Opin vísindi

Clinical Remission of Asthma and Allergic Rhinitis-in a Longitudinal Population Study

Clinical Remission of Asthma and Allergic Rhinitis-in a Longitudinal Population Study

Title: Clinical Remission of Asthma and Allergic Rhinitis-in a Longitudinal Population Study
Author: Heldin, Johanna
Malinovschi, Andrei
Johannessen, Ane
Alving, Kjell
Holm, Mathias
Franklin, Karl A.
Forsberg, Bertil
Schlünssen, Vivi
Jögi, Rain
Gíslason, Þórarinn
... 3 more authors Show all authors
Date: 2022
Language: English
Scope: 10
School: Health Sciences
Department: Faculty of Medicine
Internal Medicine and Emergency Services
Series: Journal of Asthma and Allergy; 15()
ISSN: 1178-6965
DOI: 10.2147/JAA.S378584
Subject: Lungnalæknisfræði; allergic rhinitis; asthma; epidemiology; remission; Immunology and Allergy; Pulmonary and Respiratory Medicine
URI: https://hdl.handle.net/20.500.11815/3941

Show full item record


Heldin , J , Malinovschi , A , Johannessen , A , Alving , K , Holm , M , Franklin , K A , Forsberg , B , Schlünssen , V , Jögi , R , Gíslason , Þ , Benediktsdóttir , B , Svanes , C & Janson , C 2022 , ' Clinical Remission of Asthma and Allergic Rhinitis-in a Longitudinal Population Study ' , Journal of Asthma and Allergy , vol. 15 , pp. 1569-1578 . https://doi.org/10.2147/JAA.S378584


Background: Although asthma and allergic rhinitis are chronic diseases, some patients experience periods of remission. Information on prognostic factors associated with the remission of asthma and allergic rhinitis is valuable in resource prioritization. This study investigated factors associated with the clinical remission of asthma and allergic rhinitis. Methods: In the Respiratory Health In Northern Europe (RHINE) study, data was collected with questionnaires in stage one (RHINE I, 1989–1992) and two follow-ups (RHINE II, 1999–2001 and RHINE III, 2010–2012) from Sweden, Norway, Denmark, Iceland and Estonia. Clinical remission was defined as having reported asthma or allergic rhinitis in RHINE I or RHINE II but not in RHINE III. Results: Of 13,052 participants, 975 (7.5%) reported asthma in RHINE I or RHINE II, and 3379 (25.9%) allergic rhinitis. Clinical remission of asthma and allergic rhinitis was found in 46.4% and 31.8%, respectively. Living in Estonia (OR (95% CI) 2.44 (1.22– 4.85)) and living in an apartment (1.45 (1.06–1.98)) were related to remission of asthma, while subjects reporting allergic rhinitis (0.68 (0.51–0.90)), asthma onset ≤ 12 years of age (0.49 (0.35–0.68)), receiving treatment with antibiotics for respiratory illness (0.64 (0.47– 0.87)) were less likely to have asthma remission. Factors related to a higher likelihood of remission of allergic rhinitis were no asthma at baseline, age ≥ 58 years in RHINE III, allergic rhinitis onset after 12 years of age, living in rural areas as a child, having only a primary school education and not being pregnant. Conclusion: Clinical remission was found in almost one-half of those with asthma and one-third of persons with allergic rhinitis. Coexisting allergic symptoms were associated with less clinical asthma remission. Age, asthma symptoms and environmental factors in childhood, such as living in a rural area, were found to influence the clinical remission of allergic rhinitis.


Funding Information: JH was financed by a grant from the Swedish Society of Medicine. The RHINE study was funded by the Swedish Heart and Lung Foundation, the Swedish Association Against Asthma and Allergy, the Swedish Association against Heart and Lung Disease, the Swedish Council for Working Life and Social Research, the Bror Hjerpstedt Foundation, The Faculty of Health, Aarhus University, Denmark (Project No. 240008), The Wood Dust Foundation (Project No. 444508795), The Danish Lung Association, The Norwegian Research Council project 135773/330, The Norwegian Asthma and Allergy Association, The Icelandic Research Council and the Estonian Science Foundation (Grant No. 4350). Vivi Schlünssen, Thorarinn Gislason and Cecilie Svanes are members of the COST BM1201 network. Publisher Copyright: © 2022 Heldin et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

Files in this item

This item appears in the following Collection(s)