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Physicochemical and Stability Evaluation of Topical Niosomal Encapsulating Fosinopril/γ-Cyclodextrin Complex for Ocular Delivery

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dc.contributor Landspitali - The National University Hospital of Iceland
dc.contributor.author Hnin, Hay Marn
dc.contributor.author Stefánsson, Einar
dc.contributor.author Loftsson, Thorsteinn
dc.contributor.author Asasutjarit, Rathapon
dc.contributor.author Charnvanich, Dusadee
dc.contributor.author Jansook, Phatsawee
dc.date.accessioned 2022-09-22T01:02:02Z
dc.date.available 2022-09-22T01:02:02Z
dc.date.issued 2022-06
dc.identifier.citation Hnin , H M , Stefánsson , E , Loftsson , T , Asasutjarit , R , Charnvanich , D & Jansook , P 2022 , ' Physicochemical and Stability Evaluation of Topical Niosomal Encapsulating Fosinopril/γ-Cyclodextrin Complex for Ocular Delivery ' , Pharmaceutics , vol. 14 , no. 6 , 1147 . https://doi.org/10.3390/pharmaceutics14061147
dc.identifier.issn 1999-4923
dc.identifier.other PURE: 59760901
dc.identifier.other PURE UUID: fba4c560-c381-415d-ac0f-9d282cd0ed62
dc.identifier.other Scopus: 85131539344
dc.identifier.uri https://hdl.handle.net/20.500.11815/3475
dc.description Funding Information: Funding: This work was financially supported by the European Union’s Eurostar Program under project No. PREVIN E11008 and by The Second Century Fund (C2F), Chulalongkorn University. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstract This study aimed to develop a chemically stable niosomal eye drop containing fosinopril (FOS) for lowering intraocular pressure. The effects of cyclodextrin (CD), surfactant types and membrane stabilizer/charged inducers on physiochemical and chemical properties of niosome were evaluated. The pH value, average particle size, size distribution and zeta potentials were within the acceptable range. All niosomal formulations were shown to be slightly hypertonic with low viscosity. Span® 60/dicetyl phosphate niosomes in the presence and absence of γCD were selected as the optimum formulations according to their high %entrapment efficiency and negative zeta potential values as well as controlled release profile. According to ex vivo permeation study, the obtained lowest flux and apparent permeability coefficient values confirmed that FOS/γCD complex was encapsulated within the inner aqueous core of niosome and could be able to protect FOS from its hydrolytic degradation. The in vitro cytotoxicity revealed that niosome entrapped FOS or FOS/γCD formulations were moderate irritation to the eyes. Furthermore, FOS-loaded niosomal preparations exhibited good physical and chemical stabilities especially of those in the presence of γCD, for at least three months under the storage condition of 2–8 °C.
dc.format.extent
dc.language.iso en
dc.relation.ispartofseries Pharmaceutics; 14(6)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Augnlæknisfræði
dc.subject cyclodextrin
dc.subject encapsulation
dc.subject fosinopril sodium
dc.subject niosomes
dc.subject ophthalmic
dc.subject stabilization
dc.subject Pharmaceutical Science
dc.title Physicochemical and Stability Evaluation of Topical Niosomal Encapsulating Fosinopril/γ-Cyclodextrin Complex for Ocular Delivery
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.3390/pharmaceutics14061147
dc.relation.url http://www.scopus.com/inward/record.url?scp=85131539344&partnerID=8YFLogxK
dc.contributor.department Other departments
dc.contributor.department Faculty of Medicine


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