Opin vísindi

 

Nýlega bætt við

Verk
Impact of radiation dose on neurocognitive function and quality of life in long-term survivors of childhood brain tumour
(2025-09-18) Toussaint, Laura; Helligsø, Anne Sophie Lind; Muren, Ludvig Paul; Amidi, Ali; Dahlrot, Rikke Hedegaard; Henriksen, Louise Tram; Maraldo, Maja Vestmø; Nielsen, Martin Skovmos; Trip, Anouk Kirsten; Wu, Lisa Maria; Lassen-Ramshad, Yasmin; Department of Psychology
Background and purpose: Children treated with radiotherapy (RT) for a brain tumour often exhibit neurocognitive impairment and report lower quality of life (QoL) later in life. The aim of this nationwide cross-sectional cohort study was to explore the impact of RT dose to brain organs at risk (OARs) on neurocognition and QoL in long-term survivors of childhood brain tumours. Patient/material and methods: A total of 132 survivors of childhood brain tumours, diagnosed from 2001 to 2017 in Denmark, underwent neurocognitive tests and QoL questionnaires at least 5-years post-diagnosis. Neurocognitive assessments were complete and available for 86 patients (61 no-RT/25 RT), and QoL scores for 107 (79 no-RT/28 RT). Mann Whitney U-tests were used to compare scores between no-RT and RT groups. For scores impacted by RT, OAR-specific robust linear regressions were performed to evaluate RT dose effects while adjusting for potential confounders. Results: Clinically significant overall cognitive impairment was observed for 55% of the neurocognitive sub-cohort, with younger age at treatment time as a significant risk factor, while hydrocephalus status had no impact. There were no statistically significant differences on neurocognitive tests between the RT and no-RT group. However, patients treated with RT had significantly lower scores on the physical and social functioning QoL domains, with mean dose to the pituitary gland and left hippocampus, respectively, as significant predictors. Interpretation: This cross-sectional study indicates that RT dose-effects, particularly in the pituitary gland and left hippocampus, might contribute to reduced QoL in survivors of childhood brain tumours.
Verk
IDENTIFYING CURRICULUM DISRUPTIONS IN ENGINEERING EDUCATION THROUGH SERIOUS GAMING
(European Society for Engineering Education (SEFI), 2025) Waldeck, Roger; Winkens, Ann Kristin; Lemke, Clara; Leicht-Scholten, Carmen; Audunsson, Haraldur; Kangaslampi, Riikka; Langie, Greet; J�rvinen, Hannu-Matti; Nagy, Bal�zs; Department of Engineering
This workshop introduces participants to SUCRE, a serious game designed to enhance curriculum resilience in higher education by simulating crisis scenarios. While applicable to various disciplines, this session focuses on engineering curricula, identifying discipline-specific challenges and potential adaptations. Participants will engage in Step 1 of the game, analyzing trigger events and their impacts on curriculum structures. At the end of the workshop, attendees will be able to identify key triggers that may affect curricula, assess their cascading effects, and reflect on the applicability of SUCRE within their own institutions.
Verk
Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture
(2025) Clerici, Marta; Ciardulli, Maria Camilla; Lamparelli, Erwin Pavel; Lovecchio, Joseph; Giordano, Emanuele; Dale, Tina P.; Forsyth, Nicholas R.; Maffulli, Nicola; Della Porta, Giovanna
Tendon injuries significantly impact quality of life, prompting the exploration of innovative solutions beyond conventional surgery. Extracellular Vesicles (EVs) have emerged as a promising strategy to enhance tendon regeneration. In this study, human Tendon Stem/Progenitor Cells (TSPCs) were isolated from surgical biopsies and cultured in a Growth-Differentiation Factor-5-supplemented medium to promote tenogenic differentiation under static and dynamic conditions using a custom-made perfusion bioreactor. Once at 80% confluence, cells were transitioned to a serum-free medium for conditioned media collection. Ultracentrifugation revealed the presence of vesicles with a 106 particles/mL concentration and sub-200nm diameter size. Dynamic culture yielded a 3-fold increase in EV protein content compared to static culture, as confirmed by Western-blot analysis. Differences in surface marker expression were also shown by flow cytometric analysis. Data suggest that we efficiently developed a protocol for extracting EVs from human TSPCs, particularly under dynamic conditions. This approach enhances EV protein content, offering potential therapeutic benefits for tendon regeneration. However, further research is needed to fully understand the role of EVs in tendon regeneration.
Verk
Gifts for EJTM authors and readers and for PDM3 participants
(2025) Carraro, Ugo; Fanò-Illic, Giorgio; Forni, Riccardo; Maccarone, Maria Chiara; Masiero, Stefano; Department of Engineering
The summer of 2025 is approaching and the need to finalize our plans for the next few years is urgent. The next Padua Days of Muscle and Mobility Medicine (PDM3) will be held from 3 to 6 March 2026 at the Hotel Petrarca, Euganean Thermae (Padova, Italy). A preliminary flyer for 2026PDM3 is almost ready with organizers, session schedule and keynote speakers. A new Website, named Padua Muscle Days, will be soon released with all the needed information for How to Join, Registration, Accommodation, Payments and the Abstract Template for the 2026 PDM3. We hope that readers will circulate its link (www.paduamuscledays.com) among Colleagues and Friends. No doubt that 2026 PDM3 will be a great gift for all Participants. The other novelty scheduled for June 2025 is the 2024 Impact Factor that Clarivate will publish. As authors who publish in other journals, but even more as reviewers, readers could contribute to making bigger a small gift. In any case, it is a gift that has been waited for decades. Four Guest Editors have done their best to make the 35 (2) 2025 European Journal of Translational Myology and Mobility Medicine (Ejtm) a very special ssue. Indeed, it is mainly dedicated to two Thematic Sections. The first, with more works, is named Advances in Musculoskeletal and Neuromuscular Rehabilitation – Maria Chiara Maccarone & Stefano Masiero, Eds. The second is called: Generative AI for Translational Mobility Medicine, Giorgio Fanò-Illic & Riccardo Forni, Eds., and aims to attract works that use Digital Methods for Translational Mobility Medicine. We invite the members of the Ejtm editorial board and the authors of highly cited articles to follow these examples and suggest further thematic sections for the Ejtm of the next decade.
Verk
A two-phase systematic literature review on the use of serious games for sustainable environmental education
(2025) Ahmadov, Tarlan; Karimov, Ayaz; Durst, Susanne; Saarela, Mirka; Gerstlberger, Wolfgang; Wahl, Mike Franz; Karkkainen, Tommi; Department of Business and Economics
This study explores the landscape of serious games for sustainable environmental education, focusing on game types, theoretical foundations, and pedagogical approaches to provide valuable insights for educators, researchers, and policymakers. Using an umbrella literature review methodology, it examines empirical studies published between 2006 and 2023 on serious games in this field. The findings reveal a growing interest in serious games for sustainability, highlighting advancements in gaming technologies. It also identifies various game types, theoretical perspectives, and pedagogical strategies used to promote sustainability education. The study offers a comprehensive overview of the role of serious games in fostering sustainable behaviors, synthesizing key empirical studies, frameworks, and practical applications. Its insights can help educators design and implement serious games that effectively integrate diverse pedagogical and theoretical approaches, enhancing learning outcomes and raising sustainability awareness.

Flokkar í Opnum vísindum

Veldu flokk til að skoða.

Niðurstöður 1 - 9 af 9