dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Þórarinsdóttir, Katrín |
dc.contributor.author |
McGrath, Sarah |
dc.contributor.author |
Forslind, Kristina |
dc.contributor.author |
Agelii, Monica Leu |
dc.contributor.author |
Ekwall, Anna-Karin Hultgård |
dc.contributor.author |
Jacobsson, Lennart T H |
dc.contributor.author |
Rudin, Anna |
dc.contributor.author |
Mårtensson, Inga-Lill |
dc.contributor.author |
Gjertsson, Inger |
dc.date.accessioned |
2024-02-22T01:14:31Z |
dc.date.available |
2024-02-22T01:14:31Z |
dc.date.issued |
2024-01-15 |
dc.identifier.citation |
Þórarinsdóttir , K , McGrath , S , Forslind , K , Agelii , M L , Ekwall , A-K H , Jacobsson , L T H , Rudin , A , Mårtensson , I-L & Gjertsson , I 2024 , ' Cartilage destruction in early rheumatoid arthritis patients correlates with CD21-/low double-negative B cells ' , Arthritis research & therapy , vol. 26 , no. 1 , 23 , pp. 23 . https://doi.org/10.1186/s13075-024-03264-2 |
dc.identifier.issn |
1478-6362 |
dc.identifier.other |
217479745 |
dc.identifier.other |
17af0967-a66c-47a2-991f-5c97123ce278 |
dc.identifier.other |
38225658 |
dc.identifier.other |
PubMedCentral: PMC10789032 |
dc.identifier.other |
85182496927 |
dc.identifier.other |
unpaywall: 10.1186/s13075-024-03264-2 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4735 |
dc.description |
Publisher Copyright: © 2024, The Author(s). |
dc.description.abstract |
BACKGROUND: Involvement of B cells in the pathogenesis of rheumatoid arthritis (RA) is supported by the presence of disease-specific autoantibodies and the efficacy of treatment directed against B cells. B cells that express low levels of or lack the B cell receptor (BCR) co-receptor CD21, CD21-/low B cells, have been linked to autoimmune diseases, including RA. In this study, we characterized the CD21+ and CD21-/low B cell subsets in newly diagnosed, early RA (eRA) patients and investigated whether any of the B cell subsets were associated with autoantibody status, disease activity and/or joint destruction. METHODS: Seventy-six eRA patients and 28 age- and sex-matched healthy donors were recruited. Multiple clinical parameters were assessed, including disease activity and radiographic joint destruction. B cell subsets were analysed in peripheral blood (PB) and synovial fluid (SF) using flow cytometry. RESULTS: Compared to healthy donors, the eRA patients displayed an elevated frequency of naïve CD21+ B cells in PB. Amongst memory B cells, eRA patients had lower frequencies of the CD21+CD27+ subsets and CD21-/low CD27+IgD+ subset. The only B cell subset found to associate with clinical factors was the CD21-/low double-negative (DN, CD27-IgD-) cell population, linked with the joint space narrowing score, i.e. cartilage destruction. Moreover, in SF from patients with established RA, the CD21-/low DN B cells were expanded and these cells expressed receptor activator of the nuclear factor κB ligand (RANKL). CONCLUSIONS: Cartilage destruction in eRA patients was associated with an expanded proportion of CD21-/low DN B cells in PB. The subset was also expanded in SF from established RA patients and expressed RANKL. Taken together, our results suggest a role for CD21-/low DN in RA pathogenesis. |
dc.format.extent |
1225274 |
dc.format.extent |
23 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Arthritis research & therapy; 26(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Gigtarlæknisfræði |
dc.subject |
Humans |
dc.subject |
B-Lymphocytes |
dc.subject |
Arthritis, Rheumatoid/pathology |
dc.subject |
B-Lymphocyte Subsets |
dc.subject |
Synovial Fluid |
dc.subject |
Autoantibodies |
dc.subject |
Cartilage/pathology |
dc.subject |
Cartilage destruction |
dc.subject |
CD21 DN B cells |
dc.subject |
Early rheumatoid arthritis |
dc.subject |
Rheumatology |
dc.subject |
Immunology and Allergy |
dc.subject |
Immunology |
dc.title |
Cartilage destruction in early rheumatoid arthritis patients correlates with CD21-/low double-negative B cells |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1186/s13075-024-03264-2 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85182496927&partnerID=8YFLogxK |