dc.contributor |
Landspitali - The National University Hospital of Iceland |
dc.contributor.author |
Egnell, Christina |
dc.contributor.author |
Heyman, Mats |
dc.contributor.author |
Jónsson, Ólafur Gísli |
dc.contributor.author |
Raja, Raheel A |
dc.contributor.author |
Niinimäki, Riitta |
dc.contributor.author |
Albertsen, Birgitte Klug |
dc.contributor.author |
Schmiegelow, Kjeld |
dc.contributor.author |
Stabell, Niklas |
dc.contributor.author |
Vaitkeviciene, Goda |
dc.contributor.author |
Lepik, Kristi |
dc.contributor.author |
Harila-Saari, Arja |
dc.contributor.author |
Ranta, Susanna |
dc.date.accessioned |
2023-03-29T01:04:21Z |
dc.date.available |
2023-03-29T01:04:21Z |
dc.date.issued |
2022-03 |
dc.identifier.citation |
Egnell , C , Heyman , M , Jónsson , Ó G , Raja , R A , Niinimäki , R , Albertsen , B K , Schmiegelow , K , Stabell , N , Vaitkeviciene , G , Lepik , K , Harila-Saari , A & Ranta , S 2022 , ' Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia. ' , British Journal of Haematology , vol. 196 , no. 5 , pp. 1239-1247 . https://doi.org/10.1111/bjh.17936 |
dc.identifier.issn |
0007-1048 |
dc.identifier.other |
48994161 |
dc.identifier.other |
445b20cf-f0cc-4fab-babc-725843746588 |
dc.identifier.other |
researchoutputwizard: hdl.handle.net/2336/622044 |
dc.identifier.other |
34726257 |
dc.identifier.other |
85118323533 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/4103 |
dc.description.abstract |
Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2·0-17·9 years with ALL treated with the Nordic Society of Pediatric Haematology and Oncology (NOPHO) ALL2008 non-high-risk protocol. Prospective treatment-related toxicities registered every three-month interval were used. Patients were classified according to sex- and age-adjusted international childhood cut-off values, corresponding to adult body mass index: underweight, <17 kg/m2 ; healthy weight, 17 to <25 kg/m2 ; overweight, 25 to <30 kg/m2 ; and obese, ≥30 kg/m2 . Obese children had a higher incidence rate ratio (IRR) for severe toxic events {IRR: 1·55 [95% confidence interval (CI) 1·07-2·50]}, liver and kidney failures, bleeding, abdominal complication, suspected unexpected severe adverse reactions and hyperlipidaemia compared with healthy-weight children. Obese children aged ≥10 years had increased IRRs for asparaginase-related toxicities compared with healthy-weight older children: thromboses [IRR 2·87 (95% CI 1·00-8·21)] and anaphylactic reactions [IRR 7·95 (95% CI 2·15-29·37)] as well as higher risk for truncation of asparaginase [IRR 3·54 (95% CI 1·67-7·50)]. The high prevalence of toxicity and a higher risk of truncation of asparaginase may play a role in the poor prognosis of obese children aged ≥10 years with ALL. |
dc.format.extent |
9 |
dc.format.extent |
405805 |
dc.format.extent |
1239-1247 |
dc.language.iso |
en |
dc.relation.ispartofseries |
British Journal of Haematology; 196(5) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Barnalæknisfræði |
dc.subject |
adverse events |
dc.subject |
body mass index |
dc.subject |
childhood acute lymphoblastic leukaemia |
dc.subject |
obesity |
dc.subject |
toxicity |
dc.subject |
adverse events |
dc.subject |
body mass index |
dc.subject |
childhood acute lymphoblastic leukaemia |
dc.subject |
obesity |
dc.subject |
toxicity |
dc.title |
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia. |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1111/bjh.17936 |
dc.relation.url |
https://onlinelibrary.wiley.com/doi/10.1111/bjh.17936 |