dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Emilsson, Össur Ingi |
dc.contributor.author |
Aspelund, Thor |
dc.contributor.author |
Janson, Christer |
dc.contributor.author |
Benediktsdóttir, Bryndís |
dc.contributor.author |
Juliusson, Sigurdur |
dc.contributor.author |
Maislin, Greg |
dc.contributor.author |
Pack, Allan I |
dc.contributor.author |
Keenan, Brendan T |
dc.contributor.author |
Gíslason, Þórarinn |
dc.date.accessioned |
2023-11-04T01:05:16Z |
dc.date.available |
2023-11-04T01:05:16Z |
dc.date.issued |
2023-09 |
dc.identifier.citation |
Emilsson , Ö I , Aspelund , T , Janson , C , Benediktsdóttir , B , Juliusson , S , Maislin , G , Pack , A I , Keenan , B T & Gíslason , Þ 2023 , ' Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux : the Icelandic Sleep Apnea Cohort Study ' , ERJ Open Research , vol. 9 , no. 5 , 00387-2023 . https://doi.org/10.1183/23120541.00387-2023 |
dc.identifier.issn |
2312-0541 |
dc.identifier.other |
197603849 |
dc.identifier.other |
6b36b20a-7c92-4cb6-b7c9-c8c8ea0f32ae |
dc.identifier.other |
37817868 |
dc.identifier.other |
PubMedCentral: PMC10561083 |
dc.identifier.other |
85175334653 |
dc.identifier.other |
unpaywall: 10.1183/23120541.00387-2023 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4523 |
dc.description |
Publisher Copyright: © The authors 2023. |
dc.description.abstract |
AIM: To study the effect of positive airway pressure (PAP) treatment on nocturnal gastro-oesophageal reflux (nGOR) and respiratory symptoms among clinical obstructive sleep apnoea (OSA) patients. METHODS: 822 patients newly diagnosed with OSA referred for PAP treatment were recruited. 732 patients had a 2-year follow-up visit with continuous PAP compliance data (366 full PAP users, 366 partial/non-PAP users). They answered questionnaires, including reporting of nGOR, sleep and respiratory symptoms and general health. Patients with nGOR symptoms once a week or more were defined as "with nGOR". Those without nGOR symptoms and nGOR medication were defined as "no nGOR". Others were defined as "possible nGOR". RESULTS: At 2-year follow-up, PAP treatment among full users resulted in decreased nGOR (adjusted OR 0.58, 95% CI 0.40-0.86) and wheezing (adjusted OR 0.56, 95% CI 0.35-0.88) compared with partial/non-PAP users. Decreased nGOR, among both full and partial/non-users of PAP treatment, was associated with a decrease in productive morning cough (adjusted OR 4.70, 95% CI 2.22-9.99) and a decrease in chronic bronchitis (adjusted OR 3.86, 95% CI 1.74-8.58), but not decreased wheezing (adjusted OR 0.90, 95% CI 0.39-2.08). A mediation analysis found that PAP treatment directly led to a decrease in wheezing, not mediated through nGOR. Conversely, PAP treatment decreased productive cough mediated through a decrease in nGOR. CONCLUSION: In an unselected group of OSA patients, PAP treatment for 2 years was associated with a decrease in nGOR and respiratory symptoms. The PAP treatment itself was associated with less wheezing. A decrease in nGOR through PAP treatment was associated with a decrease in productive cough. |
dc.format.extent |
514493 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
ERJ Open Research; 9(5) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Lungnalæknisfræði |
dc.subject |
Háls-, nef- og eyrnalækningar |
dc.subject |
Pulmonary and Respiratory Medicine |
dc.title |
Positive airway pressure treatment affects respiratory symptoms and gastro-oesophageal reflux : the Icelandic Sleep Apnea Cohort Study |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1183/23120541.00387-2023 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85175334653&partnerID=8YFLogxK |
dc.contributor.department |
Faculty of Medicine |
dc.contributor.school |
Health Sciences |