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Food hypersensitivity : an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample

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dc.contributor.author Lam, Holly C.Y.
dc.contributor.author Neukirch, Catherine
dc.contributor.author Janson, Christer
dc.contributor.author Garcia-Aymerich, Judith
dc.contributor.author Clausen, Michael Valur
dc.contributor.author Idrose, N. Sabrina
dc.contributor.author Demoly, Pascal
dc.contributor.author Bertelsen, Randi J.
dc.contributor.author Ruiz, Lidia C.
dc.contributor.author Raherison, Chantal
dc.contributor.author Jarvis, Deborah L.
dc.date.accessioned 2023-04-05T01:05:00Z
dc.date.available 2023-04-05T01:05:00Z
dc.date.issued 2023-08
dc.identifier.citation Lam , H C Y , Neukirch , C , Janson , C , Garcia-Aymerich , J , Clausen , M V , Idrose , N S , Demoly , P , Bertelsen , R J , Ruiz , L C , Raherison , C & Jarvis , D L 2023 , ' Food hypersensitivity : an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample ' , European Journal of Clinical Nutrition , vol. 77 , no. 8 , pp. 833-840 . https://doi.org/10.1038/s41430-023-01284-w
dc.identifier.issn 0954-3007
dc.identifier.other PURE: 113531222
dc.identifier.other PURE UUID: bf38dc9d-f1f6-4dab-8b25-83db1196543d
dc.identifier.other Scopus: 85150632974
dc.identifier.other unpaywall: 10.1038/s41430-023-01284-w
dc.identifier.uri https://hdl.handle.net/20.500.11815/4135
dc.description Funding Information: HCYL is supported by the Medical Research Council Centre for Environment and Health. NSI is supported by the Centre for Food and Allergy Research (NHMRC Centre of Research Excellence) PhD scholarship and the Melbourne Children’s LifeCourse top-up PhD scholarship (Royal Children’s Hospital Foundation grant #2018-984). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and the Generalitat de Catalunya through the CERCA Program. Publisher Copyright: © 2023, The Author(s). © 2023. The Author(s).
dc.description.abstract Background/Objectives: Food hypersensitivity (FHS) is common, but little is known about the factors associated with severe reactions, age of onset and whether sensitization persists. This study examines the factors associated with self-reported severe food reactions, onset age and the changes in prevalence of sensitization to foods over time in an adult sample. Subjects/Methods: We used data from adults taking part in the European Community Respiratory Health Survey (ECRHS) III (2010–2014) who provided information on food hypersensitivity, including symptoms, suspected culprit food and onset age (n = 4865). A subsample from six countries had serum food-specific IgE tested for 25 core foods and also in 10 years earlier (ECRHS II). We applied logistic regression and McNemar’s test for analyses. Results: The prevalence of self-reported FHS was 13.5% at ECRHS III. Of those providing information on symptoms (n = 611), 26.4% reported severe reactions. About 80% of 1033 reported food-specific reactions (reported by 596 participants) began after age 15. History of asthma (odds ratio OR 2.12 95% confidence interval CI 1.13–3.44) and a younger age of onset of FHS (OR 1.02, 95% CI 1.01–1.03, per year) were associated with higher risks of a lifetime experience of severe food reactions. In the subsample with IgE tested in both surveys (n = 1612), the overall prevalence of sensitization to foods did not change over 10 years. Conclusion: Our findings support previous observations of more severe food reactions in people with asthma and that most FHS reported by this sample started after age 15. We found no evidence of changes in the prevalence of sensitization to food in adults followed for 10 years.
dc.format.extent 8
dc.format.extent 833-840
dc.language.iso en
dc.relation.ispartofseries European Journal of Clinical Nutrition; 77(8)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Barnalæknisfræði
dc.subject Adult
dc.subject Humans
dc.subject Adolescent
dc.subject Prevalence
dc.subject Food Hypersensitivity/epidemiology
dc.subject Hypersensitivity
dc.subject Food
dc.subject Allergens
dc.subject Asthma
dc.subject Immunoglobulin E
dc.subject Nutrition and Dietetics
dc.subject Medicine (miscellaneous)
dc.title Food hypersensitivity : an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36964270
dc.identifier.doi https://doi.org/10.1038/s41430-023-01284-w
dc.relation.url http://www.scopus.com/inward/record.url?scp=85150632974&partnerID=8YFLogxK
dc.contributor.department Other departments

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