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Model based smooth super-twisting control of cancer chemotherapy treatment
(2024-02) Rsetam, Kamal; Al-Rawi, Mohammad; Cao, Zhenwei; Alsadoon, Abeer; Wang, Lulu; Department of Engineering
Chemotherapy is one of the most efficient methods for treating cancer patients. Chemotherapy aims to eliminate cancer cells as thoroughly as possible. Delivering medications to patients’ bodies through various methods, either oral or intravenous is part of the chemotherapy process. Different cell-kill hypotheses take into account the interactions of the expansion of the tumor volume, external drugs, and the rate of their eradication. For the control of drug usage and tumor volume, a model based smooth super-twisting control (MBSSTC) is proposed in this paper. Firstly, three nonlinear cell-kill mathematical models are considered in this work, including the log-kill, Norton-Simon, and Emax hypotheses subject to parametric uncertainties and exogenous perturbations. In accordance with clinical recommendations, the tumor volume follows a predefined trajectory after chemotherapy. Secondly, the MBSSTC is applied for the three cell-kill models to attain accurate trajectory tracking even in the presence of uncertainties and disturbances. Compared to conventional super-twisting control (STC), the non-smooth term is introduced in the proposed control to enhance the anti-disturbance capability. Finally, simulation comparisons are performed across the proposed MBSSTC, conventional STC, and proportional–integral (PI) control methods to show the effectiveness and merits of our designed control method.
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Permutations Avoiding Bipartite Partially Ordered Patterns Have a Regular Insertion Encoding
(2024) Bean, Christian; Nadeau, Émile; Pantone, Jay; Ulfarsson, Henning; Department of Computer Science
We prove that any class of permutations defined by avoiding a partially ordered pattern (POP) with height at most two has a regular insertion encoding and thus has a rational generating function. Then, we use Combinatorial Exploration to find combinatorial specifications and generating functions for hundreds of other permutation classes defined by avoiding a size 5 POP, allowing us to resolve several conjectures of Gao and Kitaev (2019) and of Chen and Lin (2024).
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Microstrip Patch Antenna with an Inverted T-Type Notch in the Partial Ground for Breast Cancer Detections
(2024) Chowdhury, Nure Alam; Wang, Lulu; Islam, Md Shazzadul; Gu, Linxia; Kaya, Mehmet; Department of Engineering
This study designs a microstrip patch antenna with an inverted T-type notch in the partial ground to detect tumor cells inside the human breast. The size of the current antenna is small enough (18 mm × 21 mm × 1.6 mm) to distribute around the breast phantom. The operating frequency has been observed from 6–14 GHz with a minimum return loss of −61.18 dB and the maximum gain of current proposed antenna is 5.8 dBi which is flexible with respect to the size of antenna. After the distribution of eight antennas around the breast phantom, the return loss curves were observed in the presence and absence of tumor cells inside the breast phantom, and these observations show a sharp difference between the presence and absence of tumor cells. The simulated results show that this proposed antenna is suitable for early detection of cancerous cells inside the breast.
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The Role of Machine Learning in Cybersecurity
(2023-03-07) Apruzzese, Giovanni; Laskov, Pavel; Montes De Oca, Edgardo; Mallouli, Wissam; Brdalo Rapa, Luis; Grammatopoulos, Athanasios Vasileios; Di Franco, Fabio; Department of Computer Science
Machine Learning (ML) represents a pivotal technology for current and future information systems, and many domains already leverage the capabilities of ML. However, deployment of ML in cybersecurity is still at an early stage, revealing a significant discrepancy between research and practice. Such a discrepancy has its root cause in the current state of the art, which does not allow us to identify the role of ML in cybersecurity. The full potential of ML will never be unleashed unless its pros and cons are understood by a broad audience.This article is the first attempt to provide a holistic understanding of the role of ML in the entire cybersecurity domain - to any potential reader with an interest in this topic. We highlight the advantages of ML with respect to human-driven detection methods, as well as the additional tasks that can be addressed by ML in cybersecurity. Moreover, we elucidate various intrinsic problems affecting real ML deployments in cybersecurity. Finally, we present how various stakeholders can contribute to future developments of ML in cybersecurity, which is essential for further progress in this field. Our contributions are complemented with two real case studies describing industrial applications of ML as defense against cyber-threats.
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Mapping European high-digital intensive sectors—regional growth accelerator for the circular economy
(2023-01-06) Pirciog, Speranta Camelia; Grigorescu, Adriana; Lincaru, Cristina; Popa, Florin Marius; Lazarczyk Carlson, Ewa; Sigurdarson, Hallur Thor; Department of Business and Economics
Globalization and the Fourth Industrial Revolution or Industry 4.0 act as shocks on regional labor markets and regional economies. The presence of a digital economy has high spillover effects on regional development, job creation, economic resilience, and sustainability; furthermore, it valuates eco-innovation and the clean economy. We believe that the process of digital transformation has a robust impact on the green and clean aspects of the entire economy. The consistency of high digital-intensive (HDI) sectors can be evaluated through high digital-intensive employment, human resources, and technological infrastructure, as these are the main pillars of digital transformation. The shift-share analysis method (SSM) is used in this study on employment growth during 2008–2018 for the EU27, the United Kingdom, and Norway, combined with a second stage of exploratory spatial data analysis (ESDA). The findings on national growth, industrial mix, and competitiveness are presented in GIS mapping system considering the Local Indicators of Spatial Association (LISA) technique at the NUTS2 level. This approach allows us to determine the clustering level of high digital-intensive employment and sectors, resilience based on connectivity and eco-innovation, and the regional potential of digital transformation. Policymakers and political or governmental decision-makers could consider the results of the present study as the starting point for developing and implementing their policies for a sustainable green regional economy and determine the emerging area patches that need to be stimulated.

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