Opin vísindi
Opin vísindi er varðveislusafn vísindaefnis og doktorsritgerða í opnum aðgangi á vegum íslenskra háskóla og Landsbókasafns Íslands - Háskólabókasafns.
Opinn aðgangur að rannsóknaniðurstöðum er í samræmi við 10. gr. laga nr. 3/2003 um opinberan stuðning við vísindarannsóknir sem og kröfur innlendra og erlendra rannsóknasjóða. Markmiðið með opnum aðgangi er að niðurstöður rannsókna séu aðgengilegar sem flestum óhindrað og án endurgjalds á rafrænu formi. Vistun í varðveislusafninu er varanleg og ætlað að tryggja aðgang að vísindaefni íslenskra háskóla í opnum aðgangi um ókomna tíð. Varðveislusafnið Opin vísindi er tengt við rannsóknagáttina IRIS og rannsóknaniðurstöður í opnum aðgangi sem eru skráðar í IRIS eru um leið vistaðar og gerðar aðgengilegar til framtíðar í varðveislusafninu. Með því að safna þessu efni saman í eitt safn verður aðgangur að því einfaldur og þægilegur fyrir alla sem vilja kynna sér það og geta þannig notið þess öfluga vísindastarfs sem fram fer í háskólum landsins.
Varðveislusafnið er OpenAIRE / OpenAIREplus samhæft og samrýmist kröfum sem gerðar eru um birtingu rannsóknaniðurstaðna úr verkefnum sem styrkt eru úr evrópsku rannsóknaáætlununum FP7 og H2020.
Varðveislusafnið notar opna hugbúnaðinn DSpace.
Opinn aðgangur að rannsóknaniðurstöðum er í samræmi við 10. gr. laga nr. 3/2003 um opinberan stuðning við vísindarannsóknir sem og kröfur innlendra og erlendra rannsóknasjóða. Markmiðið með opnum aðgangi er að niðurstöður rannsókna séu aðgengilegar sem flestum óhindrað og án endurgjalds á rafrænu formi. Vistun í varðveislusafninu er varanleg og ætlað að tryggja aðgang að vísindaefni íslenskra háskóla í opnum aðgangi um ókomna tíð. Varðveislusafnið Opin vísindi er tengt við rannsóknagáttina IRIS og rannsóknaniðurstöður í opnum aðgangi sem eru skráðar í IRIS eru um leið vistaðar og gerðar aðgengilegar til framtíðar í varðveislusafninu. Með því að safna þessu efni saman í eitt safn verður aðgangur að því einfaldur og þægilegur fyrir alla sem vilja kynna sér það og geta þannig notið þess öfluga vísindastarfs sem fram fer í háskólum landsins.
Varðveislusafnið er OpenAIRE / OpenAIREplus samhæft og samrýmist kröfum sem gerðar eru um birtingu rannsóknaniðurstaðna úr verkefnum sem styrkt eru úr evrópsku rannsóknaáætlununum FP7 og H2020.
Varðveislusafnið notar opna hugbúnaðinn DSpace.
Flokkar í Opnum vísindum
Veldu flokk til að skoða.
- University of Iceland
- University of Akureyri
- Bifröst University
- Hólar University College
- Reykjavík University
- IRIS
- Agricultural University of Iceland
- National and University Library of Iceland
- Iceland University of the Arts
Nýlega bætt við
An experimental test of the habit-goal framework : Depressive rumination is associated with heightened habitual characteristics of negative thinking but not habit-directed behavior control
(2020) Hjartarson, Kristján Helgi; Snorrason, Ivar; Friðriksdóttir, Ágústa; Þórsdóttir, Brynja B.; Arnarsdóttir, Nína B.; Ólafsson, Ragnar P.; Faculty of Psychology
Habitual thinking may underpin a heightened disposition to engage in rumination in response to negative mood, a widely held notion that has rarely been directly tested. The purpose of the current study was to investigate whether rumination is associated with habitual attributes and whether it is related to an imbalance in habit relative to goal-directed behavior control. University students (N=115) completed self-report questionnaires, a rumination induction paradigm and an outcome devaluation task that measures habitual vs goal-directed behavior control. Greater habitual characteristics of negative thinking (e.g., automaticity, lack of conscious awareness, control, and intent) were associated with ruminative brooding but not ruminative reflection and predicted more persistent dysphoric mood following rumination induction. Rumination was not, however, consistently associated with an imbalance in habit versus goal-directed behavior control. These findings indicate that depression vulnerability may be in the form of rumination being habitually triggered (without awareness or intent) with deleterious effects on mood. Although habitual, rumination may not be related to an imbalance in habit relative to goal-directed behavior control. These findings provide support for current theoretical accounts of rumination and set important boundary conditions in the search for specific factors that contribute to rumination as a habit.
Do daily mood fluctuations activate ruminative thoughts as a mental habit? Results from an ecological momentary assessment study
(2021-05) Hjartarson, Kristján Helgi; Snorrason, Ivar; Bringmann, Laura F.; Ögmundsson, Bjarni E.; Ólafsson, Ragnar Pétur; Faculty of Psychology
It has been suggested that mental habits may underpin a heightened disposition to engage in rumination in response to negative mood. The aim of the current study was to assess the role of habit in the dynamic interplay between affect and ruminative thinking in the flow of daily life experiences. Using mobile ecological momentary assessment, 97 participants recorded affect and rumination ten times daily over six days, after completing measures of trait ruminative brooding and habitual characteristics of negative thinking (e.g. automaticity, lack of conscious awareness, intent and control). Momentary fluctuations in negative (increased) and positive (decreased) affect was prospectively associated with greater rumination-levels at the next sampling occasion. The degree to which affect triggered a subsequent ruminative response was moderated by habitual characteristics of negative thinking in a theoretically consistent way. Stronger temporal pairing of negative affect and rumination was also associated with greater emotional inertia but less carry-over of rumination from one moment to the next. Depression vulnerability may be in the form of rumination being habitually triggered in response to momentary fluctuations in affect, with deleterious effect on mood. The findings may have clinical implications, as targeting the habitual nature of rumination might help reduce depression vulnerability.
Education for social change : The case of teacher education in wales
(2021-07-31) Weicht, Rebecca; Jónsdóttir, Svanborg R.; Faculty of Education and Diversity
Entrepreneurial education offers valuable opportunities for teachers to foster and enhance creativity and action competence, which are also important for sustainability education. The University of Wales Trinity Saint David (UWTSD) is a leader in the development of entrepreneurial education in teacher education both in Wales and internationally. The objective of this article is to shed light on how an entrepreneurial education approach can help foster social change. The aim of this study is to learn from teacher educators at UWTSD about how they support creativity, innovation, and an enterprising mindset in their learners. A case study approach is applied. By analysing docu-mentary evidence such as module and assignment handbooks, we explore how teacher educators at UWTSD deliver entrepreneurial education for social change. Our findings indicate that UWTSD’s development of entrepreneurial education in teacher training has enabled constructive learning, cultivating creativity and action competence. We provide examples that display how the intentions of the Curriculum for Wales and entrepreneurial education approaches of the UWTSD emerge in practice. These examples show outcomes of the entrepreneurial projects that evince the enactment of social change. The findings also show that the educational policy of Wales supports entrepreneurial education throughout all levels of the educational system.
The importance of different frailty domains in a population based sample in England
(2020-01-15) Arnadottir, Solveig A.; Bruce, Julie; Lall, Ranjit; Withers, Emma J.; Underwood, Martin; Shaw, Fiona; Sheridan, Ray; Hossain, Anower; Lamb, Sarah E.; Martin, Finbarr; Yardley, Lucy; Skelton, Dawn; Willett, Keith; Eldridge, Sandra; Slowther, Anne Marie; Duggan, Sarah; Bruce, Julie; Hennings, Susie; Withers, Emma; Mant, Rhys; Rai, Rishpal; Turner, Craig; Andrews, Agata; Fearn, Rachael; Finnegan, Susanne; Walker, Nicola; Potter, Rachel; Lall, Ranjit; Hulme, Claire; Bojke, Chris; Longo, Roberta; Finnegan, Susanne; Westacott, Katherine; Ralhan, Shvaita; Sheridan, Ray; Treml, Jonathan; Sheridan, Ray; Riglin, Jackie; Gordjin, Harm; Dutta, Ruma; Burns, Jo; Treml, Jonathan; Shaw, Fiona; Davison, John; Willis, Ade; Muthiah, Chocks; Adjei, Henry; Faculty of Medicine
Background: The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, outdoor mobility, problems in self-care or usual activities, and lack of energy or accomplishment) in an English cohort by age and sex. Methods: Analysis of baseline data from a cohort of 9803 community-dwelling participants in a clinical trial. The sample was drawn from a random selection of all people aged 70 or more registered with 63 general practices across England. Data were collected by postal questionnaire. Frailty was measured with the Strawbridge questionnaire. We used cross sectional, multivariate logistic regression to estimate the association between frailty domains and known correlates and adjusted for age. Some models were stratified by sex. Results: Mean age of participants was 78 years (sd 5.7), range 70 to 101 and 47.5% (4653/9803) were men. The prevalence of overall frailty was 20.7% (2005/9671) and there was no difference in prevalence by sex (Odds Ratio 0.98; 95% Confidence Interval 0.89 to 1.08). Sensory frailty was the most common and this was reported by more men (1823/4586) than women (1469/5056; Odds Ratio for sensory frailty 0.62, 95% Confidence Interval 0.57 to 0.68). Men were less likely than women to have physical or nutritive frailty. Physical frailty had the strongest independent associations with adverse health states. However, sensory frailty was independently associated with falls, less frequent walking, problems in self-care and usual activities, lack of energy and accomplishment. Conclusions: Physical frailty was more strongly associated with adverse health states, but sensory frailty was much more common. The health gain from intervention for sensory frailty in England is likely to be substantial, particularly for older men. Sensory frailty should be explored further as an important target of intervention to improve health outcomes for older people both at clinical and population level.
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
(2021-03-03) Dillard, Pierre; Köksal, Hakan; Maggadóttir, Sólrún Melkorka; Winge-Main, Anna; Pollmann, Sylvie; Menard, Mathilde; Myhre, Marit Renée; Mælandsmo, Gunhild M.; Flørenes, Vivi Ann; Gaudernack, Gustav; Kvalheim, Gunnar; Wälchli, Sébastien; Inderberg, Else Marit; Faculty of Medicine
T cell receptor (TCR)-engineered T cell therapy is a promising cancer treatment approach. Human telomerase reverse transcriptase (hTERT) is overexpressed in the majority of tumors and a potential target for adoptive cell therapy. We isolated a novel hTERT-specific TCR sequence, named Radium-4, from a clinically responding pancreatic cancer patient vaccinated with a long hTERT peptide. Radium-4 TCR-redirected primary CD4 + and CD8 + T cells demonstrated in vitro efficacy, producing inflammatory cytokines and killing hTERT + melanoma cells in both 2D and 3D settings, as well as malignant, patient-derived ascites cells. Importantly, T cells expressing Radium-4 TCR displayed no toxicity against bone marrow stem cells or mature hematopoietic cells. Notably, Radium-4 TCR + T cells also significantly reduced tumor growth and improved survival in a xenograft mouse model. Since hTERT is a universal cancer antigen, and the very frequently expressed HLA class II molecules presenting the hTERT peptide to this TCR provide a very high (>75%) population coverage, this TCR represents an attractive candidate for immunotherapy of solid tumors.