dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Thrainsson, Leifur |
dc.contributor.author |
Halldorsson, Arnljotur Bjorn |
dc.contributor.author |
Ingason, Arnar Bragi |
dc.contributor.author |
Ísaksson, Helgi Jóhannes |
dc.contributor.author |
Guðmundsson, Gunnar |
dc.contributor.author |
Guðbjartsson, Tómas |
dc.date.accessioned |
2024-02-22T01:14:33Z |
dc.date.available |
2024-02-22T01:14:33Z |
dc.date.issued |
2024-01 |
dc.identifier.citation |
Thrainsson , L , Halldorsson , A B , Ingason , A B , Ísaksson , H J , Guðmundsson , G & Guðbjartsson , T 2024 , ' Surgical lung biopsy for suspected interstitial lung disease with video-assisted thoracoscopic surgery is safe, providing exact histological and disease specific diagnosis for tailoring treatment ' , Journal of Thoracic Disease , vol. 16 , no. 1 , pp. 99-112 . https://doi.org/10.21037/jtd-23-1107 |
dc.identifier.issn |
2072-1439 |
dc.identifier.other |
217480027 |
dc.identifier.other |
e463cb60-23f4-4697-8719-11413eb21bbd |
dc.identifier.other |
85183950006 |
dc.identifier.other |
38410568 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4736 |
dc.description |
Publisher Copyright: © 2024 AME Publishing Company. All rights reserved. |
dc.description.abstract |
BACKGROUND: Surgical lung biopsy (SLB) is required for diagnosis in patients with suspected interstitial lung disease (ILD) if other less invasive diagnostic methods are non-conclusive. We evaluated the outcome of SLB by using centralized databases in a whole-nation patient-cohort. METHODS: A population-based retrospective study on 68 consecutive patients (mean age 58 years, 58.8% males) that underwent SLB in Iceland between the years 2008 and 2020. Patient information was obtained from patient charts and peri- and postoperative complications were registered together with 30- and 90-day mortality. Computed tomography (CT) scans, histological biopsies and spirometry results were reviewed, and overall survival (Kaplan-Meier) estimated. Mean follow-up was 61.3 months (range, 3-155 months). RESULTS: Out of 68 SLB-patients 41 (60.3%) had preoperatively undergone non-conclusive transbronchial biopsies (TBB) obtained with bronchoscopy. Spirometry showed forced vital capacity (FVC) 3.0 L and forced expiratory volume in 1 second (FEV1) 2.3 L, or 73.0% and 71.6% of predicted value, respectively. Video-assisted thoracoscopic surgery (VATS) technique was used in all cases and provided a histologic and disease specific diagnosis in 92.6% of cases; most often being nonspecific interstitial pneumonia (NSIP) (29.4%) and usual interstitial pneumonia (UIP) (23.5%). One patient (1.5%) sustained a major postoperative complication (excessive bleeding) and seven patients (10.3%) minor complications. Median chest tube time and length of stay was 1 and 2 days, respectively. No patients died <90 days postoperatively. Overall survival at 1 and 5 years was 95.6% and 73.5%, respectively, and 5-year survival for NSIP and UIP was 85% and 43.7%, respectively. Long-term mortality for UIP was four times higher when compared with NSIP and other diagnosis. CONCLUSIONS: Lung biopsy with VATS-technique provided a definitive histological and disease specific diagnosis in majority of cases. The procedure is safe, reflected in low complication-rates and short hospital stay, and can therefore be used to diagnose and tailor treatment of ILD patients. |
dc.format.extent |
14 |
dc.format.extent |
321467 |
dc.format.extent |
99-112 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Journal of Thoracic Disease; 16(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Meinafræði |
dc.subject |
Lungnalæknisfræði |
dc.subject |
Hjarta- og lungnaskurðlæknisfræði |
dc.subject |
30-day mortality |
dc.subject |
histology |
dc.subject |
Interstitial lung disease (ILD) |
dc.subject |
surgical biopsy |
dc.subject |
video-assisted thoracoscopic surgery (VATS) |
dc.subject |
Pulmonary and Respiratory Medicine |
dc.title |
Surgical lung biopsy for suspected interstitial lung disease with video-assisted thoracoscopic surgery is safe, providing exact histological and disease specific diagnosis for tailoring treatment |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.21037/jtd-23-1107 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85183950006&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.department |
Other departments |