Opin vísindi

Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study) : A protocol for an observational longitudinal case-control study

Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study) : A protocol for an observational longitudinal case-control study


Title: Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study) : A protocol for an observational longitudinal case-control study
Author: Asbjornsdottir, Birna
Lauth, Bertrand
Fasano, Alessio   orcid.org/0000-0002-2134-0261
Thorsdottir, Inga
Karlsdottir, Ingibjorg
Gudmundsson, Larus S.
Gottfredsson, Magnus   orcid.org/0000-0003-2465-0422
Smarason, Orri
Sigurðardóttir, Sigurveig Þ
Halldorsson, Thorhallur I.
... 3 more authors Show all authors
Date: 2022-09-01
Language: English
Scope: e0273855
University/Institute: University of Iceland
Department: Faculty of Medicine
Women's and Childrens's Services
Faculty of Food Science and Nutrition
Other departments
Faculty of Pharmaceutical Sciences
Faculty of Psychology
Series: PLoS ONE; 17(9 September)
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0273855
Subject: Barna- og unglingageðlæknisfræði; Næringarfræðingar; Smitsjúkdómalæknisfræði; Ónæmisfræði; Adolescent; Case-Control Studies; Child; Gastrointestinal Microbiome/genetics; Humans; Meals; Mental Health; Observational Studies as Topic; RNA, Ribosomal, 16S/genetics
URI: https://hdl.handle.net/20.500.11815/4083

Show full item record

Citation:

Asbjornsdottir , B , Lauth , B , Fasano , A , Thorsdottir , I , Karlsdottir , I , Gudmundsson , L S , Gottfredsson , M , Smarason , O , Sigurðardóttir , S Þ , Halldorsson , T I , Marteinsson , V T , Gudmundsdottir , V & Birgisdottir , B E 2022 , ' Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study) : A protocol for an observational longitudinal case-control study ' , PLoS ONE , vol. 17 , no. 9 September , e0273855 , pp. e0273855 . https://doi.org/10.1371/journal.pone.0273855

Abstract:

Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability can impact mental health. More than 10% of children and adolescents in Iceland suffer from mental disorders, and rates of psychotropics use are very high. The aim of this novel observational longitudinal case-control study, “Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study)” is to contribute to the promotion of treatment options for children and adolescents diagnosed with mental disorders through identification of patterns that may affect the symptoms. All children and adolescents, 5-15 years referred to the outpatient clinic of the Child and Adolescent Psychiatry Department at The National University Hospital in Reykjavik, Iceland, for one year (n≈150) will be invited to participate. There are two control groups, i.e., sex-matched children from the same postal area (n≈150) and same parent siblings (full siblings) in the same household close in age +/- 3 years (n<150). A three-day food diary, rating scales for mental health, and multiple questionnaires will be completed. Biosamples (fecal-, urine-, saliva-, blood samples, and buccal swab) will be collected and used for 16S rRNA gene amplicon sequencing of the oral and gut microbiome, measurements of serum factors, quantification of urine metabolites and host genotype, respectively. For longitudinal follow-up, data collection will be repeated after three years in the same groups. Integrative analysis of diet, gut microbiota, intestinal permeability, serum metabolites, and mental health will be conducted applying bioinformatics and systems biology approaches. Extensive population-based data of this quality has not been collected before, with collection repeated in three years' time, contributing to the high scientific value. The MMM-study follows the “Strengthening the Reporting of Observational Studies in Epidemiology” (STROBE) guidelines. Approval has been obtained from the Icelandic National Bioethics Committee, and the study is registered with Clinicaltrials.gov. The study will contribute to an improved understanding of the links between diet, gut microbiota and mental health in children through good quality study design by collecting information on multiple components, and a longitudinal approach. Furthermore, the study creates knowledge on possibilities for targeted and more personalized dietary and lifestyle interventions in subgroups.

Description:

Funding Information: This manuscript was partially funded by grant European Union's Horizon 2020 research and innovation program, grant GEMMA 825033 as well as by the University of Iceland Research Fund and The Landspitali University Hospital Scientific Fund. Publisher Copyright: © 2022 Asbjornsdottir et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Files in this item

This item appears in the following Collection(s)