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Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice

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dc.contributor.author Ásbjörnsdóttir, Birna Guðrún
dc.contributor.author Miranda-Ribera, Alba
dc.contributor.author Fiorentino, Maria
dc.contributor.author Konno, Takumi
dc.contributor.author Cetinbas, Murat
dc.contributor.author Lan, Jinggang
dc.contributor.author Sadreyev, Ruslan I.
dc.contributor.author Guðmundsson, Lárus Steinþór
dc.contributor.author Gottfreðsson, Magnús
dc.contributor.author Lauth, Bertrand Andre Marc
dc.contributor.author Birgisdóttir, Bryndís Eva
dc.contributor.author Fasano, Alessio
dc.date.accessioned 2023-03-31T01:06:11Z
dc.date.available 2023-03-31T01:06:11Z
dc.date.issued 2023
dc.identifier.citation Ásbjörnsdóttir , B G , Miranda-Ribera , A , Fiorentino , M , Konno , T , Cetinbas , M , Lan , J , Sadreyev , R I , Guðmundsson , L S , Gottfreðsson , M , Lauth , B A M , Birgisdóttir , B E & Fasano , A 2023 , ' Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice ' , Biomedicines , vol. 11 , no. 1 , 91 . https://doi.org/10.3390/biomedicines11010091
dc.identifier.issn 2227-9059
dc.identifier.other PURE: 86814982
dc.identifier.other PURE UUID: 8a50ad8a-59de-41c1-ab18-80656388e9f1
dc.identifier.other Scopus: 85146784130
dc.identifier.other unpaywall: 10.3390/biomedicines11010091
dc.identifier.uri https://hdl.handle.net/20.500.11815/4119
dc.description Funding Information: This research was partly supported by the Spector Family Foundation to M.F.; the MGH ECOR Feasibility Grant to A.M.R.; European Commission, award number 825033 “GEMMA project” funded on Horizon 2020 program (call H2020-SC1-BHC -03-2018) to A.F.; the Fulbright Foundation, the Leifur Eiríksson Foundation, University of Iceland Research Fund, and the Nutricia Research Foundation to B.A.; the Uehara Memorial Foundation Overseas Postdoctoral Fellowships and the Ito Foundation for the Promotion of Medical Science Travel Grants for Overseas Exchange to T.K. Publisher Copyright: © 2022 by the authors.
dc.description.abstract The microbiota–gut–brain axis (MGBA) involves bidirectional communication between intestinal microbiota and the gastrointestinal (GI) tract, central nervous system (CNS), neuroendocrine/neuroimmune systems, hypothalamic–pituitary–adrenal (HPA) axis, and enteric nervous system (ENS). The intestinal microbiota can influence host physiology and pathology. Dysbiosis involves the loss of beneficial microbial input or signal, diversity, and expansion of pathobionts, which can lead to loss of barrier function and increased intestinal permeability (IP). Colostrum, the first milk from mammals after birth, is a natural source of nutrients and is rich in oligosaccharides, immunoglobulins, growth factors, and anti-microbial components. The aim of this study was to investigate if bovine colostrum (BC) administration might modulate intestinal microbiota and, in turn, behavior in two mouse models, wild-type (WT) and Zonulin transgenic (Ztm)—the latter of which is characterized by dysbiotic microbiota, increased intestinal permeability, and mild hyperactivity—and to compare with control mice. Bioinformatics analysis of the microbiome showed that consumption of BC was associated with increased taxonomy abundance (p = 0.001) and diversity (p = 0.004) of potentially beneficial species in WT mice and shifted dysbiotic microbial community towards eubiosis in Ztm mice (p = 0.001). BC induced an anxiolytic effect in WT female mice compared with WT female control mice (p = 0.0003), and it reduced anxiogenic behavior in Ztm female mice compared with WT female control mice (p = 0.001), as well as in Ztm male mice compared with WT BC male mice (p = 0.03). As evidenced in MGBA interactions, BC supplementation may well be applied for prophylactic approaches in the future. Further research is needed to explore human interdependencies between intestinal microbiota, including eubiosis and pathobionts, and neuroinflammation, and the potential value of BC for human use. The MGH Institutional Animal Care and Use Committee authorized the animal study (2013N000013).
dc.language.iso en
dc.relation.ispartofseries Biomedicines; 11(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Smitsjúkdómalæknisfræði
dc.subject Barna- og unglingageðlæknisfræði
dc.subject anxiolytic effect
dc.subject bovine colostrum
dc.subject dysbiosis
dc.subject eubiosis
dc.subject mental disorders
dc.subject microbiota–gut–brain axis
dc.subject neuroinflammation
dc.subject oligosaccharide
dc.subject short-chain fatty acids
dc.subject zonulin
dc.subject Medicine (miscellaneous)
dc.subject Biochemistry, Genetics and Molecular Biology (all)
dc.title Prophylactic Effect of Bovine Colostrum on Intestinal Microbiota and Behavior in Wild-Type and Zonulin Transgenic Mice
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36672598
dc.identifier.doi https://doi.org/10.3390/biomedicines11010091
dc.relation.url http://www.scopus.com/inward/record.url?scp=85146784130&partnerID=8YFLogxK
dc.contributor.department Interdisciplinary Graduate Studies
dc.contributor.department Faculty of Pharmaceutical Sciences
dc.contributor.department Faculty of Medicine
dc.contributor.department Other departments
dc.contributor.department Women's and Childrens's Services
dc.contributor.department Faculty of Food Science and Nutrition

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