Opin vísindi

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Show simple item record

dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Forzano, Francesca
dc.contributor.author Antonova, Olga
dc.contributor.author Clarke, Angus
dc.contributor.author de Wert, Guido
dc.contributor.author Hentze, Sabine
dc.contributor.author Jamshidi, Yalda
dc.contributor.author Moreau, Yves
dc.contributor.author Perola, Markus
dc.contributor.author Prokopenko, Inga
dc.contributor.author Read, Andrew
dc.contributor.author Reymond, Alexandre
dc.contributor.author Stefánsdóttir, Vigdís Fjóla
dc.contributor.author van El, Carla
dc.contributor.author Genuardi, Maurizio
dc.contributor.author Peterlin, Borut
dc.contributor.author Oliveira, Carla
dc.contributor.author Writzl, Karin
dc.contributor.author Houge, Gunnar Douzgos
dc.contributor.author Cordier, Christophe
dc.contributor.author Howard, Heidi
dc.contributor.author Macek, Milan
dc.contributor.author Melegh, Béla
dc.contributor.author Mendes, Alvaro
dc.contributor.author Radojkovic, Dragica
dc.contributor.author Rial-Sebbag, Emmanuelle
dc.contributor.author Ulph, Fiona
dc.contributor.author Jamshidi, Yalda
dc.date.accessioned 2023-03-18T01:02:25Z
dc.date.available 2023-03-18T01:02:25Z
dc.date.issued 2021-12-17
dc.identifier.citation Forzano , F , Antonova , O , Clarke , A , de Wert , G , Hentze , S , Jamshidi , Y , Moreau , Y , Perola , M , Prokopenko , I , Read , A , Reymond , A , Stefánsdóttir , V F , van El , C , Genuardi , M , Peterlin , B , Oliveira , C , Writzl , K , Houge , G D , Cordier , C , Howard , H , Macek , M , Melegh , B , Mendes , A , Radojkovic , D , Rial-Sebbag , E , Ulph , F & Jamshidi , Y 2021 , ' The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice ' , European Journal of Human Genetics . https://doi.org/10.1038/s41431-021-01000-x
dc.identifier.issn 1018-4813
dc.identifier.other PURE: 48992405
dc.identifier.other PURE UUID: 7a5bd8d4-55f0-4236-9458-fad0a585086f
dc.identifier.other researchoutputwizard: hdl.handle.net/2336/622076
dc.identifier.other Scopus: 85121535929
dc.identifier.uri https://hdl.handle.net/20.500.11815/4079
dc.description.abstract Y Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
dc.language.iso en
dc.relation.ispartofseries European Journal of Human Genetics; ()
dc.rights info:eu-repo/semantics/openAccess
dc.subject Náttúrufræðingar
dc.subject Genetics (clinical)
dc.subject Genetics
dc.subject Erfðarannsóknir
dc.subject Genetics (clinical)
dc.subject Genetics
dc.subject Erfðarannsóknir
dc.title The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Non peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41431-021-01000-x
dc.relation.url https://www.nature.com/articles/s41431-021-01000-x
dc.contributor.department Other departments

Files in this item

This item appears in the following Collection(s)

Show simple item record