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Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis

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dc.contributor.author Guðmundsdóttir, Judith Amalía
dc.contributor.author Thorgeirsdottir, Sigridur
dc.contributor.author Lundbäck, Veroniqa
dc.contributor.author Göngrich, Christina
dc.contributor.author Lingman Framme, Jenny
dc.contributor.author Kindgren, Erik
dc.contributor.author Rydenman, Karin
dc.contributor.author Lúðvíksson, Björn Rúnar
dc.contributor.author Bjarnadóttir, Helga
dc.contributor.author Runarsdottir, Saga
dc.contributor.author Nilsson, Staffan
dc.contributor.author Zetterström, Rolf H.
dc.contributor.author Ekwall, Olov
dc.contributor.author Lindgren, Susanne
dc.date.accessioned 2023-04-05T01:04:57Z
dc.date.available 2023-04-05T01:04:57Z
dc.date.issued 2023-04
dc.identifier.citation Guðmundsdóttir , J A , Thorgeirsdottir , S , Lundbäck , V , Göngrich , C , Lingman Framme , J , Kindgren , E , Rydenman , K , Lúðvíksson , B R , Bjarnadóttir , H , Runarsdottir , S , Nilsson , S , Zetterström , R H , Ekwall , O & Lindgren , S 2023 , ' Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis ' , Clinical Immunology , vol. 249 , 109277 , pp. 109277 . https://doi.org/10.1016/j.clim.2023.109277
dc.identifier.issn 1521-6616
dc.identifier.other PURE: 113527233
dc.identifier.other PURE UUID: 3d15f131-a97d-4ae7-8760-2198b03acd7e
dc.identifier.other Scopus: 85150860941
dc.identifier.uri https://hdl.handle.net/20.500.11815/4133
dc.description Funding Information: This work was supported by The Icelandic Society of Rheumatology , The Department of Pediatrics at the University of Gothenburg , Queen Silvia Children's Hospital Research Fund , The Gothenburg Society of Medicine , The Swedish Society of Medicine , The Swedish Rheumatism Association , Region Västra Götaland and The Swedish Research Council ( 2018-02752 ). Publisher Copyright: © 2023 The Authors Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
dc.description.abstract Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T- and B-cell output at birth, in patients with early onset JIA. Methods: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2–5 days after birth, in 156 children with early onset JIA and in 312 matched controls. Results: When analysed from neonatal dried blood spots, the median TREC level was 78 (IQR 55–113) in JIA cases and 88 (IQR 57–117) copies/well in controls. The median KREC level was 51 (IQR 35–69) and 53 (IQR 35–74) copies/well, in JIA cases and controls, respectively. Stratification by sex and age at disease onset did not reveal any difference in the levels of TRECs and KRECs. Conclusion: T- and B-cell output at birth, as measured by TREC and KREC levels in neonatal dried blood spots, does not differ in children with early onset JIA compared to controls.
dc.format.extent 109277
dc.language.iso en
dc.relation.ispartofseries Clinical Immunology; 249()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Ónæmisfræði
dc.subject Barnalæknisfræði
dc.subject Arthritis, juvenile
dc.subject Autoimmunity
dc.subject B lymphocytes
dc.subject Central tolerance
dc.subject Infant, newborn
dc.subject T lymphocytes
dc.subject T-cell receptor
dc.subject Thymus Gland
dc.subject T-Lymphocytes
dc.subject Humans
dc.subject B-Lymphocytes
dc.subject Receptors, Antigen, T-Cell
dc.subject Neonatal Screening
dc.subject Arthritis, Juvenile
dc.subject DNA
dc.subject Child
dc.subject Infant, Newborn
dc.subject Immunology and Allergy
dc.subject Immunology
dc.title Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36878420
dc.identifier.doi https://doi.org/10.1016/j.clim.2023.109277
dc.relation.url http://www.scopus.com/inward/record.url?scp=85150860941&partnerID=8YFLogxK
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine

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