This is the institutional repository for peer reviewed articles published in open access and doctoral dissertations by the Agricultural University of Iceland, the Iceland Academy of the Arts, the National and University Library of Iceland, Reykjavik University, the University of Akureyri, Bifröst University, Hólar University College and the University of Iceland. Open access to research results is in accordance with article 10 from the Act on public support for research / 2003 No 3 and is compliant with requirements from international and domestic research fund programs. The purpose of the Open Science repository is to make results of research conducted at Icelandic universities accessible to the public online without hindrance or charge. Deposits to the repository are permanent and are intended to ensure future access to all published scientific material of the Icelandic research community. By collecting this material together in one collection access is made simple and easy for anyone who wishes to study the considerable scientific work conducted in Iceland.

The repository is OpenAIRE / OpenAIREplus compliant and in accordance with requirements for publication of research results from projects supported by the European research programs FP7 and H2020.

The repository uses the open software DSpace.

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    Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and Controls : Data From 5 Nordic Registries 
    Provan, Sella Aarrestad; Ljung, Lotta; Kristianslund, Eirik Klami; Michelsen, Brigitte; Uhlig, Till; Jónmundsson, Þórarinn; Sexton, Joe; Guðbjörnsson, Björn; Di Giuseppe, Daniela; Hetland, Merete Lund; Reynisdóttir, Guðrún Björk; Glintborg, Bente; Relas, Heikki; Aaltonen, Kalle; Kvien, Tore Kristian; Askling, Johan (2024-10-01)
    OBJECTIVE: Interstitial lung disease (ILD) is one of the most common pulmonary manifestations of rheumatoid arthritis (RA), but its prevalence has not been investigated in psoriatic arthritis (PsA). The role of methotrexate (MTX) in ILD development ...
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    Sex differences in patterns of potentially inappropriate prescribing and adverse drug reactions in hospitalized older people : Findings from the SENATOR trial 
    O'Mahony, Denis; Cruz-Jentoft, Alfonso J; Guðmundsson, Aðalsteinn; Soiza, Roy L; Petrovic, Mirko; Cherubini, Antonio; Byrne, Stephen; Rochon, Paula (2024-07-09)
    BACKGROUND: Older women experience more adverse drug reactions (ADRs) than older men. However, the underlying basis for this sex difference is unclear. Sex (biological status) and/or gender (sociocultural constructs) influences on patterns of inappropriate ...
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    Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients 
    Cui, Yanhua; Harteveld, Femke; Ba Omar, Hajar Ali Mohammed; Yang, Yifan; Bjarnason, Ragnar Grímur; Romerius, Patrik; Sundin, Mikael; Noreń Nyström, Ulrika; Langenskiöld, Cecilia; Vogt, Hartmut; Henningsohn, Lars; Frisk, Per; Vepsäläinen, Kaisa; Petersen, Cecilia; Mitchell, Rod T.; Guo, Jingtao; Alves-Lopes, João Pedro; Jahnukainen, Kirsi; Stukenborg, Jan Bernd (2024)
    STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from ...
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    A Genotype/Phenotype Study of KDM5B-Associated Disorders Suggests a Pathogenic Effect of Dominantly Inherited Missense Variants 
    Borroto, Maria Carla; Michaud, Coralie; Hudon, Chloé; Agrawal, Pankaj B.; Agre, Katherine; Applegate, Carolyn D.; Beggs, Alan H.; Björnsson, Hans Tómas; Callewaert, Bert; Chen, Mei Jan; Curry, Cynthia; Devinsky, Orrin; Dudding-Byth, Tracy; Fagan, Kelly; Finnila, Candice R.; Gavrilova, Ralitza; Genetti, Casie A.; Hiatt, Susan M.; Hildebrandt, Friedhelm; Wojcik, Monica H.; Kleefstra, Tjitske; Kolvenbach, Caroline M.; Korf, Bruce R.; Kruszka, Paul; Li, Hong; Litwin, Jessica; Marcadier, Julien; Platzer, Konrad; Blackburn, Patrick R.; Reijnders, Margot R.F.; Reutter, Heiko; Schanze, Ina; Shieh, Joseph T.; Stevens, Cathy A.; Valivullah, Zaheer; van den Boogaard, Marie José; Klee, Eric W.; Campeau, Philippe M. (2024-08)
    Bi-allelic disruptive variants (nonsense, frameshift, and splicing variants) in KDM5B have been identified as causative for autosomal recessive intellectual developmental disorder type 65. In contrast, dominant variants, usually disruptive as well, ...
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    The Icelandic Heart Failure Registry—A nationwide assessment tool for HF care and intervention in HF treatment 
    Ingimarsdóttir, Inga Jóna; Hansen, Johan Sindri; Bergmann, Hekla María; Einarsson, Hafsteinn (2024)
    Introduction: The incidence of heart failure (HF) is increasing, largely because populations are both ageing and growing. Most clinical HF treatment trials are conducted on selected cohorts, only a few of which include elderly patients, among whom HF ...

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