Title: | RETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI |
Author: |
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Date: | 2020-11-01 |
Language: | English |
Scope: | 9 |
University/Institute: | Landspitali - The National University Hospital of Iceland |
Department: | Faculty of Medicine Other departments |
Series: | Retina (Philadelphia, Pa.); 40(11) |
ISSN: | 0275-004X |
DOI: | 10.1097/IAE.0000000000002719 |
Subject: | Ophthalmology |
URI: | https://hdl.handle.net/20.500.11815/3427 |
Citation:Brouwer , N J , Marinkovic , M , Bleeker , J C , El Filali , M , Stefansson , E , Luyten , G P M & Jager , M J 2020 , ' RETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI ' , Retina (Philadelphia, Pa.) , vol. 40 , no. 11 , pp. 2207-2215 . https://doi.org/10.1097/IAE.0000000000002719
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Abstract:PURPOSE: To compare retinal vessel oxygenation in eyes with an untreated choroidal nevus or choroidal melanoma. METHODS: The affected and fellow eye of patients with an untreated choroidal nevus (n = 42) or choroidal melanoma (n = 45) were investigated using noninvasive retinal oximetry (Oxymap T1). Oxygen saturation of arterioles (ArtSat) and venules (VenSat) was determined, together with the arteriovenous difference (AV-difference). RESULTS: In choroidal nevus patients, retinal oximetry did not differ between the affected and fellow eye: the mean ArtSat was 94.5% and 94.2% (P = 0.56), the VenSat was 60.5% and 61.3% (P = 0.35), and the AV-difference was 34.0% and 32.9% (P = 0.18), respectively. In choroidal melanoma patients, alterations were detected: the mean ArtSat was 94.8% and 93.2% (P = 0.006), the VenSat was 58.0% and 60.0% (P = 0.014), and the AV-difference was 36.8% and 33.2% (P < 0.001), respectively. The largest increase in AV-difference was observed between the retinal halves without the lesion in melanoma eyes compared with the corresponding half in the fellow eye (37.5% vs. 32.1%, P < 0.001). CONCLUSION: Although retinal oximetry was not significantly altered in eyes with a choroidal nevus, eyes with choroidal melanoma showed an increased ArtSat and decreased VenSat, leading to an increased AV-difference. These changes may be caused by inflammation and a higher metabolism, with larger oxygen consumption, leading to altered blood flow and intraocular oxygen relocation.
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Description:Acknowledgments The authors thank Katinka Emmanouilidis-van der Spek and Wouter B.H.J. Vehmeijer (Leiden University Medical Center, the Netherlands) for their support with data acquisition and software analysis.
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