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Genotoxicity assessment of chemical mixtures

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dc.contributor.author EFSA Scientific Committee
dc.date.accessioned 2022-09-10T01:02:19Z
dc.date.available 2022-09-10T01:02:19Z
dc.date.issued 2019
dc.identifier.citation EFSA Scientific Committee 2019 , ' Genotoxicity assessment of chemical mixtures ' , EFSA Journal , vol. 17 , no. 1 , 5519 , pp. 1-11 . https://doi.org/10.2903/j.efsa.2019.5519
dc.identifier.issn 1831-4732
dc.identifier.other PURE: 42584352
dc.identifier.other PURE UUID: ee83c9a1-93f7-4462-86e4-df84b440a186
dc.identifier.other Scopus: 85102749771
dc.identifier.uri https://hdl.handle.net/20.500.11815/3451
dc.description Publisher Copyright: © 2019 European Food Safety Authority.
dc.description.abstract The EFSA Scientific Committee addressed in this document the peculiarities related to the genotoxicity assessment of chemical mixtures. The EFSA Scientific Committee suggests that first a mixture should be chemically characterised as far as possible. Although the characterisation of mixtures is relevant also for other toxicity aspects, it is particularly significant for the assessment of genotoxicity. If a mixture contains one or more chemical substances that are individually assessed to be genotoxic in vivo via a relevant route of administration, the mixture raises concern for genotoxicity. If a fully chemically defined mixture does not contain genotoxic chemical substances, the mixture is of no concern with respect to genotoxicity. If a mixture contains a fraction of chemical substances that have not been chemically identified, experimental testing of the unidentified fraction should be considered as the first option or, if this is not feasible, testing of the whole mixture should be undertaken. If testing of these fraction(s) or of the whole mixture in an adequately performed set of in vitro assays provides clearly negative results, the mixture does not raise concern for genotoxicity. If in vitro testing provides one or more positive results, an in vivo follow-up study should be considered. For negative results in the in vivo follow-up test(s), the possible limitations of in vivo testing should be weighed in an uncertainty analysis before reaching a conclusion of no concern with respect to genotoxicity. For positive results in the in vivo follow-up test(s), it can be concluded that the mixture does raise a concern about genotoxicity.
dc.format.extent 11
dc.format.extent 1-11
dc.language.iso en
dc.relation.ispartofseries EFSA Journal; 17(1)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Chemical mixtures
dc.subject Genotoxicity assessment
dc.subject Uncertainty analysis
dc.subject Parasitology
dc.subject Food Science
dc.subject Microbiology
dc.subject Animal Science and Zoology
dc.subject Veterinary (miscellaneous)
dc.subject Plant Science
dc.title Genotoxicity assessment of chemical mixtures
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.2903/j.efsa.2019.5519
dc.relation.url http://www.scopus.com/inward/record.url?scp=85102749771&partnerID=8YFLogxK
dc.contributor.department Faculty of Food Science and Nutrition


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