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Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Jónsson, Arnar Jan
dc.contributor.author Lund, Sigrún Helga
dc.contributor.author Eriksen, Bjorn O.
dc.contributor.author Pálsson, Runólfur
dc.contributor.author Indriðason, Ólafur Skúli
dc.date.accessioned 2023-01-28T01:03:42Z
dc.date.available 2023-01-28T01:03:42Z
dc.date.issued 2022-07-01
dc.identifier.citation Jónsson , A J , Lund , S H , Eriksen , B O , Pálsson , R & Indriðason , Ó S 2022 , ' Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland ' , Clinical Kidney Journal , vol. 15 , no. 7 , pp. 1290-1299 . https://doi.org/10.1093/ckj/sfac051
dc.identifier.issn 2048-8505
dc.identifier.other 48345823
dc.identifier.other ce1da904-098e-444b-8c2a-5d35ef187599
dc.identifier.other 000786294000001
dc.identifier.other 35756731
dc.identifier.other unpaywall: 10.1093/ckj/sfac051
dc.identifier.other 85142650005
dc.identifier.uri https://hdl.handle.net/20.500.11815/3912
dc.description Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA.
dc.description.abstract Background: Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1-5 in Iceland, based on multiple markers of kidney damage. Methods: All serum creatinine (SCr) values, urine protein measurements and diagnosis codes for kidney diseases and comorbid conditions for people aged ≥18 years were obtained from electronic medical records of all healthcare institutions in Iceland in 2008-2016. CKD was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria as evidence for kidney damage and/or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 for >3 months. Alternatively, CKD was defined using age-adapted eGFR thresholds. Mean annual age-standardized incidence of CKD was calculated for persons without CKD at study entry. Risk factor assessment was based on International Classification of Diseases diagnosis codes. Incidence was reported per 100 000 population. Results: We retrieved 1 820 990 SCr values for 206 727 persons. Median age was 45 years (range, 18-106) and 47% were men. Mean annual age-standardized incidence of CKD per 100 000 was 649 in men and 694 in women, and 480 in men and 522 in women using age-adapted eGFR thresholds. The incidence reached over 3000 in men and women aged >75 years. Traditional CKD risk factors, such as acute kidney injury, diabetes, hypertension and cardiovascular disease, as well as less well characterized risk factors, including chronic lung disease, malignancy and major psychiatric illness were associated with increased risk of CKD, and the same was true for obesity and sleep apnoea in women. Conclusion: The annual incidence of CKD, with strict adherence to the KDIGO criteria, was <0.7% but markedly lower using age-adapted eGFR thresholds. Apart from acute kidney injury, the observed risk factors comprised chronic and potentially modifiable disorders.
dc.format.extent 10
dc.format.extent 1072472
dc.format.extent 1290-1299
dc.language.iso en
dc.relation.ispartofseries Clinical Kidney Journal; 15(7)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Nýrnalæknisfræði
dc.subject Nýrnasjúkdómar
dc.subject chronic kidney disease
dc.subject eGFR
dc.subject incidence
dc.subject KDIGO criteria
dc.subject risk factors
dc.subject Nephrology
dc.subject Transplantation
dc.title Incidence of and risk factors of chronic kidney disease: results of a nationwide study in Iceland
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1093/ckj/sfac051
dc.relation.url http://www.scopus.com/inward/record.url?scp=85142650005&partnerID=8YFLogxK
dc.contributor.department Faculty of Physical Sciences
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine
dc.contributor.department Office of Division of Clinical Services I

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