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Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements : Results From the UK Biobank Resource

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dc.contributor University of Iceland
dc.contributor.author Styrkarsdottir, Unnur
dc.contributor.author Lund, Sigrun H
dc.contributor.author Thorleifsson, Gudmar
dc.contributor.author Saevarsdottir, Saedis
dc.contributor.author Gudbjartsson, Daniel F
dc.contributor.author Thorsteinsdottir, Unnur
dc.contributor.author Stefansson, Kari
dc.date.accessioned 2023-04-22T01:04:44Z
dc.date.available 2023-04-22T01:04:44Z
dc.date.issued 2023-04
dc.identifier.citation Styrkarsdottir , U , Lund , S H , Thorleifsson , G , Saevarsdottir , S , Gudbjartsson , D F , Thorsteinsdottir , U & Stefansson , K 2023 , ' Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements : Results From the UK Biobank Resource ' , Arthritis & rheumatology (Hoboken, N.J.) , vol. 75 , no. 4 , pp. 544-552 . https://doi.org/10.1002/art.42376
dc.identifier.issn 2326-5191
dc.identifier.other 70225611
dc.identifier.other 89ba98fa-b228-4e4a-bbfe-24d54f362d5f
dc.identifier.other 36239377
dc.identifier.other unpaywall: 10.1002/art.42376
dc.identifier.other 85142137935
dc.identifier.uri https://hdl.handle.net/20.500.11815/4151
dc.description Funding Information: Supported by deCODE genetics/Amgen Inc. Publisher Copyright: © 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
dc.description.abstract OBJECTIVE: The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an independent population. METHODS: In this study, 1,462 plasma proteins were measured in 54,265 participants from the UK Biobank on the Olink Explore platform. We analyzed the association of plasma proteins with prevalent OA, incident OA, and progression to joint replacement. We assessed the specificity of OA association through comparison of associations with inflammatory joint diseases and with previous joint replacement. RESULTS: The CRTAC1 protein showed the strongest association with prevalent knee OA (odds ratio [OR] 1.34 [95% confidence interval (95% CI) 1.27, 1.41]) and was associated with hip OA (OR 1.19 [95% CI 1.11, 1.28]). It predicted incident diagnosis of OA in the knee (hazard ratio [HR] 1.40 [95% CI 1.35, 1.46]) and hip (HR 1.25 [95% CI 1.19, 1.31]), as well as progression to joint replacement (HR 1.20 [95% CI 1.08, 1.33] for the knee and HR 1.22 [95% CI 1.08, 1.38] for the hip), while no association was found with inflammatory joint diseases. Individuals in the highest quintile of risk based on CRTAC1 level, age, sex, and body mass index had a 10-fold risk of knee or hip OA within 5 years compared to those in the lowest quintile. Adding aggrecan core protein (ACAN) and neurocan core protein (NCAN) to the model improved the prediction of OA but not joint replacement. Furthermore, we replicated the association of CUB domain-containing protein 1 with prior joint replacement. CONCLUSION: Plasma CRTAC1 is a specific biomarker for OA and a predictor of OA risk and progression to joint replacement. Adding ACAN and NCAN protein levels to the CRTAC1 model improved the prediction of OA.
dc.format.extent 9
dc.format.extent 603934
dc.format.extent 544-552
dc.language.iso en
dc.relation.ispartofseries Arthritis & rheumatology (Hoboken, N.J.); 75(4)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Gigtarlæknisfræði
dc.subject Arthroplasty, Replacement
dc.subject Calcium-Binding Proteins
dc.subject Cartilage
dc.subject Humans
dc.subject Osteoarthritis, Hip/epidemiology
dc.subject Osteoarthritis, Knee/epidemiology
dc.subject United Kingdom/epidemiology
dc.subject Immunology and Allergy
dc.subject Rheumatology
dc.subject Immunology
dc.title Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements : Results From the UK Biobank Resource
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1002/art.42376
dc.relation.url http://www.scopus.com/inward/record.url?scp=85142137935&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Internal Medicine and Emergency Services
dc.contributor.school Health Sciences


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