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Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources

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dc.contributor.author EFSA Scientific Committee
dc.date.accessioned 2023-07-01T01:05:36Z
dc.date.available 2023-07-01T01:05:36Z
dc.date.issued 2023-01-17
dc.identifier.citation EFSA Scientific Committee 2023 , ' Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources ' , EFSA Journal , vol. 21 , no. 1 , e07728 , pp. e07728 . https://doi.org/10.2903/j.efsa.2023.7728
dc.identifier.issn 1831-4732
dc.identifier.other PURE: 155774779
dc.identifier.other PURE UUID: ee555e96-c3f1-416d-88b3-e2ae67fc389d
dc.identifier.other Scopus: 85147371531
dc.identifier.other unpaywall: 10.2903/j.efsa.2023.7728
dc.identifier.uri https://hdl.handle.net/20.500.11815/4369
dc.description © 2023 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.
dc.description.abstract Copper is an essential micronutrient and also a regulated product used in organic and in conventional farming pest management. Both deficiency and excessive exposure to copper can have adverse health effects. In this Scientific Opinion, the EFSA 2021 harmonised approach for establishing health-based guidance values (HBGVs) for substances that are regulated products and also nutrients was used to resolve the divergent existing HBGVs for copper. The tightly regulated homeostasis prevents toxicity manifestation in the short term, but the development of chronic copper toxicity is dependent on copper homeostasis and its tissue retention. Evidence from Wilson disease suggests that hepatic retention is indicative of potential future and possibly sudden onset of copper toxicity under conditions of continuous intake. Hence, emphasis was placed on copper retention as an early marker of potential adverse effects. The relationships between (a) chronic copper exposure and its retention in the body, particularly the liver, and (b) hepatic copper concentrations and evidence of toxicity were examined. The Scientific Committee (SC) concludes that no retention of copper is expected to occur with intake of 5 mg/day and established an Acceptable Daily Intake (ADI) of 0.07 mg/kg bw. A refined dietary exposure assessment was performed, assessing contribution from dietary and non-dietary sources. Background copper levels are a significant source of copper. The contribution of copper from its use as plant protection product (PPP), food and feed additives or fertilisers is negligible. The use of copper in fertilisers or PPPs contributes to copper accumulation in soil. Infant formula and follow-on formula are important contributors to dietary exposure of copper in infants and toddlers. Contribution from non-oral sources is negligible. Dietary exposure to total copper does not exceed the HBGV in adolescents, adults, elderly and the very elderly. Neither hepatic copper retention nor adverse effects are expected to occur from the estimated copper exposure in children due to higher nutrient requirements related to growth.
dc.format.extent e07728
dc.language.iso en
dc.relation.ispartofseries EFSA Journal; 21(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject copper
dc.subject exposure assessment
dc.subject health-based guidance value
dc.subject Parasitology
dc.subject Food Science
dc.subject Microbiology
dc.subject Animal Science and Zoology
dc.subject Veterinary (miscellaneous)
dc.subject Plant Science
dc.title Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36694841
dc.identifier.doi https://doi.org/10.2903/j.efsa.2023.7728
dc.relation.url http://www.scopus.com/inward/record.url?scp=85147371531&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition

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