dc.contributor | Landspitali - The National University Hospital of Iceland |
dc.contributor.author | Moitra, Subhabrata |
dc.contributor.author | Carsin, Anne Elie |
dc.contributor.author | Abramson, Michael J. |
dc.contributor.author | Accordini, Simone |
dc.contributor.author | Amaral, Andre F.S. |
dc.contributor.author | Anto, Josep |
dc.contributor.author | Bono, Roberto |
dc.contributor.author | Casas Ruiz, Lidia |
dc.contributor.author | Cerveri, Isa |
dc.contributor.author | Chatzi, Leda |
dc.contributor.author | Demoly, Pascal |
dc.contributor.author | Dorado-Arenas, Sandra |
dc.contributor.author | Forsberg, Bertil |
dc.contributor.author | Gilliland, Frank |
dc.contributor.author | Gíslason, Þórarinn |
dc.contributor.author | Gullón, Jose A. |
dc.contributor.author | Heinrich, Joachim |
dc.contributor.author | Holm, Mathias |
dc.contributor.author | Janson, Christer |
dc.contributor.author | Jogi, Rain |
dc.contributor.author | Gómez Real, Francisco |
dc.contributor.author | Jarvis, Debbie |
dc.contributor.author | Leynaert, Bénédicte |
dc.contributor.author | Nowak, Dennis |
dc.contributor.author | Probst-Hensch, Nicole |
dc.contributor.author | Sánchez-Ramos, José Luis |
dc.contributor.author | Raherison-Semjen, Chantal |
dc.contributor.author | Siroux, Valerie |
dc.contributor.author | Guerra, Stefano |
dc.contributor.author | Kogevinas, Manolis |
dc.contributor.author | Garcia-Aymerich, Judith |
dc.date.accessioned | 2023-03-15T01:02:51Z |
dc.date.available | 2023-03-15T01:02:51Z |
dc.date.issued | 2023-02 |
dc.identifier.citation | Moitra , S , Carsin , A E , Abramson , M J , Accordini , S , Amaral , A F S , Anto , J , Bono , R , Casas Ruiz , L , Cerveri , I , Chatzi , L , Demoly , P , Dorado-Arenas , S , Forsberg , B , Gilliland , F , Gíslason , Þ , Gullón , J A , Heinrich , J , Holm , M , Janson , C , Jogi , R , Gómez Real , F , Jarvis , D , Leynaert , B , Nowak , D , Probst-Hensch , N , Sánchez-Ramos , J L , Raherison-Semjen , C , Siroux , V , Guerra , S , Kogevinas , M & Garcia-Aymerich , J 2023 , ' Long-term effect of asthma on the development of obesity among adults : an international cohort study, ECRHS ' , Thorax , vol. 78 , no. 2 , 217867 , pp. 128-135 . https://doi.org/10.1136/thoraxjnl-2021-217867 |
dc.identifier.issn | 0040-6376 |
dc.identifier.other | 56807334 |
dc.identifier.other | 1b7fa7a8-de99-48f1-904d-bcd3e058ee5b |
dc.identifier.other | 85130828197 |
dc.identifier.other | 35477559 |
dc.identifier.other | unpaywall: 10.1136/thoraxjnl-2021-217867 |
dc.identifier.uri | https://hdl.handle.net/20.500.11815/4064 |
dc.description | Publisher Copyright: © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ. |
dc.description.abstract | Introduction: Obesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults. Methods: We used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m2) individuals at visit t. The relative risk (RR) of obesity at t+1 associated with asthma at t was estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity. Results: We included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II - III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association. Conclusion: This is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids. |
dc.format.extent | 8 |
dc.format.extent | 1232415 |
dc.format.extent | 128-135 |
dc.language.iso | en |
dc.relation.ispartofseries | Thorax; 78(2) |
dc.rights | info:eu-repo/semantics/restrictedAccess |
dc.subject | Lungnalæknisfræði |
dc.subject | Asthma |
dc.subject | Asthma Epidemiology |
dc.subject | Clinical Epidemiology |
dc.subject | Obesity |
dc.subject | Pediatric Obesity/complications |
dc.subject | Adrenal Cortex Hormones |
dc.subject | Humans |
dc.subject | Male |
dc.subject | Health Surveys |
dc.subject | European Union |
dc.subject | Adult |
dc.subject | Female |
dc.subject | Asthma/epidemiology |
dc.subject | Child |
dc.subject | Cohort Studies |
dc.subject | Pulmonary and Respiratory Medicine |
dc.title | Long-term effect of asthma on the development of obesity among adults : an international cohort study, ECRHS |
dc.type | /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version | Peer reviewed |
dc.identifier.doi | 10.1136/thoraxjnl-2021-217867 |
dc.relation.url | http://www.scopus.com/inward/record.url?scp=85130828197&partnerID=8YFLogxK |
dc.contributor.department | Internal Medicine and Emergency Services |