dc.contributor.author |
Gatto, Nicole M |
dc.contributor.author |
Freund, Debbie |
dc.contributor.author |
Ogata, Pamela |
dc.contributor.author |
Diaz, Lisa |
dc.contributor.author |
Ibarrola, Ace |
dc.contributor.author |
Desai, Mamta |
dc.contributor.author |
Aspelund, Thor |
dc.contributor.author |
Gluckstein, Daniel |
dc.date.accessioned |
2023-08-22T01:04:44Z |
dc.date.available |
2023-08-22T01:04:44Z |
dc.date.issued |
2023-01-10 |
dc.identifier.citation |
Gatto , N M , Freund , D , Ogata , P , Diaz , L , Ibarrola , A , Desai , M , Aspelund , T & Gluckstein , D 2023 , ' Correlates of Coronavirus Disease 2019 Inpatient Mortality at a Southern California Community Hospital With a Predominantly Hispanic/Latino Adult Population ' , Open Forum Infectious Diseases , vol. 10 , no. 1 , pp. ofad011 . https://doi.org/10.1093/ofid/ofad011 |
dc.identifier.issn |
2328-8957 |
dc.identifier.other |
155765970 |
dc.identifier.other |
7d7a518f-43b5-43b7-a1d5-2c83b124d56b |
dc.identifier.other |
36726553 |
dc.identifier.other |
PubMedCentral: PMC9887269 |
dc.identifier.other |
unpaywall: 10.1093/ofid/ofad011 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4444 |
dc.description |
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. Financial support. None. |
dc.description.abstract |
BACKGROUND: Studies of inpatient coronavirus disease 2019 (COVID-19) mortality risk factors have mainly used data from academic medical centers or large multihospital databases and have not examined populations with large proportions of Hispanic/Latino patients. In a retrospective cohort study of 4881 consecutive adult COVID-19 hospitalizations at a single community hospital in Los Angeles County with a majority Hispanic/Latino population, we evaluated factors associated with mortality. METHODS: Data on demographic characteristics, comorbidities, laboratory and clinical results, and COVID-19 therapeutics were abstracted from the electronic medical record. Cox proportional hazards regression modeled statistically significant, independently associated predictors of hospital mortality. RESULTS: Age ≥65 years (hazard ratio [HR] = 2.66; 95% confidence interval [CI] = 1.90-3.72), male sex (HR = 1.31; 95% CI = 1.07-1.60), renal disease (HR = 1.52; 95% CI = 1.18-1.95), cardiovascular disease (HR = 1.45; 95% CI = 1.18-1.78), neurological disease (HR = 1.84; 95% CI = 1.41-2.39), D-dimer ≥500 ng/mL (HR = 2.07; 95% CI = 1.43-3.0), and pulse oxygen level <88% (HR = 1.39; 95% CI = 1.13-1.71) were independently associated with increased mortality. Patient household with (1) multiple COVID-19 cases and (2) Asian, Black, or Hispanic compared with White non-Hispanic race/ethnicity were associated with reduced mortality. In hypoxic COVID-19 inpatients, remdesivir, tocilizumab, and convalescent plasma were associated with reduced mortality, and corticosteroid use was associated with increased mortality. CONCLUSIONS: We corroborate several previously identified mortality risk factors and find evidence that the combination of factors associated with mortality differ between populations. |
dc.format.extent |
864802 |
dc.format.extent |
ofad011 |
dc.language.iso |
en |
dc.relation.ispartofseries |
Open Forum Infectious Diseases; 10(1) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.title |
Correlates of Coronavirus Disease 2019 Inpatient Mortality at a Southern California Community Hospital With a Predominantly Hispanic/Latino Adult Population |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1093/ofid/ofad011 |
dc.contributor.department |
Faculty of Medicine |