dc.contributor.author |
Vogt, Elinor Chelsom |
dc.contributor.author |
Real, Francisco Gómez |
dc.contributor.author |
Husebye, Eystein Sverre |
dc.contributor.author |
Björnsdottir, Sigridur |
dc.contributor.author |
Benediktsdóttir, Bryndís |
dc.contributor.author |
Bertelsen, Randi Jacobsen |
dc.contributor.author |
Demoly, Pascal |
dc.contributor.author |
Franklin, Karl Anders |
dc.contributor.author |
Gallastegui, Leire Sainz de Aja |
dc.contributor.author |
González, Francisco Javier Callejas |
dc.contributor.author |
Heinrich, Joachim |
dc.contributor.author |
Holm, Mathias |
dc.contributor.author |
Jogi, Nils Oscar |
dc.contributor.author |
Leynaert, Benedicte |
dc.contributor.author |
Lindberg, Eva |
dc.contributor.author |
Malinovschi, Andrei |
dc.contributor.author |
Martínez-Moratalla, Jesús |
dc.contributor.author |
Mayoral, Raúl Godoy |
dc.contributor.author |
Oudin, Anna |
dc.contributor.author |
Pereira-Vega, Antonio |
dc.contributor.author |
Semjen, Chantal Raherison |
dc.contributor.author |
Schlünssen, Vivi |
dc.contributor.author |
Triebner, Kai |
dc.contributor.author |
Øksnes, Marianne |
dc.date.accessioned |
2023-01-26T01:04:16Z |
dc.date.available |
2023-01-26T01:04:16Z |
dc.date.issued |
2022-05 |
dc.identifier.citation |
Vogt , E C , Real , F G , Husebye , E S , Björnsdottir , S , Benediktsdóttir , B , Bertelsen , R J , Demoly , P , Franklin , K A , Gallastegui , L S D A , González , F J C , Heinrich , J , Holm , M , Jogi , N O , Leynaert , B , Lindberg , E , Malinovschi , A , Martínez-Moratalla , J , Mayoral , R G , Oudin , A , Pereira-Vega , A , Semjen , C R , Schlünssen , V , Triebner , K & Øksnes , M 2022 , ' Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts ' , Endocrine Connections , vol. 11 , no. 5 , e220024 . https://doi.org/10.1530/EC-22-0024 |
dc.identifier.issn |
2049-3614 |
dc.identifier.other |
79105115 |
dc.identifier.other |
650c6cad-92b4-4426-963d-4de3d048a028 |
dc.identifier.other |
85131700149 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/3903 |
dc.description |
Funding Information: The study was supported by grants and fellowships from Stiftelsen Kristian Gerhard Jebsen, The Norwegian Research Council, University of Bergen, and The Regional Health Authorities of Western Norway. Publisher Copyright: © 2022 The authors Published by Bioscientifica Ltd. |
dc.description.abstract |
Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women. Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI. Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63–3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin. Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies. |
dc.format.extent |
1246524 |
dc.format.extent |
|
dc.language.iso |
en |
dc.relation.ispartofseries |
Endocrine Connections; 11(5) |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Lungnalæknisfræði |
dc.subject |
autoimmune |
dc.subject |
premature menopause |
dc.subject |
premature ovarian failure |
dc.subject |
premature ovarian insufficiency |
dc.subject |
primary ovarian insufficiency |
dc.subject |
Internal Medicine |
dc.subject |
Endocrinology, Diabetes and Metabolism |
dc.subject |
Endocrinology |
dc.title |
Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts |
dc.type |
/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article |
dc.description.version |
Peer reviewed |
dc.identifier.doi |
10.1530/EC-22-0024 |
dc.relation.url |
http://www.scopus.com/inward/record.url?scp=85131700149&partnerID=8YFLogxK |
dc.contributor.department |
Other departments |
dc.contributor.school |
Health Sciences |