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Global, regional, and national levels of maternal mortality, 1990–2015 : a systematic analysis for the Global Burden of Disease Study 2015
(2016-10-08) Kassebaum, N. J.; Barber, R. M.; Dandona, L.; Hay, S. I.; Larson, H. J.; Lim, S. S.; Lopez, A. D.; Mokdad, A. H.; Naghavi, M.; Pinho, C.; Steiner, C.; Vos, T.; Wang, H.; Achoki, T.; Anderson, G. M.; Arora, M.; Biryukov, S.; Blore, J. D.; Carter, A.; Casey, D. C.; Coates, M. M.; Coggeshall, M.; Dicker, D. J.; Dossou, E.; Fleming, T.; Fraser, M. S.; Friedman, J.; Fullman, N.; Graetz, N.; Hancock, J.; Huynh, C.; Iannarone, M.; Kemmer, L.; Kulikoff, X. R.; Kutz, M. J.; Liu, P. Y.; Marquez, N.; Misganaw, A.; Mooney, M. D.; Moradi-Lakeh, M.; Ng, M.; Nguyen, G.; Pain, A.; Shackelford, K. A.; Silpakit, N.; Sligar, A.; Smith, J. M.; Sorensen, R. J.D.; Wang, L.; Sigfusdottir, I. D.; Department of Engineering; Department of Psychology
Background In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. Methods We estimated maternal mortality at the global, regional, and national levels from 1990 to 2015 for ages 10–54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories, 11 of which were analysed at the subnational level. We quantified eight underlying causes of maternal death and four timing categories, improving estimation methods since GBD 2013 for adult all-cause mortality, HIV-related maternal mortality, and late maternal death. Secondary analyses then allowed systematic examination of drivers of trends, including the relation between maternal mortality and coverage of specific reproductive health-care services as well as assessment of observed versus expected maternal mortality as a function of Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Findings Only ten countries achieved MDG 5, but 122 of 195 countries have already met SDG 3.1. Geographical disparities widened between 1990 and 2015 and, in 2015, 24 countries still had a maternal mortality ratio greater than 400. The proportion of all maternal deaths occurring in the bottom two SDI quintiles, where haemorrhage is the dominant cause of maternal death, increased from roughly 68% in 1990 to more than 80% in 2015. The middle SDI quintile improved the most from 1990 to 2015, but also has the most complicated causal profile. Maternal mortality in the highest SDI quintile is mostly due to other direct maternal disorders, indirect maternal disorders, and abortion, ectopic pregnancy, and/or miscarriage. Historical patterns suggest achievement of SDG 3.1 will require 91% coverage of one antenatal care visit, 78% of four antenatal care visits, 81% of in-facility delivery, and 87% of skilled birth attendance. Interpretation Several challenges to improving reproductive health lie ahead in the SDG era. Countries should establish or renew systems for collection and timely dissemination of health data; expand coverage and improve quality of family planning services, including access to contraception and safe abortion to address high adolescent fertility; invest in improving health system capacity, including coverage of routine reproductive health care and of more advanced obstetric care—including EmOC; adapt health systems and data collection systems to monitor and reverse the increase in indirect, other direct, and late maternal deaths, especially in high SDI locations; and examine their own performance with respect to their SDI level, using that information to formulate strategies to improve performance and ensure optimum reproductive health of their population. Funding Bill & Melinda Gates Foundation.
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Erratum : Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: The Global Burden of Disease Study 2015 (The Lancet HIV (2016) 3 (e361-e387) PII: S235230181630087X DOI: 10.1016/S2352-3018(16)30087-X)
(2016-09-01) GBD 2015 HIV Collaborators; Department of Psychology
GBD 2015 HIV Collaborators. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. Lancet HIV 2016; 3: e361–87—In this Article, Kerrie E Doyle and David M Pereira have been added to the list of collaborators and Claudia C Pereira has been removed. These corrections have been made as of Aug 22, 2016.
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Predictive models of the 2015 Rugby World Cup : Accuracy and application
(2016-07) O'Donoghue, P.; Ball, D.; Eustace, J.; McFarlan, B.; Nisotaki, M.; Department of Sport Science
The current investigation compared 12 models of outcomes of international rugby union matches and then used the most accurate model to investigate performances within the 2015 Rugby World Cup. The underlying linear regression models were used within a simulation package that introduced random variability about performance evidenced by the residual distribution of the regression analyses. Each model was used within 10,000 simulations of the 2015 Rugby World Cup from which match outcome and team progression statistics were recorded. The most accurate model with respect to the actual 2015 tournament was developed using data from all seven previous tournaments rather than restricting cases to the most recent three tournaments. The model was more accurate when the data used violated the assumptions of linear regression rather than transforming variables to satisfy the assumptions. The model included World ranking points as a predictor variable and was more accurate than corresponding models that represented relative home advantage as well. The most accurate model used separate models for the pool and knockout stage matches although the 9 models that separating these match types were less accurate on average than when the two match types were considered together. This model was used to investigate properties of the 2015 Rugby World Cup. The tournament disadvantaged three teams in the World's top 5 who were drawn in the same pool. Teams ranked in the World's top 7 did not perform as well as predicted while teams ranked 16th and below performed better than predicted suggesting that the strength in depth in international rugby union is increasing. There was a small effect of having additional recovery days from the previous match compared to the opponents which was worth 4.1 points. The information produced by this research should be considered by those design tournaments such as the Rugby World Cup.
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Learning rules of simplified boardgames by observing
(IOS Press BV, 2012) Björnsson, Yngvi; Department of Computer Science
General Game Playing (GGP) agents learn strategies to skillfully play a wide variety of games when given only the rules of the game. The rules are provided in a language called Game Description Language (GDL) and specify the initial game setup, what constitutes legal moves and how they update the game state when played, how the game terminates, and what the outcome is. In here we extend this line of research further, that is, we assume that the game-playing agent must learn the rules of a game by observing others play instead of them being provided. Our focus here will mainly be on modeling piece movements with less attention placed on the remaining game-rule properties. We define a subset of games, we name simplified boardgames, that despite constituting only a small subset of games expressible in GDL nonetheless encapsulate a large variety of interesting piece movement patterns found in popular boardgames. We provide a well-defined formalism and a practicable algorithm for learning game rules of simplified boardgames. We empirically evaluate the learning algorithm on different boardgames and under different assumptions of availability of observations. Furthermore, we show that our formalism offers at least an order of magnitude speedup over state-of-the-art logic-based GDL reasoners for fitting boardgames. The method is thus directly relevant for GGP systems.
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Case-based subgoaling in real-time heuristic search for video game pathfinding
(2010) Bulitko, Vadim; Björnsson, Yngvi; Lawrence, Ramon; Department of Computer Science
Real-time heuristic search algorithms satisfy a constant bound on the amount of planning per action, independent of problem size. As a result, they scale up well as problems become larger. This property would make them well suited for video games where Artificial Intelligence controlled agents must react quickly to user commands and to other agents' actions. On the downside, real-time search algorithms employ learning methods that frequently lead to poor solution quality and cause the agent to appear irrational by re-visiting the same problem states repeatedly. The situation changed recently with a new algorithm, D LRTA*, which attempted to eliminate learning by automatically selecting subgoals. D LRTA* is well poised for video games, except it has a complex and memory-demanding pre-computation phase during which it builds a database of subgoals. In this paper, we propose a simpler and more memory-efficient way of pre-computing subgoals thereby eliminating the main obstacle to applying state-of-the-art real-time search methods in video games. The new algorithm solves a number of randomly chosen problems off-line, compresses the solutions into a series of subgoals and stores them in a database. When presented with a novel problem on-line, it queries the database for the most similar previously solved case and uses its subgoals to solve the problem. In the domain of pathfinding on four large video game maps, the new algorithm delivers solutions eight times better while using 57 times less memory and requiring 14% less pre-computation time.

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