Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Lahti, Jari; Tuominen, Samuli; Yang, Qiong; Pergola, Giulio; Ahmad, Shahzad; Amin, Najaf; Armstrong, Nicola J.; Beiser, Alexa; Bey, Katharina; Bis, Joshua C.; Boerwinkle, Eric; Bressler, Jan; Campbell, Archie; Campbell, Harry; Chen, Qiang; Corley, Janie; Cox, Simon R.; Davies, Gail; De Jager, Philip L.; Derks, Eske M.; Faul, Jessica D.; Fitzpatrick, Annette L.; Fohner, Alison E.; Ford, Ian; Fornage, Myriam; Gerring, Zachary; Grabe, Hans J.; Grodstein, Francine; Gudnason, Vilmundur; Simonsick, Eleanor; Holliday, Elizabeth G.; Joshi, Peter K.; Kajantie, Eero; Kaprio, Jaakko; Karell, Pauliina; Kleineidam, Luca; Knol, Maria J.; Kochan, Nicole A.; Kwok, John B.; Leber, Markus; Lam, Max; Lee, Teresa; Li, Shuo; Loukola, Anu; Luck, Tobias; Marioni, Riccardo E.; Mather, Karen A.; Medland, Sarah; Mirza, Saira S.; Nalls, Mike A.

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dc.contributor.author	Lahti, Jari
dc.contributor.author	Tuominen, Samuli
dc.contributor.author	Yang, Qiong
dc.contributor.author	Pergola, Giulio
dc.contributor.author	Ahmad, Shahzad
dc.contributor.author	Amin, Najaf
dc.contributor.author	Armstrong, Nicola J.
dc.contributor.author	Beiser, Alexa
dc.contributor.author	Bey, Katharina
dc.contributor.author	Bis, Joshua C.
dc.contributor.author	Boerwinkle, Eric
dc.contributor.author	Bressler, Jan
dc.contributor.author	Campbell, Archie
dc.contributor.author	Campbell, Harry
dc.contributor.author	Chen, Qiang
dc.contributor.author	Corley, Janie
dc.contributor.author	Cox, Simon R.
dc.contributor.author	Davies, Gail
dc.contributor.author	De Jager, Philip L.
dc.contributor.author	Derks, Eske M.
dc.contributor.author	Faul, Jessica D.
dc.contributor.author	Fitzpatrick, Annette L.
dc.contributor.author	Fohner, Alison E.
dc.contributor.author	Ford, Ian
dc.contributor.author	Fornage, Myriam
dc.contributor.author	Gerring, Zachary
dc.contributor.author	Grabe, Hans J.
dc.contributor.author	Grodstein, Francine
dc.contributor.author	orcid.org/0000-0001-5696-0084 Gudnason, Vilmundur
dc.contributor.author	Simonsick, Eleanor
dc.contributor.author	Holliday, Elizabeth G.
dc.contributor.author	Joshi, Peter K.
dc.contributor.author	Kajantie, Eero
dc.contributor.author	Kaprio, Jaakko
dc.contributor.author	Karell, Pauliina
dc.contributor.author	Kleineidam, Luca
dc.contributor.author	Knol, Maria J.
dc.contributor.author	Kochan, Nicole A.
dc.contributor.author	Kwok, John B.
dc.contributor.author	Leber, Markus
dc.contributor.author	Lam, Max
dc.contributor.author	Lee, Teresa
dc.contributor.author	Li, Shuo
dc.contributor.author	Loukola, Anu
dc.contributor.author	Luck, Tobias
dc.contributor.author	Marioni, Riccardo E.
dc.contributor.author	Mather, Karen A.
dc.contributor.author	Medland, Sarah
dc.contributor.author	Mirza, Saira S.
dc.contributor.author	Nalls, Mike A.
dc.date.accessioned	2023-01-21T01:06:02Z
dc.date.available	2023-01-21T01:06:02Z
dc.date.issued	2022-08-16
dc.identifier.citation	Lahti , J , Tuominen , S , Yang , Q , Pergola , G , Ahmad , S , Amin , N , Armstrong , N J , Beiser , A , Bey , K , Bis , J C , Boerwinkle , E , Bressler , J , Campbell , A , Campbell , H , Chen , Q , Corley , J , Cox , S R , Davies , G , De Jager , P L , Derks , E M , Faul , J D , Fitzpatrick , A L , Fohner , A E , Ford , I , Fornage , M , Gerring , Z , Grabe , H J , Grodstein , F , Gudnason , V , Simonsick , E , Holliday , E G , Joshi , P K , Kajantie , E , Kaprio , J , Karell , P , Kleineidam , L , Knol , M J , Kochan , N A , Kwok , J B , Leber , M , Lam , M , Lee , T , Li , S , Loukola , A , Luck , T , Marioni , R E , Mather , K A , Medland , S , Mirza , S S & Nalls , M A 2022 , ' Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning ' , Molecular Psychiatry , vol. 27 , no. 11 , pp. 4419-4431 . https://doi.org/10.1038/s41380-022-01710-8
dc.identifier.issn	1359-4184
dc.identifier.other	70306901
dc.identifier.other	f89f9261-9d8d-43b2-a3fd-b5759f8f0a04
dc.identifier.other	85136173551
dc.identifier.other	35974141
dc.identifier.other	unpaywall: 10.1038/s41380-022-01710-8
dc.identifier.uri	https://hdl.handle.net/20.500.11815/3865
dc.description	Publisher Copyright: © 2022, The Author(s).
dc.description.abstract	Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
dc.format.extent	13
dc.format.extent	3641305
dc.format.extent	4419-4431
dc.language.iso	en
dc.relation.ispartofseries	Molecular Psychiatry; 27(11)
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Memory, Short-Term/physiology
dc.subject	Learning
dc.subject	Verbal Learning
dc.subject	Multifactorial Inheritance
dc.subject	Brain
dc.subject	Psychiatry and Mental Health
dc.subject	Cellular and Molecular Neuroscience
dc.subject	Molecular Biology
dc.title	Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
dc.type	/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version	Peer reviewed
dc.identifier.doi	10.1038/s41380-022-01710-8
dc.relation.url	http://www.scopus.com/inward/record.url?scp=85136173551&partnerID=8YFLogxK
dc.contributor.department	Faculty of Medicine