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HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor Reykjavik University
dc.contributor.author Olafsdottir, Thorunn A
dc.contributor.author Bjarnadottir, Kristbjorg
dc.contributor.author Norddahl, Gudmundur L.
dc.contributor.author Halldórsson, Gísli Hreinn
dc.contributor.author Melsted, Páll
dc.contributor.author Gunnarsdottir, Kristbjorg
dc.contributor.author Ivarsdottir, Erna
dc.contributor.author Olafsdottir, Thorhildur
dc.contributor.author Arnthorsson, Asgeir O
dc.contributor.author Theodors, Fannar
dc.contributor.author Eyþórsson, Elías Sæbjörn
dc.contributor.author Helgason, Dadi
dc.contributor.author Eggertsson, Hannes P.
dc.contributor.author Masson, Gisli
dc.contributor.author Bjarnadottir, Solveig
dc.contributor.author Sævarsdóttir, Sædís
dc.contributor.author Runólfsdóttir, Hrafnhildur L.
dc.contributor.author Ólafsson, Ísleifur
dc.contributor.author Saemundsdottir, Jona
dc.contributor.author Sigurðsson, Martin Ingi
dc.contributor.author Ingvarsson, Ragnar Freyr
dc.contributor.author Pálsson, Runólfur
dc.contributor.author Thorgeirsson, Gudmundur
dc.contributor.author Halldórsson, Bjarni Vilhjálmur
dc.contributor.author Holm, Hilma
dc.contributor.author Kristjánsson, Már
dc.contributor.author Sulem, Patrick
dc.contributor.author Þorsteinsdóttir, Unnur
dc.contributor.author Jónsdóttir, Ingileif
dc.contributor.author Gudbjartsson, Daniel F
dc.contributor.author Stefansson, Kari
dc.date.accessioned 2022-10-18T01:03:28Z
dc.date.available 2022-10-18T01:03:28Z
dc.date.issued 2022-09-06
dc.identifier.citation Olafsdottir , T A , Bjarnadottir , K , Norddahl , G L , Halldórsson , G H , Melsted , P , Gunnarsdottir , K , Ivarsdottir , E , Olafsdottir , T , Arnthorsson , A O , Theodors , F , Eyþórsson , E S , Helgason , D , Eggertsson , H P , Masson , G , Bjarnadottir , S , Sævarsdóttir , S , Runólfsdóttir , H L , Ólafsson , Í , Saemundsdottir , J , Sigurðsson , M I , Ingvarsson , R F , Pálsson , R , Thorgeirsson , G , Halldórsson , B V , Holm , H , Kristjánsson , M , Sulem , P , Þorsteinsdóttir , U , Jónsdóttir , I , Gudbjartsson , D F & Stefansson , K 2022 , ' HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2 ' , Communications Biology , vol. 5 , no. 1 , 914 , pp. 914 . https://doi.org/10.1038/s42003-022-03893-w
dc.identifier.issn 2399-3642
dc.identifier.other PURE: 59354025
dc.identifier.other PURE UUID: 8524246c-4139-469c-bfe2-8738490acbf5
dc.identifier.other PubMedCentral: PMC9446630
dc.identifier.other Scopus: 85137309107
dc.identifier.other unpaywall: 10.1038/s42003-022-03893-w
dc.identifier.other WOS: 000851290400007
dc.identifier.uri https://hdl.handle.net/20.500.11815/3520
dc.description Funding Information: We thank all of the participants that contributed samples for this study for their invaluable contribution to the research. We also thank our research staff at the Patient Recruitment Center for their thorough work. Publisher Copyright: © 2022, The Author(s).
dc.description.abstract Memory T-cell responses following SARS-CoV-2 infection have been extensively investigated but many studies have been small with a limited range of disease severity. Here we analyze SARS-CoV-2 reactive T-cell responses in 768 convalescent SARS-CoV-2-infected (cases) and 500 uninfected (controls) Icelanders. The T-cell responses are stable three to eight months after SARS-CoV-2 infection, irrespective of disease severity and even those with the mildest symptoms induce broad and persistent T-cell responses. Robust CD4+ T-cell responses are detected against all measured proteins (M, N, S and S1) while the N protein induces strongest CD8+ T-cell responses. CD4+ T-cell responses correlate with disease severity, humoral responses and age, whereas CD8+ T-cell responses correlate with age and functional antibodies. Further, CD8+ T-cell responses associate with several class I HLA alleles. Our results, provide new insight into HLA restriction of CD8+ T-cell immunity and other factors contributing to heterogeneity of T-cell responses following SARS-CoV-2 infection.
dc.format.extent 914
dc.language.iso en
dc.relation.ispartofseries Communications Biology; 5(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Lífefna- og sameindalíffræði
dc.subject Svæfinga- og gjörgæslulæknisfræði
dc.subject Nýrnalæknisfræði
dc.subject Smitsjúkdómalæknisfræði
dc.subject Alleles
dc.subject CD8-Positive T-Lymphocytes
dc.subject COVID-19/genetics
dc.subject Humans
dc.subject SARS-CoV-2
dc.subject Severity of Illness Index
dc.subject Agricultural and Biological Sciences (all)
dc.subject Biochemistry, Genetics and Molecular Biology (all)
dc.subject Medicine (miscellaneous)
dc.title HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 36068292
dc.identifier.doi https://doi.org/10.1038/s42003-022-03893-w
dc.relation.url http://www.scopus.com/inward/record.url?scp=85137309107&partnerID=8YFLogxK
dc.contributor.department Faculty of Industrial Engineering, Mechanical Engineering and Computer Science
dc.contributor.department Faculty of Medicine
dc.contributor.department Internal Medicine and Emergency Services
dc.contributor.department Clinical Laboratory Services, Diagnostics and Blood Bank
dc.contributor.department Perioperative Services
dc.contributor.department Other departments
dc.contributor.department Office of Division of Clinical Services I
dc.contributor.school Health Sciences

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