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Heterogeneity in the use of biologics for severe asthma in Europe : a SHARP ERS study

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Frix, Anne Noelle
dc.contributor.author Heaney, Liam G.
dc.contributor.author Dahlén, Barbro
dc.contributor.author Mihaltan, Florin
dc.contributor.author Sergejeva, Svetlana
dc.contributor.author Popović-Grle, Sanja
dc.contributor.author Sedlak, Vratislav
dc.contributor.author Lehtimäki, Lauri
dc.contributor.author Bourdin, Arnaud
dc.contributor.author Korn, Stephanie
dc.contributor.author Zervas, Eleftherios
dc.contributor.author Csoma, Zsuzsanna
dc.contributor.author Lúðvíksdóttir, Dóra
dc.contributor.author Butler, Marcus
dc.contributor.author Canonica, Giorgio Walter
dc.contributor.author Grisle, Ineta
dc.contributor.author Bieksiene, Kristina
dc.contributor.author Ten Brinke, Anneke
dc.contributor.author Kuna, Piotr
dc.contributor.author Loureiro, Claudia Chaves
dc.contributor.author Nenasheva, Natalia M.
dc.contributor.author Lazic, Zorica
dc.contributor.author Škrgat, Sabina
dc.contributor.author Ramos-Barbon, David
dc.contributor.author Leuppi, Joerg
dc.contributor.author Gemicioglu, Bilun
dc.contributor.author Bossios, Apostolos
dc.contributor.author Porsbjerg, Celeste M.
dc.contributor.author Bel, Elisabeth H.
dc.contributor.author Djukanovic, Ratko
dc.contributor.author Louis, Renaud
dc.date.accessioned 2023-01-11T01:04:20Z
dc.date.available 2023-01-11T01:04:20Z
dc.date.issued 2022-10-01
dc.identifier.citation Frix , A N , Heaney , L G , Dahlén , B , Mihaltan , F , Sergejeva , S , Popović-Grle , S , Sedlak , V , Lehtimäki , L , Bourdin , A , Korn , S , Zervas , E , Csoma , Z , Lúðvíksdóttir , D , Butler , M , Canonica , G W , Grisle , I , Bieksiene , K , Ten Brinke , A , Kuna , P , Loureiro , C C , Nenasheva , N M , Lazic , Z , Škrgat , S , Ramos-Barbon , D , Leuppi , J , Gemicioglu , B , Bossios , A , Porsbjerg , C M , Bel , E H , Djukanovic , R & Louis , R 2022 , ' Heterogeneity in the use of biologics for severe asthma in Europe : a SHARP ERS study ' , ERJ Open Research , vol. 8 , no. 4 , 00273-2022 . https://doi.org/10.1183/23120541.00273-2022
dc.identifier.issn 2312-0541
dc.identifier.other 71067927
dc.identifier.other 12ef58f1-c059-49b9-af7e-81f0322b8088
dc.identifier.other 85140483184
dc.identifier.uri https://hdl.handle.net/20.500.11815/3842
dc.description Funding Information: The SHARP National Leads survey revealed that corticosteroid-induced toxicity was assessed in 20 countries (mainly by clinical evaluation and cortisol blood levels). This was supported by data extracted from the Experts Broad Survey, which showed evaluation by 70% of experts. Cortisol blood level and clinical evaluation were also the most commonly used assessment modalities. Funding Information: Support statement: The SHARP CRC has been supported by financial and other contributions from the following consortium partners: European Respiratory Society, GlaxoSmithKline Research and Development Limited, Chiesi Farmaceutici SPA, Novartis Pharma AG, Sanofi-Genzyme Corporation, and Teva Branded Pharmaceutical Products R&D, Inc. Funding information for this article has been deposited with the Crossref Funder Registry. Publisher Copyright: © The authors 2022.
dc.description.abstract Introduction Treatment with biologics for severe asthma is informed by international and national guidelines and defined by national regulating bodies, but how these drugs are used in real-life is unknown. Materials and methods The European Respiratory Society (ERS) SHARP Clinical Research Collaboration conducted a three-step survey collecting information on asthma biologics use in Europe. Five geographically distant countries defined the survey questions, focusing on seven end-points: biologics availability and financial issues, prescription and administration modalities, inclusion criteria, continuation criteria, switching biologics, combining biologics and evaluation of corticosteroid toxicity. The survey was then sent to SHARP National Leads of 28 European countries. Finally, selected questions were submitted to a broad group of 263 asthma experts identified by national societies. Results Availability of biologics varied between countries, with 17 out of 28 countries having all five existing biologics. Authorised prescribers (pulmonologists and other specialists) also differed. In-hospital administration was the preferred deliverance modality. While exacerbation rate was used as an inclusion criterion in all countries, forced expiratory volume in 1 s was used in 46%. Blood eosinophils were an inclusion criterion in all countries for interleukin-5 (IL-5)-targeted and IL-4/IL-13-targeted biologics, with varying thresholds. There were no formally established criteria for continuing biologics. Reduction in exacerbations represented the most important benchmark, followed by improvement in asthma control and quality of life. Only 73% (191 out of 263) of surveyed clinicians assessed their patients for corticosteroid-induced toxicity. Conclusion Our study reveals important heterogeneity in the use of asthma biologics across Europe. To what extent this impacts on clinical outcomes relevant to patients and healthcare services needs further investigation.
dc.format.extent 733240
dc.language.iso en
dc.relation.ispartofseries ERJ Open Research; 8(4)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Lungnalæknisfræði
dc.subject Pulmonary and Respiratory Medicine
dc.title Heterogeneity in the use of biologics for severe asthma in Europe : a SHARP ERS study
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1183/23120541.00273-2022
dc.relation.url http://www.scopus.com/inward/record.url?scp=85140483184&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine

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