Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

Van Zuydam, Natalie R.; Ladenvall, Claes; Voight, Benjamin F.; Strawbridge, Rona J.; Fernandez-Tajes, Juan; Rayner, N. William; Robertson, Neil R.; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E.; Nelson, Christopher P.; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; Song, Ci; Hartiala, Jaana A.; Pedersen, Nancy L.; Perola, Markus; Gieger, Christian; Peters, Annette; Qu, Liming; Willems, Sara M.; Doney, Alex S.F.; Morris, Andrew D.; Zheng, Yan; Sesti, Giorgio; Hu, Frank B.; Qi, Lu; Laakso, Markku; Thorsteinsdottir, Unnur; Grallert, Harald; Van Duijn, Cornelia; Reilly, Muredach P.; Ingelsson, Erik; Deloukas, Panos; Kathiresan, Sek; Metspalu, Andres; Shah, Svati H.; Sinisalo, Juha; Salomaa, Veikko; Hamsten, Anders; Samani, Nilesh J.; März, Winfried; Hazen, Stanley L.

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dc.contributor.author	Van Zuydam, Natalie R.
dc.contributor.author	Ladenvall, Claes
dc.contributor.author	Voight, Benjamin F.
dc.contributor.author	Strawbridge, Rona J.
dc.contributor.author	Fernandez-Tajes, Juan
dc.contributor.author	Rayner, N. William
dc.contributor.author	Robertson, Neil R.
dc.contributor.author	Mahajan, Anubha
dc.contributor.author	Vlachopoulou, Efthymia
dc.contributor.author	Goel, Anuj
dc.contributor.author	Kleber, Marcus E.
dc.contributor.author	Nelson, Christopher P.
dc.contributor.author	Kwee, Lydia Coulter
dc.contributor.author	Esko, Tõnu
dc.contributor.author	Mihailov, Evelin
dc.contributor.author	Mägi, Reedik
dc.contributor.author	Milani, Lili
dc.contributor.author	Fischer, Krista
dc.contributor.author	Kanoni, Stavroula
dc.contributor.author	Kumar, Jitender
dc.contributor.author	Song, Ci
dc.contributor.author	Hartiala, Jaana A.
dc.contributor.author	Pedersen, Nancy L.
dc.contributor.author	Perola, Markus
dc.contributor.author	Gieger, Christian
dc.contributor.author	Peters, Annette
dc.contributor.author	Qu, Liming
dc.contributor.author	Willems, Sara M.
dc.contributor.author	Doney, Alex S.F.
dc.contributor.author	Morris, Andrew D.
dc.contributor.author	Zheng, Yan
dc.contributor.author	Sesti, Giorgio
dc.contributor.author	Hu, Frank B.
dc.contributor.author	Qi, Lu
dc.contributor.author	Laakso, Markku
dc.contributor.author	Thorsteinsdottir, Unnur
dc.contributor.author	Grallert, Harald
dc.contributor.author	Van Duijn, Cornelia
dc.contributor.author	Reilly, Muredach P.
dc.contributor.author	Ingelsson, Erik
dc.contributor.author	Deloukas, Panos
dc.contributor.author	Kathiresan, Sek
dc.contributor.author	Metspalu, Andres
dc.contributor.author	Shah, Svati H.
dc.contributor.author	Sinisalo, Juha
dc.contributor.author	Salomaa, Veikko
dc.contributor.author	Hamsten, Anders
dc.contributor.author	Samani, Nilesh J.
dc.contributor.author	März, Winfried
dc.contributor.author	Hazen, Stanley L.
dc.date.accessioned	2023-02-25T01:05:53Z
dc.date.available	2023-02-25T01:05:53Z
dc.date.issued	2020-12-01
dc.identifier.citation	Van Zuydam , N R , Ladenvall , C , Voight , B F , Strawbridge , R J , Fernandez-Tajes , J , Rayner , N W , Robertson , N R , Mahajan , A , Vlachopoulou , E , Goel , A , Kleber , M E , Nelson , C P , Kwee , L C , Esko , T , Mihailov , E , Mägi , R , Milani , L , Fischer , K , Kanoni , S , Kumar , J , Song , C , Hartiala , J A , Pedersen , N L , Perola , M , Gieger , C , Peters , A , Qu , L , Willems , S M , Doney , A S F , Morris , A D , Zheng , Y , Sesti , G , Hu , F B , Qi , L , Laakso , M , Thorsteinsdottir , U , Grallert , H , Van Duijn , C , Reilly , M P , Ingelsson , E , Deloukas , P , Kathiresan , S , Metspalu , A , Shah , S H , Sinisalo , J , Salomaa , V , Hamsten , A , Samani , N J , März , W & Hazen , S L 2020 , ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ' , Circulation: Genomic and Precision Medicine , vol. 13 , no. 6 , pp. E002769 . https://doi.org/10.1161/CIRCGEN.119.002769
dc.identifier.issn	1942-325X
dc.identifier.other	69288467
dc.identifier.other	cdbfd4d3-dd54-48d8-b18e-3d28610e867c
dc.identifier.other	85097959733
dc.identifier.other	33321069
dc.identifier.uri	https://hdl.handle.net/20.500.11815/4032
dc.description	This work was supported by the European Union Framework Programme 7 (FP7/2007-2013) for the Innovative Medicine Initiative (IMI) under grant agreement n° IMI/115006 (the SUMMIT [Surrogate Markers for Micro- and Macro-Vascular Hard End Points for Innovative Diabetes Tools] consortium); Aarno Koskelo Foundation; Academy of Finland (no. 263401; no. 2676882); American Heart Association (13SDG14330006); AstraZeneca; AtheroSysMed (Systems medicine of coronary heart disease and stroke); British Heart Foundation Centre of Research Excellence at Oxford; ERC269045-Gene Target T2D grant; Estonian Research Council (IUT20-60, PUT1660 and PUT1665P); Estonian Center of Genomics/Roadmap II (project No. 2014-2020.4.01.16-0125); European Union (no. 692145; no. 633589; no. 313010; LSHM-CT-2007-037273; no. 201668; 2014-2020.4.01.15-0012;QLG1-CT-2002-00896; EU/QLRT-2001-01254; QLG2-CT-2002-01254 HEALTH-F2-2013-601456); Finnish Foundation for Cardiovascular research; Gentransmed - Centre of Excellence for Genomics and Translational Medicine; German Ministry of Education and Research (no. 01ZX1313A-K); Helsinki University Central Hospital special government funds (TYH7215, TKK2012005, TYH2012209, TYH2014312); Juvenile Diabetes Research Foundation (JDRF, 2-SRA-2014-276-Q-R); National Institute of Diabetes and Digestive and Kidney diseases (NIDDK, 5R01DK106236; U01-DK066134; U01-DK105535; R01DK101478); National Heart, Lung and Blood Institute (NLHBI, R01HL103866); National Institute for Health Research (NIHR); Personalized diagnostics and treatment of high risk coronary artery disease patients (RiskyCAD; 305739); Sigrid Juselius Foundation; Finnish Academy (no. 269517); Finnish Foundation for Cardiovascular Research; Foundation for Strategic Research and Stockholm County Council (560283; 592229); Juho Vainio Foundation; Knut and Alice Wallenberg Foundation; Ministry for Higher Education; Strategic Cardiovascular and Diabetes Programmes of Karolinska Institutet and Stockholm County Council; Swedish Foundation for Strategic Research (SSF; ICA08-0047); Swedish Heart-Lung Foundation; Swedish Research Council (project 8691; 2015-02558; 2016-00598; M-2005-1112 and 2009-2298); Torsten and Ragnar Söderberg Foundation; W.W. Smith Charitable Trust (H1201); Wellcome Trust Institutional strategic support fund; Yrjö Jahnsson Foundation. Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved.
dc.description.abstract	Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
dc.format.extent	1659446
dc.format.extent	E002769
dc.language.iso	en
dc.relation	info:eu-repo/grantAgreement/EC/FP7/115006
dc.relation.ispartofseries	Circulation: Genomic and Precision Medicine; 13(6)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	blood pressure
dc.subject	coronary artery disease
dc.subject	diabetes mellitus
dc.subject	genome-wide association study
dc.subject	risk factors
dc.subject	Genetics
dc.subject	Cardiology and Cardiovascular Medicine
dc.subject	Genetics (clinical)
dc.title	Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
dc.type	/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version	Peer reviewed
dc.identifier.doi	10.1161/CIRCGEN.119.002769
dc.relation.url	http://www.scopus.com/inward/record.url?scp=85097959733&partnerID=8YFLogxK
dc.contributor.school	Health Sciences