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Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Svanes, Cecilie
dc.contributor.author Johannessen, Ane
dc.contributor.author Bertelsen, Randi Jacobsen
dc.contributor.author Dharmage, Shyamali
dc.contributor.author Benediktsdottir, Bryndis
dc.contributor.author Bråbäck, Lennart
dc.contributor.author Gislason, Thorarinn
dc.contributor.author Holm, Mathias
dc.contributor.author Jõgi, Oskar
dc.contributor.author Lodge, Caroline J.
dc.contributor.author Malinovschi, Andrei
dc.contributor.author Martinez-Moratalla, Jesus
dc.contributor.author Oudin, Anna
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Timm, Signe
dc.contributor.author Janson, Christer
dc.contributor.author Real, Francisco Gomez
dc.contributor.author Schlünssen, Vivi
dc.date.accessioned 2022-09-23T01:01:50Z
dc.date.available 2022-09-23T01:01:50Z
dc.date.issued 2022-06-01
dc.identifier.citation Svanes , C , Johannessen , A , Bertelsen , R J , Dharmage , S , Benediktsdottir , B , Bråbäck , L , Gislason , T , Holm , M , Jõgi , O , Lodge , C J , Malinovschi , A , Martinez-Moratalla , J , Oudin , A , Sánchez-Ramos , J L , Timm , S , Janson , C , Real , F G & Schlünssen , V 2022 , ' Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort ' , BMJ Open , vol. 12 , no. 6 , e059434 , pp. e059434 . https://doi.org/10.1136/bmjopen-2021-059434
dc.identifier.issn 2044-6055
dc.identifier.other PURE: 59836539
dc.identifier.other PURE UUID: 9610e900-fc7a-4131-867b-715b5405b548
dc.identifier.other Scopus: 85131231942
dc.identifier.other unpaywall: 10.1136/bmjopen-2021-059434
dc.identifier.uri https://hdl.handle.net/20.500.11815/3477
dc.description Funding Information: Funding Coordination of the RHINESSA study has received funding from the Research Council of Norway (Grants No. 274767, 214123, 228174, 230 827 and 273838), ERC StG project BRuSH #804199, the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633 212 (the ALEC Study WP2), the Bergen Medical Research Foundation, and the Western Norwegian Regional Health Authorities (Grants No. 912011, 911 892 and 911631). Study centres have further received local funding from the following: Bergen: the above grants for study establishment and co-ordination, and, in addition, World University Network (REF and Sustainability grants), Norwegian Labour Inspection, the Norwegian Asthma and Allergy Association and Trond Mohn Foundation (Grant ID BFS2017TMT02). Albacete and Huelva: Sociedad Española de Patología Respiratoria (SEPAR) Fondo de Investigación Sanitaria (FIS PS09). Gøteborg, Umeå and Uppsala: the Swedish Heart and Lung Foundation, the Swedish Asthma and Allergy Association. Reykjavik: Iceland University. Melbourne: Australian National Health and Medical Research Council (NHMRC) Project Grant ID1128450. Tartu: the Estonian Research Council (Grant No. PUT562). Århus: The Danish Wood Foundation (Grant No. 444508795), the Danish Working Environment Authority (Grant No. 20150067134), Aarhus University (PhD scholarship).The RHINE study received funding by Norwegian Research Council, Norwegian Asthma and Allergy Association, Danish Lung Association, Swedish Heart and Lung Foundation, Vårdal Foundation for Health CareHealthcare Science and Allergy Research, Swedish Asthma and Allergy Association, Icelandic Research Council, and Estonian Science Foundation. The RHINE IV ongoing study has received funding from the Research Council of Norway project Life-GAP grant No. 300 765.Co-ordination of the ECRHS study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633 212 (the ALEC study), the Medical Research Council (ECRHS III) and the European Commission FP5 and FP7 (ECRHS I and II). The ECRHS IV ongoing study in the ten RHINESSA study centres has received funding from the European Union’s Horizon 2020 research and innovation programme projects EPHOR under grant agreement No. 874 703 and European Research Council (ERC) project BRuSH under grant agreement No. 804199, and from the Research Council of Norway grant No. 273 838. Funding agencies for ECRHS I, II and III are reported in online supplement. Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
dc.description.abstract Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014-17 in a questionnaire study (N=8818, age 18-53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20-44 years old, at 8-10 years intervals. Study protocols are harmonised across generations. Findings to date Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father's exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father's exposures to offspring health and disease through impact on offspring DNA methylation. Future plans Follow-up is planned at 5-8 years intervals, first in 2021-2023. Linkage with health registries contributes to follow-up of the cohort.
dc.format.extent e059434
dc.language.iso en
dc.relation.ispartofseries BMJ Open; 12(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Lungnalæknisfræði
dc.subject Allergy
dc.subject Asthma
dc.subject Chronic airways disease
dc.subject EPIDEMIOLOGY
dc.subject PUBLIC HEALTH
dc.subject Humans
dc.subject Middle Aged
dc.subject Hypersensitivity/complications
dc.subject Male
dc.subject Spain
dc.subject Young Adult
dc.subject Europe/epidemiology
dc.subject Adolescent
dc.subject Adult
dc.subject Asthma/epidemiology
dc.subject Cohort Studies
dc.subject Medicine (all)
dc.title Cohort profile : the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.pmid 35654464
dc.identifier.doi https://doi.org/10.1136/bmjopen-2021-059434
dc.relation.url http://www.scopus.com/inward/record.url?scp=85131231942&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine
dc.contributor.department Internal Medicine and Emergency Services


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