of the witnesses was intoxicated and to estimate a range for his BAC at the time, a comprehensive BAC calculation was conducted in this study to illustrate important factors to consider in these types of cases. Results: Through the demonstration of the use of a nuanced BAC formula and by applying recent research results from studies on intoxicated witnesses, it was estimated that the possible BAC of the witness in the Palme-case at the time of the witnessed crime ranged between BAC = 0 to BAC = 0.13, depending on the type of alcoholic beverage consumed and whether the witness was a social or heavy drinker. This puts the witness either well within the span of maintained completeness as well as maintained accuracy rate (if considering: lowest dose and heavy drinker), or slightly exceeding this span into the BAC-range of reduced completeness but maintained accuracy rate (if considering: highest dose and social drinker). He was questioned immediately, and thereafter repeatedly, and he reported similar information throughout the interviews, which is in line with previous results on information maintenance over repeated interviews among intoxicated witnesses. Conclusion: The current case example shows how recent research on intoxicated witnesses can be applied in praxis, illustrating important factors for legal practitioners to consider when interpreting information from intoxicated witnesses. It also provides legal practitioners and researchers with an example of a structured approach to more nuanced BAC-calculations.

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