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Intake of vitamin B12 in relation to vitamin B12 status in groups susceptible to deficiency : a systematic review

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dc.contributor.author Bärebring, Linnea
dc.contributor.author Lamberg-Allardt, Christel
dc.contributor.author Thorisdottir, Birna
dc.contributor.author Ramel, Alfons
dc.contributor.author Söderlund, Fredrik
dc.contributor.author Arnesen, Erik Kristoffer
dc.contributor.author Nwaru, Bright I.
dc.contributor.author Dierkes, Jutta
dc.contributor.author Åkesson, Agneta
dc.date.accessioned 2023-08-15T01:06:58Z
dc.date.available 2023-08-15T01:06:58Z
dc.date.issued 2023-06-30
dc.identifier.citation Bärebring , L , Lamberg-Allardt , C , Thorisdottir , B , Ramel , A , Söderlund , F , Arnesen , E K , Nwaru , B I , Dierkes , J & Åkesson , A 2023 , ' Intake of vitamin B12 in relation to vitamin B12 status in groups susceptible to deficiency : a systematic review ' , Food and Nutrition Research , vol. 67 , 8626 . https://doi.org/10.29219/fnr.v67.8626
dc.identifier.issn 1654-6628
dc.identifier.other 168607106
dc.identifier.other 353a905b-d158-40b3-92c7-fc5696b7cf8d
dc.identifier.other 85164204140
dc.identifier.other unpaywall: 10.29219/fnr.v67.8626
dc.identifier.uri https://hdl.handle.net/20.500.11815/4415
dc.description Funding Information: This systematic review was conducted according to the guidelines for systematic reviews, developed for the 2022 revision of the NNR (10, 11) and preferred reporting for systematic reviews (12). The NNR 2022 is funded by the Nordic Council of Ministers and governmental food and health authorities of Norway, Finland, Sweden, Denmark and Iceland (13). A study protocol was published prior to article selection in database PROSPERO (https://www. crd.york.ac.uk, CRD42021244376). Publisher Copyright: © The Authors.
dc.description.abstract Objective: To systematically review the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency. Methods: We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Scopus up to 21 May 2021, for intervention studies, prospective cohort studies and case-control studies assessing B12 intake from diet and/or supplements in relation to B12 status (s/p-B12, holotranscobalamin, methylmalonic acid, homocysteine or breastmilk B12). Cross-sectional studies were eligible for studies conducted during pregnancy and lactation. Included populations were children (0–18 years), young adults (18–35 years), pregnant or lactating women, older adults (≥65 years) and vegans or vegetarians. Study selection, data extraction and risk of bias assessment were conducted by two assessors independently. The evidence was synthesized qualitatively and classified according to the World Cancer Research Fund. Results: The searches yielded 4855 articles of which 89 were assessed in full text and 18 included. Three studies were conducted during pregnancy and three during lactation or infancy – all observational. Eight studies were conducted among older adults; most were interventions among B12-deficient participants. Four studies were eligible for vegetarian and vegans, all interventions. The strength of evidence that habitual B12 intake or an intake in line with the current Nordic recommended intake (RI) is sufficient to ensure adequate status was considered Limited – no conclusion for all included populations. Conclusion: Evidence is insufficient to assess if or which level of B12 intake is sufficient to maintain adequate status for all included populations. Population-based cohort studies and low-to-moderate dose interventions that address this question are highly warranted.
dc.format.extent 1602630
dc.language.iso en
dc.relation.ispartofseries Food and Nutrition Research; 67()
dc.rights info:eu-repo/semantics/openAccess
dc.subject cobalamin
dc.subject dietary guidelines
dc.subject holotranscobalamin
dc.subject homocysteine
dc.subject methylmalonic acid
dc.subject vitamin B12
dc.subject Food Science
dc.subject Nutrition and Dietetics
dc.subject Public Health, Environmental and Occupational Health
dc.title Intake of vitamin B12 in relation to vitamin B12 status in groups susceptible to deficiency : a systematic review
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview
dc.description.version Peer reviewed
dc.identifier.doi 10.29219/fnr.v67.8626
dc.relation.url http://www.scopus.com/inward/record.url?scp=85164204140&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition
dc.contributor.school Health Sciences

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